The development of the chromaffin cell lineage from the neural crest

Huber, Katrin; Kalcheim, Chaya; Unsicker, Klaus

doi:10.1016/j.autneu.2009.07.020

Cited by 96 publications

(78 citation statements)

References 63 publications

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“…Adrenomedullary chromaffin cells belong to the sympathoadrenal lineage of neural crest derivatives, which also gives rise to sympathetic neurons (Huber et al, 2009). It is still unclear if these two cell types derive from two distinct precursors originating from the neural crest but specified early on in their migration, or from one common bipotential progenitor.…”

Section: Chromaffin Progenitor Cellsmentioning

confidence: 99%

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Steenblock

Celis

Androutsellis-Theotokis

et al. 2017

Molecular and Cellular Endocrinology

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Section: Chromaffin Progenitor Cellsmentioning

confidence: 99%

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Steenblock

Celis

Androutsellis-Theotokis

et al. 2017

Molecular and Cellular Endocrinology

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“…Gata3 controls the initial expression of the noradrenergic marker gene TH but also generic neuronal differentiation and survival (Lim et al, 2000;Tsarovina et al, 2004;Moriguchi et al, 2006). Chromaffin cell development depends in a similar but not identical manner on the same transcriptional regulators identified in sympathetic ganglia (Huber et al, 2009). The continued Gata3 expression in the sympathoadrenal system throughout the lifetime of the animal, together with the essential role of Gata3 in the maintenance of the differentiated state in other lineages (Kouros-Mehr et al, 2006), raises the question as to the role of Gata3 in mature sympathetic neurons and chromaffin cells.…”

Section: Introductionmentioning

confidence: 99%

The Gata3 Transcription Factor Is Required for the Survival of Embryonic and Adult Sympathetic Neurons

Tsarovina¹,

Reiff²,

Stubbusch³

et al. 2010

J. Neurosci.

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The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to the adult stage, we addressed its function in differentiated sympathoadrenal cells at embryonic and adult stages by conditional Gata3 elimination. Inactivation of Gata3 in embryonic DBH-expressing neurons elicits a strong reduction in neuron numbers due to apoptotic cell death and reduced proliferation. No selective effect on noradrenergic gene expression (TH and DBH) was observed. Interestingly, Gata3 elimination in DBH-expressing neurons of adult animals also results in a virtually complete loss of sympathetic neurons. In the Gata3-deficient population, the expression of anti-apoptotic genes (Bcl-2, Bcl-x L , and NFB) is diminished, whereas the expression of pro-apoptotic genes (Bik, Bok, and Bmf) was increased. The expression of noradrenergic genes (TH and DBH) is not affected. These results demonstrate that Gata3 is continuously required for maintaining survival but not differentiation in the sympathetic neuron lineage up to mature neurons of adult animals.

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“…The cells of the sympathoadrenal lineage subsequently give rise to three major adrenergic cell types: sympathetic neurons, adrenal chromaffin cells, and small intensely fluorescent (SIF) cells (Unsicker et al 2005). Recent data from the Unsicker group who conducted single-cell electroporations with GFP-DNA into delaminating neural crest cells in chick embryos indicate that a common progenitor exists for both lineages, chromaffin cells of the adrenal medulla and sympathetic ganglia (Huber et al 2009). The developmental fate of neural crest cells is shaped by the interaction of signals within the microenvironments encountered during and after their migration and upon reaching their final destination (Dupin et al 2007;Anderson 1997).…”

Section: Introductionmentioning

confidence: 94%

Chromaffin Progenitor Cells from the Adrenal Medulla

et al. 2010

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Chromaffin cells of the adrenal medulla are neural crest-derived cells of the sympathoadrenal lineage. Different lines of evidence suggest the existence of a subpopulation of proliferation-competent progenitor cells even in the adult state. The identification of sympathoadrenal progenitors in the adrenal would greatly enhance the understanding of adrenal physiology and their potential role in adrenal pathogenesis. Isolation and differentiation of these progenitor cells in culture would provide a tool to understand their development in vitro. Furthermore, due to the close relation to sympathetic neurons, these cells might provide an expandable source of cells for cell therapy in the treatment of neurodegenerative diseases. We therefore aim to establish protocols for the efficient isolation, enrichment and differentiation of chromaffin progenitor cells to dopaminergic neurons in culture.

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The development of the chromaffin cell lineage from the neural crest

Cited by 96 publications

References 63 publications

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?

The Gata3 Transcription Factor Is Required for the Survival of Embryonic and Adult Sympathetic Neurons

Chromaffin Progenitor Cells from the Adrenal Medulla

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