The development of the fetal vermis: an <i>in‐utero</i> sonographic evaluation

Zalel, Yaron; Ds, Seidman; Brand, Nathan; Lipitz, Shlomo; Achiron, Reuven

doi:10.1046/j.0960-7692.2001.00621.x

Cited by 76 publications

(18 citation statements)

References 17 publications

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“…In an earlier study, the primary fissure was visible on transvaginal sonography not before 27 to 30 weeks 11 . The striking difference between published prenatal nomograms of vermian length attests to the difficulty in correctly identifying and measuring it 10 – 12 . We concur with Viñals et al 10 that volume contrast imaging facilitates acquisition and provides clear images of the vermis that allow for unambiguous distinction from the cerebellar hemispheres.…”

Section: Discussionsupporting

confidence: 82%

Sonographic Examination of the Fetal Vermis

Shen

Valsky

Rabinowitz

et al. 2011

Journal of Ultrasound in Medicine

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Prenatal imaging of the fetal cerebellar vermis is challenging even for experienced examiners. We found that by aiming the ultrasound beam through the mastoid fontanel and then rotating the data set in a multiplanar reconstruction and applying volume contrast imaging in the C plane, we were consistently able to obtain images of the vermis in the standard midsagittal plane. Images of the fetal vermis suitable for morphologic evaluation were obtained in 408 of 414 cases (98.5%) at gestational ages of 18 weeks to 31 weeks 6 days; the examination time was only minimally increased.

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Section: Discussionsupporting

confidence: 82%

Sonographic Examination of the Fetal Vermis

Shen

Valsky

Rabinowitz

et al. 2011

Journal of Ultrasound in Medicine

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“…The vermis height was defined as the maximum distance between the most cranial portion of the culmen and the most caudal portion of the uvula. [ 22 – 24 ] ( Fig 1 ).…”

Section: Methodsmentioning

confidence: 99%

Reference Charts for Fetal Cerebellar Vermis Height: A Prospective Cross-Sectional Study of 10605 Fetuses

Cignini¹,

Giorlandino²,

Brutti

et al. 2016

PLoS ONE

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ObjectiveTo establish reference charts for fetal cerebellar vermis height in an unselected population.MethodsA prospective cross-sectional study between September 2009 and December 2014 was carried out at ALTAMEDICA Fetal–Maternal Medical Centre, Rome, Italy. Of 25203 fetal biometric measurements, 12167 (48%) measurements of the cerebellar vermis were available. After excluding 1562 (12.8%) measurements, a total of 10605 (87.2%) fetuses were considered and analyzed once only. Parametric and nonparametric quantile regression models were used for the statistical analysis. In order to evaluate the robustness of the proposed reference charts regarding various distributional assumptions on the ultrasound measurements at hand, we compared the gestational age-specific reference curves we produced through the statistical methods used. Normal mean height based on parametric and nonparametric methods were defined for each week of gestation and the regression equation expressing the height of the cerebellar vermis as a function of gestational age was calculated. Finally the correlation between dimension/gestation was measured.ResultsThe mean height of the cerebellar vermis was 12.7mm (SD, 1.6mm; 95% confidence interval, 12.7–12.8mm). The regression equation expressing the height of the CV as a function of the gestational age was: height (mm) = -4.85+0.78 x gestational age. The correlation between dimension/gestation was expressed by the coefficient r = 0.87.ConclusionThis is the first prospective cross-sectional study on fetal cerebellar vermis biometry with such a large sample size reported in literature. It is a detailed statistical survey and contains new centile-based reference charts for fetal height of cerebellar vermis measurements.

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“…14,[35][36][37][38][39][40][41][42] Premature births can interrupt cerebellum growth. Investigation of whether the adverse effect or prematurity on cerebellar dimensions persists after birth has shown smaller cerebellar dimensions in children born prematurely compared to those born at term.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Cerebellar Dimensions Using Magnetic Resonance Imaging in Children Aged 0-4 Years

Ayhan¹,

Yeğinoğlu²,

Kul³

2015

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Several diseases progress with cerebellar atrophy and hypoplasia. Cerebellum dimension measurements facilitating the assessment of decreases in cerebellum size on radiological images between the ages of 0 and 4 years in particular, when the cerebellum is still growing, will be of considerable use in clinical practice and appropriate for measurement value standardization. This will allow easier interpretetation of findings, together with more accurate diagnosis or a decrease in delays caused by false diagnosis. This study, the purpose of which was to obtain a database suitable for clinical use by performing cerebellar development dimension measurements in normal individuals aged 0-4 years, investigated the effect on cerebellar dimensions of parameters such as height, weight, head circumference and birth week. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : One hundred fourty children aged 0-4 years, 56 girls and 84 boys, undergoing magnetic resonance imaging of the brain at the Karadeniz Technical University Farabi Hospital Radiology Department with no structural cerebral or cerebellar abnormalities were included in the study. R Re es su ul lt ts s: : In this study of cerebellar dimensions in healthy children, these were positively correlated with weight, head circumference and height in both genders. Preterm birth had a significant effect on cerebellar dimensions. C Co on nc cl lu us si io on n: : In conclusion, this scale developed by measuring the cerebellar dimensions of healthy children aged 0-4 years will be of considerable practical assistance in terms of assessing measurements performed in a clinical environment. K Ke ey y W Wo or rd ds s: : Magnetic resonance imaging; child Ö ÖZ ZE ET T A Am ma aç ç: : Serebellumun atrofisi ve hipoplazisi ile giden birçok hastalık mevcuttur. Özellikle serebellumun büyümeye devam ettiği 0-4 yaş arasında radyolojik görüntülerde serebellum boyutlarındaki azalmanın değerlendirilebilmesi için serebellum boyutlarının ölçümleri, klinikte pratik olarak yararlı olacak ve ölçüm değerlerinin standardizasyonu için uygun olacaktır. Böylece bulguların daha kolay tanımlanabileceği ve doğru tanı konulamaması ya da tanı konulmasındaki gecikmelerin azalacağı öngörülmektedir. Bu nedenle 0-4 yaş arası normal bireylerde serebellum gelişimi boyut ölçümleri ile yaparak klinik kullanıma uygun bir veri dökümü elde etmeyi amaçladığımız bu çalışmada boy, kilo, baş çevresi, doğum haftası gibi parametrelerin serebellum boyutları üzerine etkilerini de değerlendirdik. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Araştırmaya Karadeniz Teknik Üniversitesi Radyoloji Bölümünde beyin manyetik rezonans görüntülemesi yapılan ve serebral ve serebellum anomalisi olmayan 0-4 yaş arasındaki 56 kız, 84 erkek çocuk dahil edilmiştir. B Bu ul lg gu ul la ar r: : Sağlıklı ço-cuklarda serebellum boyutlarını saptadığımız bu çalışmada, serebellum boyutlarının her iki cinsiyette boy, kilo ve baş çevresi ile pozitif korelasyon olduğu ve erken do...

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The development of the fetal vermis: an in‐utero sonographic evaluation

Abstract: The present data offer the normal range of the vermian measurements throughout gestation. These values may allow intrauterine assessment of the development of the cerebellar vermis, as well as the posterior fossa.

Cited by 76 publications

References 17 publications

Sonographic Examination of the Fetal Vermis

Sonographic Examination of the Fetal Vermis

Reference Charts for Fetal Cerebellar Vermis Height: A Prospective Cross-Sectional Study of 10605 Fetuses

Assessment of Cerebellar Dimensions Using Magnetic Resonance Imaging in Children Aged 0-4 Years

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