The development of diffuse panbronchiolitis during the treatment with long-term, low-dose clarithromycin for chronic sinusitis

Ando, Masayuki; Ono, Tomoko; Usagawa, Yuko; Yoshikawa, Hiroki; Hirano, Takashi; Tokimatsu, Issei; Kadota, Jun‐ichi

doi:10.1016/j.jiac.2018.07.011

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Therapeutic effects were classified into three types: markedly effective for significant improvement of clinical symptoms, effective for improved clinical symptoms, and ineffective for no improvement and even aggravation of clinical symptoms [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

Liu

2022

Journal of Healthcare Engineering

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In this research study, we will study the clinical effect of Biyuan Tongqiao granules with saline nasal irrigation for treatment of chronic sinusitis. It will also study its impacts on the computed tomography (CT) score of the nasal sinus and negative reactions in patients. For this purpose, ninety (90) patients with chronic sinusitis were admitted to the hospital (June 2019 to June 2020). They were selected as the research subjects and divided into experimental and control groups randomly with 45 cases in each group. Control group patients were treated with nasal irrigation with normal saline. While, Biyuan Tongqiao granules combined with nasal irrigation with normal saline was treated by the experimental group. The CT scores of nasal sinus, clinical effect, the incidence of adverse reactions, recurrence rate, duration of nasal mucosal epithelialization, and nasal ciliary transmission speed of both the groups were compared. The patients’ pain was assessed by the visual analogue scale (VAS), and the symptoms of sinusitis were scored by the SNOT-20 scale. The experimental group showed significantly lower sinus CT scores and better clinical effects. Adverse reactions were not observed in both the groups’ probability ( P > 0.05 ). The experimental group presented a significantly lower recurrence rate, shorter duration of nasal mucosal epithelialization, faster nasal ciliary transmission, and sharply lowers VAS scores and SNOT-20 scores than in the control group ( P < 0.05 ). This proves Biyuan Tongqiao granules and nasal irrigation with normal saline can effectually boost the clinical efficacy and lessen the computed tomography score of nasal sinus in chronic sinusitis patients. It has a worthy clinical application and promotion.

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Section: Methodsmentioning

confidence: 99%

Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

Liu

2022

Journal of Healthcare Engineering

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“…Macrolide antibiotics can interfere with bacterial protein synthesis even if they are below minimal inhibitory concentration (MIC), and they also have such antimicrobial activity to Pseudomonas aeruginosa (PA), which is resistant to macrolides, 27 indicating that the antimicrobial effect is not dependent on its direct antibacterial activity but is related to its immunomodulatory effect. 28 , 29 The immunomodulatory mechanisms of macrolides include inhibition of pathogenic microorganisms from adhering to epithelial cells, blocking of toxic factors to reduce bacterial virulence, and inhibition of microbial biofilm formation in chronic airway infection. The inhibition of PA biofilm formation is of particular concern; 30 the mechanism may be that macrolide antibiotics inhibit the expression of flagellin to weaken the motility of pseudomonas and inhibit the production of alginate, which is an important component in biofilm formation, thereby inhibiting PA from damaging epithelial cells or stimulating cytotoxicity of neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases

Sun

2021

Pediatr Res

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Macrolide antibiotics are one of the most commonly used broad-spectrum antibiotics. They have an inhibitory effect on a variety of respiratory pathogens; besides, they have non-anti-infective effects, including anti-inflammatory, regulating airway secretion, immune regulation, and other effects. A growing number of studies have shown that the non-anti-infective effects of macrolides have important and potential value in the treatment of pediatric chronic airway diseases; the therapy was described as “long-term, low-dose usage”; unfortunately, there is no guideline or consensus that applies to children. To better carry out the mechanism and clinical research of non-anti-infective effect and promote its rational use in children, the authors summarize the evidence of the usage of long-term, low-dose macrolide antibiotic therapy (LLMAT) in the treatment of chronic airway diseases in children and the progress in recent years. Impact This review summarizes the evidence (mostly in recent 5 years) of the usage of long-term, low-dose macrolide antibiotic therapy in the treatment of chronic airway diseases. The recent studies and guidelines support and enrich the point that long-term, low-dose macrolide antibiotic therapy has potential benefit for children with severe asthma, CF, non-CF bronchiectasis, and BO, which provides clinical references and is of clinical interest. Long-term, low-dose macrolide antibiotic therapy has good safety, and no serious events have been reported; however, potential cardiac side effects and macrolide resistance should be clinically noted.

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The development of diffuse panbronchiolitis during the treatment with long-term, low-dose clarithromycin for chronic sinusitis

Cited by 2 publications

References 26 publications

Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases

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