The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents

Yang, Yantao; Zhu, Jun; Liao, Guochao; Xu, Hui; Yu, Bin

doi:10.2174/0929867325666171129131311

Cited by 85 publications

(17 citation statements)

References 43 publications

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“…Iron oxide nanoparticles with titanium or zinc coupling can be a very promising photocatalytic system for both UV and visible light-induced reactions [15,16]. Zn and Ti NPs as surface modifiers of Fe 2 O 4 can inhibit electron hole recombination under UV irradiation operating as an electron sink because the Fermi energy level of Zn and Ti lies below the conduction band of Fe 2 O 4 , and therefore photoexcited electrons in Fe 2 O 4 can easily transfer the charge to ZnO and TiO 2 NPs [17,18].…”

Section: Introductionmentioning

confidence: 99%

Colloidal Metal Oxide Nanoparticles Prepared by Laser Ablation Technique and Their Antibacterial Test

Duque

Madrigal

Riascos

et al. 2019

Colloids and Interfaces

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In this article we report the production of metal oxide (TiFe2O4, ZnFe2O4) nanoparticles by pulsed laser ablation technique in a liquid environment. We used nanosecond Nd: YAG laser systems working at 532 nm and 1064 nm of wavelength and the energy of the laser beam was kept constant at 80 mJ. Absorbance spectra, surface plasmon resonance, optical band-gap, and nanoparticle morphology were investigated using ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Changing the wavelength of the laser for growth, nanoparticles showed shift between the absorbance and surface plasmon resonance peaks in their UV-Vis spectra, which implies that the optical properties of the colloid nanoparticles depend on laser parameters. This was confirmed with the variation of the band gap energy. Furthermore, redshift for the absorbance peak was observed for samples as-grown at 532 nm around 150 nm as a function of time preparation. Conversely, for the samples as-grown at 1064 nm there was no shift in the absorbance spectra, which could be due to agglomeration and formation of larger particles. The characterization results showed appropriate plasmonic photo-catalysts properties of the particles, hence the photoactivation of the nanoparticles was examined on antibacterial effect using colonies of Staphylococcus aureus and Escherichia coli.

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Section: Introductionmentioning

confidence: 99%

Colloidal Metal Oxide Nanoparticles Prepared by Laser Ablation Technique and Their Antibacterial Test

Duque

Madrigal

Riascos

et al. 2019

Colloids and Interfaces

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“…All the racemic products were freshly prepared as per the method reported in the literature. 83 Thermo Scientific Nicolet iS10 FT-IR spectrometer (Thermo Fisher Scientific, Waltham, MA, USA) has been used for Infrared spectra recording. Enantiomeric ratios were determined by analytical chiral HPLC analysis on a Shimadzu LC-20A (Shimadzu, Kyoto, Japan) Prominence instrument with a chiral stationary phase using Daicel OD-H columns (Chiral Technologies Europe, Illkirch-Graffenstaden, France) and 70–75% n -hexane/isopropanol as eluents (ESI † ).…”

Section: Methodsmentioning

confidence: 99%

Cu(ii)-thiophene-2,5-bis(amino-alcohol) mediated asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization: a new highly efficient Lewis acid catalyst

et al. 2022

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“…Increasing the volume of the C7 heterocycle by maintaining the substituted methoxy-imino pyrrolidine ring resulted in a compound with acceptable side effects [ 228 ]. Various spiro compounds with antibacterial activity have been published [ 237 , 238 , 239 , 240 ].…”

Section: Compounds In Therapy Since 2000mentioning

confidence: 99%

Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

et al. 2021

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The evolution of the class of antibacterial quinolones includes the introduction in therapy of highly successful compounds. Although many representatives were withdrawn due to severe adverse reactions, a few representatives have proven their therapeutical value over time. The classification of antibacterial quinolones into generations is a valuable tool for physicians, pharmacists, and researchers. In addition, the transition from one generation to another has brought new representatives with improved properties. In the last two decades, several representatives of antibacterial quinolones received approval for therapy. This review sets out to chronologically outline the group of approved antibacterial quinolones since 2000. Special attention is given to eight representatives: besifloxacin, delafoxacin, finafloxacin, lascufloxacin, nadifloxacin and levonadifloxacin, nemonoxacin, and zabofloxacin. These compounds have been characterized regarding physicochemical properties, formulations, antibacterial activity spectrum and advantageous structural characteristics related to antibacterial efficiency. At present these new compounds (with the exception of nadifloxacin) are reported differently, most often in the fourth generation and less frequently in a new generation (the fifth). Although these new compounds’ mechanism does not contain essential new elements, the question of shaping a new generation (the fifth) arises, based on higher potency and broad spectrum of activity, including resistant bacterial strains. The functional groups that ensured the biological activity, good pharmacokinetic properties and a safety profile were highlighted. In addition, these new representatives have a low risk of determining bacterial resistance. Several positive aspects are added to the fourth fluoroquinolones generation, characteristics that can be the basis of the fifth generation. Antibacterial quinolones class continues to acquire new compounds with antibacterial potential, among other effects. Numerous derivatives, hybrids or conjugates are currently in various stages of research.

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The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents

Cited by 85 publications

References 43 publications

Colloidal Metal Oxide Nanoparticles Prepared by Laser Ablation Technique and Their Antibacterial Test

Colloidal Metal Oxide Nanoparticles Prepared by Laser Ablation Technique and Their Antibacterial Test

Cu(ii)-thiophene-2,5-bis(amino-alcohol) mediated asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization: a new highly efficient Lewis acid catalyst

Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

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