Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

Abstract

In this research study, we will study the clinical effect of Biyuan Tongqiao granules with saline nasal irrigation for treatment of chronic sinusitis. It will also study its impacts on the computed tomography (CT) score of the nasal sinus and negative reactions in patients. For this purpose, ninety (90) patients with chronic sinusitis were admitted to the hospital (June 2019 to June 2020). They were selected as the research subjects and divided into experimental and control groups randomly with 45 cases in each group. Control group patients were treated with nasal irrigation with normal saline. While, Biyuan Tongqiao granules combined with nasal irrigation with normal saline was treated by the experimental group. The CT scores of nasal sinus, clinical effect, the incidence of adverse reactions, recurrence rate, duration of nasal mucosal epithelialization, and nasal ciliary transmission speed of both the groups were compared. The patients’ pain was assessed by the visual analogue scale (VAS), and the symptoms of sinusitis were scored by the SNOT-20 scale. The experimental group showed significantly lower sinus CT scores and better clinical effects. Adverse reactions were not observed in both the groups’ probability ( P > 0.05 ). The experimental group presented a significantly lower recurrence rate, shorter duration of nasal mucosal epithelialization, faster nasal ciliary transmission, and sharply lowers VAS scores and SNOT-20 scores than in the control group ( P < 0.05 ). This proves Biyuan Tongqiao granules and nasal irrigation with normal saline can effectually boost the clinical efficacy and lessen the computed tomography score of nasal sinus in chronic sinusitis patients. It has a worthy clinical application and promotion.

Efficacy and safety of traditional Chinese medicine nasal irrigation on chronic rhinosinusitis recovery after endoscopic sinus surgery: A protocol for a systematic review and meta-analysis

“…More and more clinical trials have evaluated the effect of TCM nasal rinse on CRS recovery after ESS, indicating that it may be an effective and safe treatment method. Studies have revealed that [20][21][22][23][24] local nasal irrigation with TCM is effective in reducing nasal mucosa edema, promoting epithelialization of surgical cavity mucosa, and promoting the recovery of nasal mucociliary structure and motor function. Moreover, the local action mechanism of TCM is not a single antibacterial and anti-inflammatory, but also related to local immune regulation.…”

“…Before and after treatment, the patient’s liver and kidney functions were normal. Only a few patients experienced nasal pain, nasal itching, and headache during nasal irrigation [ 24 – 26 ]. A systematic review published in 2011 showed the effectiveness and safety of TCM nasal irrigation for the postoperative recovery of chronic sinusitis after ESS [ 27 ].…”

Retracted: Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”