The Development of a WTC Environmental Health Center Pan-Cancer Database

Shao, Yongzhao; Durmuş, Nedim; Zhang, Yian; Pehlivan, Sultan; Fernandez-Beros, Maria Elena; Umana, L.; Corona, Rachel; Addessi, Adrienne; Abbott, Sharon A.; Smyth-Giambanco, Sheila; Arslan, Alan A.; Reibman, Joan

doi:10.3390/ijerph18041646

Cited by 16 publications

(36 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cancer characteristics of breast cancer patients are derived from the newly developed WTC EHC Pan-Cancer Database (PCDB) that was created to capture information on all cancer types in the WTC EHC and is linked with the current WTC EHC clinical database [ 18 ]. We utilize REDCap as a secure Federal Information Security Modernization Act (FISMA) and Health Insurance Portability and Accountability Act (HIPAA)-compliant environment to support data capture and management for the WTC EHC PCDB.…”

Section: Methodsmentioning

confidence: 99%

“…We utilize REDCap as a secure Federal Information Security Modernization Act (FISMA) and Health Insurance Portability and Accountability Act (HIPAA)-compliant environment to support data capture and management for the WTC EHC PCDB. The three main domains of the PCDB include patient demographics, site-specific cancer characteristics, and cancer biomarker information [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019

Arslan

Zhang

Durmuş

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

The destruction of World Trade Center on 11 September 2001 exposed local community members to a complex mixture of known carcinogens and potentially carcinogenic substances. To date, breast cancer has not been characterized in detail in the WTC-exposed civilian populations. The cancer characteristics of breast cancer patients were derived from the newly developed Pan-Cancer Database at the WTC Environmental Health Center (WTC EHC). We used the Surveillance, Epidemiology, and End Results (SEER) Program breast cancer data as a reference source. Between May 2002 and 31 December 2019, 2840 persons were diagnosed with any type of cancer at the WTC EHC, including 601 patients with a primary breast cancer diagnosis (592 women and 9 men). There was a higher proportion of grade 3 (poorly differentiated) tumors (34%) among the WTC EHC female breast cancers compared to that of the SEER-18 data (25%). Compared to that of the SEER data, female breast cancers in the WTC EHC had a lower proportion of luminal A (88% and 65%, respectively), higher proportion of luminal B (13% and 15%, respectively), and HER-2-enriched (5.5% and 7%, respectively) subtypes. These findings suggest considerable differences in the breast cancer characteristics and distribution of breast cancer intrinsic subtypes in the WTC-exposed civilian population compared to that of the general population. This is important because of the known effect of molecular subtypes on breast cancer prognosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019

Arslan

Zhang

Durmuş

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cancer characteristics of lung cancer patients are derived from the newly developed WTC EHC Pan-Cancer Database (PCDB), which was created to capture information on all cancer types in the WTC EHC and to interface with the current WTC EHC clinical databases [36]. We use REDCap as a secure Federal Information Security Modernization Act and Health Insurance Portability and Accountability Act -compliant environment to support data capture for the WTC EHC PCDB [37,38].…”

Section: Lung Cancer Characteristicsmentioning

confidence: 99%

“…We use REDCap as a secure Federal Information Security Modernization Act and Health Insurance Portability and Accountability Act -compliant environment to support data capture for the WTC EHC PCDB [37,38]. The three main domains of the database include patient demographics, cancer characteristics, and cancer biomarker information [36].…”

Section: Lung Cancer Characteristicsmentioning

confidence: 99%

Lung Cancer Characteristics in the World Trade Center Environmental Health Center

Durmuş

Pehlivan

Zhang

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

The destruction of the World Trade Center (WTC) towers on 11 September 2001 resulted in acute and chronic dust and fume exposures to community members, including local workers and residents, with well-described aerodigestive adverse health effects. This study aimed to characterize lung cancer in the WTC Environmental Health Center (WTC EHC) focusing on gender and smoking history. WTC EHC patients undergo an initial evaluation that includes WTC exposure information, demographics, and tobacco use. Detailed cancer characteristics are recorded from pathology reports. As of 31 December 2019, 248 WTC EHC patients had a diagnosis of lung cancer. More patients with lung cancer were women (57%) compared to men (43%). Many cases (47% women, 51% men) reported acute dust cloud exposure. Thirty-seven percent of lung cancer cases with available smoking history were never-smokers (≤1 pack-years) and 42% had a ≤5 pack-year history. The median age of cancer diagnosis in never-smoking women was 61 years compared to 66 years in men. Adenocarcinoma was more common in never-smokers compared to ever-smokers (72% vs. 65%) and in women compared to men (70% vs. 65%). We provide an initial description of lung cancers in local community members with documented exposure to the WTC dust and fumes.

show abstract

“…An elevated risk for multiple cancers has been shown for the WTC affected community members residing in South Manhattan on 9/11 (also called WTC “Survivors”). Dr. Shao et al [ 12 ] describe a new REDCap-based pan-cancer platform developed at the WTC Environmental Health Center (EHC) Data Center hosted by the New York University. This database includes pathology reports and biomarker data of 3440 confirmed cancer cases reviewed by a cancer epidemiologist, a pathologist, physicians, and biostatisticians.…”

Section: Cancermentioning

confidence: 99%