This paper explores the realms of global economic integration by comparing the two prominent international organizations: the Association of Southeast Asian Nations (ASEAN) and Brazil, Russia, India, China, and the South Africa bloc (BRICS) and new entrants to BRICS Plus. The study examines the shared objectives, divergent approaches, and potential complementarity of these organizations. By analyzing their economic diversity, regional and global initiatives, and trade agreements, the research investigates the question of collaboration between BRICS and ASEAN organizations. This research finds a variety of economic disparities among members of both ASEAN and BRICS, a variety of investment patterns, economic policies, population and labor force dynamics, net portfolio investments, and capital flows. The paper provides a nuanced holistic analysis of ASEAN and BRICS. This article offers a unique, holistic analysis, comparing and contrasting ASEAN and BRICS countries and the nature of these two organizations. This paper includes policy recommendations related to fostering collaboration between nations in various aspects of their economies, and areas in which countries may strengthen financial ties. Knowledge of BRICS, BRICS Plus, and ASEAN gained through reading this article may enable them to decide on strategies to avoid trade barriers and may also enable them to identify countries with growth areas in various economic sectors.