The Development of Resistance to Spiramycin, Streptomycin and Chlortetracycline by Mycoplasma gallisepticum in Chick Embryos

Kiser, J. S.; Popken, F.; CLEMENTEb, J.

doi:10.2307/1587637

Cited by 4 publications

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“…Antibiotic resistance to streptomycin was shown to be induced earlier than any other antibiotic resistance and the present results confirmed previous data obtained in vitro and in ovo with Mg (Domermuth, 1960;Kiser et al, 1961) and with other human mycoplasmas of genital origin (Blith, 1958). Such a phenomenon had been attributed to a one-step mutation event, which confers highlevel resistance and is characteristic of many bac- teria.…”

Section: Discussionsupporting

confidence: 92%

“…Mataney (1957, Osborn & Pomeroy (1958), Osborn et al (1960) and Newnham and Chu (1965) observed that different strains of mycoplasmas showed considerable variations in sensitivity to a given antibiotic, probably due to extended or improperly administered therapy. Domermuth (1958Domermuth ( , 1960, Osborn et al (1960), Kiser et al (1961) and Zanella (1966) used a number of antibiotics to study, both in vivo and in vitro, how antibiotic resistance was induced in Mycoplasma gallisepticum (Mg). More recently, in vivo and in vitro tests to assess the sensitivity to a wide spectrum of chemotherapeutic agents, particularly tylosin and quinolones, have been carried out on various isolates of Mg (Kleven & Anderson, 1971;Levisohn, 1981;Lin, 1987;Kempf et al, 1989;Jordan et al, 1989;Bradbury et al, 1994;Jordan & Horrocks, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Development of antibiotic resistance inMycoplasma gallisepticum in vitro

Zanella

Martino²,

Pratelli

et al. 1998

Avian Pathology

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The results of in vitro tests for induction of antibiotic resistance in some strains of Mycoplasma gallisepticum are reported. The number of passages required to induce resistance varied considerably between different antibiotics. In two groups of tests, with different strains of M. gallisepticum, resistance ( 1 mg/ml) to streptomycin appeared after two to three passages, to erythromycin and spiramycin after five to eight passages, to tylosin after nine to eleven and to enrofloxacin after eight to ten passages. With chlortetracycline the increase in resistance was very low (no more than ten times the starting minimal inhibitory concentration). Cross-sensitivity tests using strains with induced resistance to the different antibiotics demonstrated that those which were resistant to tylosin were also resistant to other macrolides ( > 1 mg/ml), whereas strains made resistant to erythromycin and spiramycin appeared only less sensitive (2 to 200 μg/ml) to tylosin in comparison with the original strains. Streptomycin, chlortetracycline and enrofloxacin induced very little or no cross-resistance.

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Section: Discussionsupporting

confidence: 92%