The development of the EORTC QLQ-C15-PAL: A shortened questionnaire for cancer patients in palliative care

Grøenvold, Mogens; Petersen, Morten Aa.; Aaronson, Neil K.; Arrarás, Juan Ignacio; Blazeby, Jane M; Bottomley, Andrew; Fayers, Peter; Graeff, Alexander de; Hammerlid, Eva; Kaasa, Stein; Sprangers, Mirjam A. G.; Bjørner, Jakob Bue

doi:10.1016/j.ejca.2005.06.022

Cited by 517 publications

(458 citation statements)

References 27 publications

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“…EORTC-QLQ-C30 is extensively validated for patients with cancer [36–38] and the use of it is supported by standardized procedures for scores [39] and evidence for interpretation of scores [39,40]. EORTC-QLQ-C15-PAL[29] has become a shortened version of EORTC-QLQ-C30 through IRT preserving item-properties and procedures for scores [35,41–43]. …”

Section: Methodsmentioning

confidence: 99%

Is the high intensity symptoms experienced by patients admitted with chronic obstructive pulmonary disease documented by health professionals? - a prospective survey with comparison of patient reported outcomes and medical records

Bech

Bové

Marsaa

et al. 2018

European Clinical Respiratory Journal

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Context: Patients with chronic obstructive pulmonary disease (COPD) have a high symptom burden and reduced quality of life. There is an increasing attention on palliation for patients with COPD. Recognition of symptoms is a prerequisite for palliation. Objectives: We aim to investigate the extent to which symptoms in patients with COPD are recognized in the documentation of the health professionals, indicated in ‘Doctors Symptom Recognition Rate’ (DSR), ‘Nurses Symptom Recognition Rate’ (NSR) or ‘Doctors and/or Nurses Symptom Recognition rates ’(DNSR) as a team, respectively. Methods: Patients with COPD (n = 40) admitted in two respiratory units, responded within 48 h on two symptom-screening-tools that access quality of life; COPD assessment test (CAT) used for the treatment of COPD and EORTC-QLQ-C15-PAL used for palliation in patients with cancer. Patient-described symptomatology was compared to the symptoms as recognized in the documentation of doctors and/or nurses. Results: There was a significant discrepancy between the symptomatology indicated by patients with COPD on CAT and EORTC-QLQ-C15-PAL, and the degree by which it was recognized in the medical records indicated in DSR or NSR. In 30 out of 44 items DSR or NSR were < 70%. There was a significant difference between DNSR versus DSR or NSR, respectively, in 19 out of 22 items. Conclusion: A team-based symptom recognition DNSR is superior when compared to DSR or NSR.Team-based systematic screening is suggested as a pathway to increase symptom recognition in patients with COPD. Increased rates of symptom recognition may improve symptom alleviation and thus palliation.

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Section: Methodsmentioning

confidence: 99%

Is the high intensity symptoms experienced by patients admitted with chronic obstructive pulmonary disease documented by health professionals? - a prospective survey with comparison of patient reported outcomes and medical records

Bech

Bové

Marsaa

et al. 2018

European Clinical Respiratory Journal

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“…Table 2 includes the items from the Patient‐Generated Subjective Global Assessment (PG‐SGA)14 and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC‐QLQ) C15 PAL15 that were used to collect data pertaining to the cachexia domains for nutrition and functional and psychosocial effects. Both instruments are commonly used and well validated patient reported outcome measurements.…”

Section: Methodsmentioning

confidence: 99%

The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis

Vagnildhaug

Blum

Wilcock

et al. 2017

J cachexia sarcopenia muscle

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BackgroundA body mass index (BMI) adjusted weight loss grading system (WLGS) is related to survival in patients with cancer. The aim of this study was to examine the applicability of the WLGS by confirming its prognostic validity, evaluating its relationship to cachexia domains, and exploring its ability to predict cachexia progression.MethodsAn international, prospective observational study of patients with incurable cancer was conducted. For each patient, weight loss grade was scored 0–4. Weight loss grade 0 represents a high BMI with limited weight loss, progressing through to weight loss grade 4 representing low BMI and a high degree of weight loss. Survival analyses were used to confirm prognostic validity. Analyses of variance were used to evaluate the relationship between the WLGS and cachexia domains [anorexia, dietary intake, Karnofsky performance status (KPS), and physical and emotional functioning]. Cox regression was used to evaluate if the addition of cachexia domains to the WLGS improved prognostic accuracy. Predictive ability of cachexia progression was assessed by estimating proportion of patients progressing to a more advanced weight loss grade.ResultsOne thousand four hundred six patients were analysed (median age 66 years; 50% female, 63% KPS ≤ 70). The overall effect of the WLGS on survival was significant as expressed by change in −2 log likelihood (P < 0.001) and persisted after adjustment for age, sex, and cancer type and stage (P < 0.001). Median survival decreased across the weight loss grades ranging from 407 days (95% CI 312–502)—weight loss grade 0 to 119 days (95% CI 93–145)—weight loss grade 4. All cachexia domains significantly deteriorated with increasing weight loss grade, and deterioration was greatest for dietary intake, with a difference corresponding to 0.87 standard deviations between weight loss grades 0 and 4. The addition of KPS, anorexia, and physical and emotional functioning improved the prognostic accuracy of the WLGS. Likelihood of cachexia progression was greater in patients with weight loss grade 2 (39%) than that with weight loss grade 0 (19%) or 1 (22%).ConclusionsThe WLGS is related to survival, cachexia domains, and the likelihood of progression. Adding certain cachexia domains to the WLGS improves prognostic accuracy.

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“…The FACIT-Pal is similar to the EORTC QLQ-C15-PAL (18) and the McGill Quality of Life Questionnaire (19) in that they all have items that measure one's physical symptoms, functional status, and emotional status. However, the latter two tools are shorter than the FACIT-Pal and do not contain items that specifically assess one's relationships with family and friends (though the McGill Quality of Life Questionnaire does ask about the degree to which one feels supported).…”

Section: Introductionmentioning

confidence: 99%

Reliability and Validity of the Functional Assessment of Chronic Illness Therapy-Palliative Care (FACIT-Pal) Scale

Lyons

Bakitas

Hegel

et al. 2009

Journal of Pain and Symptom Management

156

128

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The Functional Assessment of Chronic Illness Therapy (FACIT) system provides a general, multidimensional measure of health-related quality of life (FACT-G) that can be augmented with disease or symptom-specific subscales. The 19-item palliative care subscale of the FACIT system has undergone little psychometric evaluation to date. The aim of this paper is to report the internal consistency, factor structure, and construct validity of the instrument using the palliative care subscale (FACIT-Pal). Two hundred fifty-six persons with advanced cancer in a randomized trial testing a palliative care psychoeducational intervention completed the 46-item FACIT-Pal at baseline. Internal consistency was greater than 0.74 for all subscales and the total score. Seventeen of the 19 palliative care subscale items loaded onto the four factor solution of the established core measure (FACT-G). As hypothesized, total scores were correlated with measures of symptom intensity (r = −0.73, P < 0.001) and depression (r = −0.75, P < 0.001). The FACIT-Pal was able to discriminate between participants who died within three months of completing the baseline and participants who lived for at least one year after completing the baseline assessment (t = −4.05, P <0.001). The functional well-being subscale discriminated between participants who had a Karnofsky performance score (KPS) of 70 and below and participants with a KPS score of 80 and above (t = 3.40, P <0.001). The findings support the internal consistency reliability and validity of the FACITPal as a measure of health-related quality of life for persons with advanced cancer.

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The development of the EORTC QLQ-C15-PAL: A shortened questionnaire for cancer patients in palliative care

Cited by 517 publications

References 27 publications

Is the high intensity symptoms experienced by patients admitted with chronic obstructive pulmonary disease documented by health professionals? - a prospective survey with comparison of patient reported outcomes and medical records

Is the high intensity symptoms experienced by patients admitted with chronic obstructive pulmonary disease documented by health professionals? - a prospective survey with comparison of patient reported outcomes and medical records

The applicability of a weight loss grading system in cancer cachexia: a longitudinal analysis

Reliability and Validity of the Functional Assessment of Chronic Illness Therapy-Palliative Care (FACIT-Pal) Scale

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