The development of biphasic chiral recognition in chiral separation

Abstract

In chiral separation, enantioseparation factor is an important parameter which influences the resolution of enantiomers. In this current overview, a biphasic chiral recognition method is introduced to the readers. This method can significantly improve the enantioseparation factor in two-phase solvent through adding lipophilic and hydrophilic chiral selectors which have opposite chiral recognition ability to organic and aqueous phases, respectively. This overview presents the development and applications of biphasic chiral recognition in liquid-liquid extraction and counter current chromatography. It mainly focuses on the topics of mechanism, advantages and limitations, applications, and key factors of biphasic chiral recognition. In addition, the future outlook on development of biphasic chiral recognition also has been discussed in this overview.

Chirality Discrimination at Binary Organic|Water Interfaces Monitored by Interfacial Tension Measurements with Preliminary Comparison with Molecular Dynamics Simulations

“…Such a combination offers a convenient way to monitor chirality discrimination process at interfaces, which has not been demonstrated before to the best of our knowledge. As highlighted in several recent reports and reviews, [16,[53][54][55] there is substantial interest in applying chiral discrimination at interfaces in the fields of electrochemical detection, biochemical sensing and supramolecular chemistry for controlling properties of chiral aggregates. The current approach can be applied to examine some of these interfaces, for example those containing β-cyclodextrin or calixarenes and amino acids to gain insights into how different factors affect the chirality discrimination outcome.…”

Enantioseparation Membranes: Research Status, Challenges, and Trends

“…[23,24] In contrast, racemic resolution is an effective method and necessary process to obtain high-purity enantiomers, and has many advantages such as simplicity, rapidness, high efficiency, and no by-products. [25][26][27][28] However, the separation of enantiomers with similar physical and chemical properties has always been a difficult problem in the field of separation. In 1848, Pastour separated crystals of left-handed and right-handed ammonium sodium tartrate, which was the first case of chiral separation.…”

A Charge-Transfer-Induced Strategy for Enantioselective Discrimination by Potential-Regulated Surface-Enhanced Raman Scattering Spectroscopy

“…Chirality exists widely in nature, and chiral compounds are closely associated with human daily life [ 1 , 2 ]. Many biomolecules, pharmaceuticals, personal care products, and agrochemicals are chiral [ 3 ].…”