The development of lighting countermeasures for sleep disruption and circadian misalignment during spaceflight

Brainard, George C.; Soler, Robert; Hanifin, John P.

doi:10.1097/mcp.0000000000000329

Cited by 44 publications

(43 citation statements)

References 52 publications

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“…Light therapy has been evaluated in healthy individuals undergoing shift work, jet travel, and space flights [8,9]. Although lighting based on light-emitting diodes has the potential to improve human health [114], its clinical application for specific human diseases still has a long way to go.…”

Section: Light and Circadian Signaling-related Therapy In Human Diseasesmentioning

confidence: 99%

“…Light pollution disrupts circadian rhythms by altering downstream signaling pathways and can lead to the development of a variety of chronic diseases, such as cancer, cardiovascular disease, diabetes, metabolic syndrome, and obesity [4][5][6][7]. Conversely, the use of light therapy has been evaluated in jet lag, shift work, and circadian rhythm disorders [8,9]. Further, melatonin treatment confers a number of beneficial effects to human health, including those related to cardiovascular function, blood pressure, the nervous system, and lipid and glucose metabolism [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu

Tain

2020

IJMS

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Light is a crucial environmental signal that affects elements of human health, including the entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase the risk of offspring developing a wide range of chronic diseases in later life. Circadian rhythm disruption in pregnant women may have deleterious consequences for their progeny. In the modern world, maternal chronodisruption can be caused by shift work, jet travel across time zones, mistimed eating, and excessive artificial light exposure at night. However, the impact of maternal chronodisruption on the developmental programming of various chronic diseases remains largely unknown. In this review, we outline the impact of light, the circadian clock, and circadian signaling pathways in pregnancy and fetal development. Additionally, we show how to induce maternal chronodisruption in animal models, examine emerging research demonstrating long-term negative implications for offspring health following maternal chronodisruption, and summarize current evidence related to light and circadian signaling pathway targeted therapies in pregnancy to prevent the development of chronic diseases in offspring.

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Section: Light and Circadian Signaling-related Therapy In Human Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu

Tain

2020

IJMS

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“…As an effective stimulus to regulate human circadian rhythm, neuroendocrine and neurobehavioral response, light could be used to treat sleep disorders and maintain health of individuals in intercontinental flight, shift work and spaceflight [ 79 , 80 ].…”

Section: Introductionmentioning

confidence: 99%

On-orbit sleep problems of astronauts and countermeasures

Wang

et al. 2018

Military Med Res

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Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very common among astronauts and has potential detrimental influences on the health of crewmembers and the safety of flight missions. Sleep in space is becoming a new medical research frontier. In this review we summarized on-orbit sleep problems of astronauts and six kinds of causes, and we presented the effects of lack of sleep on performance as well as mental and physical health, then we proposed seven kinds of countermeasures for sleep disturbance in spaceflight, including pharmacologic interventions, light treatment, crew selection and training, Traditional Chinese Medicine and so on. Furthermore, we discussed and oriented the prospect of researches on sleep in space.

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“…There is clear evidence that changed light patterns (including those during space missions) also impact on mood and sleep 14 – 16 . Certain persons are vulnerable to the decreasing amount of daylight that occurs during fall and winter and as a consequence, develop a recurrent disorder of mood and behaviour consistent with clinical depression 17 .…”

Section: Introductionmentioning

confidence: 99%

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

Kawasaki

Wisniewski

Healey³

et al. 2018

Sci Rep

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Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI) in a total of 25 healthy crew members (mean age: 34 ± 11y; 7f). The pupil responses to different light stimuli were used to assess retinal sensitivity changes. Rest-activity cycles were continuously monitored by activity watches. Overall, our data showed increased pupil responses under scotopic (mainly rod-dependent), photopic (mainly L-/M-cone dependent) as well as bright-blue light (mainly melanopsin-dependent) conditions during the time without direct sunlight. Circadian rhythm analysis revealed a significant decay of intra-daily stability, indicating more fragmented rest-activity rhythms during the dark period. Sleep and wake times (as assessed from rest-activity recordings) were significantly delayed after the first month without sunlight (p < 0.05). Our results suggest that during long-term daylight deprivation, retinal sensitivity to blue light increases, whereas circadian rhythm stability decreases and sleep-wake timing is delayed.

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The development of lighting countermeasures for sleep disruption and circadian misalignment during spaceflight

Abstract: If the new ISS lighting system is capable of improving circadian entrainment and sleep during spaceflight, it should enhance astronaut health, performance, well-being, and safety. Such an advance would open the door to future lighting applications for humans living on Earth.

Cited by 44 publications

References 52 publications

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

On-orbit sleep problems of astronauts and countermeasures

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

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