Lung Cancer Characteristics in the World Trade Center Environmental Health Center

Durmuş, Nedim; Pehlivan, Sultan; Zhang, Yian; Shao, Yongzhao; Arslan, Alan A.; Corona, Rachel; Henderson, Ian; Sterman, Daniel H.; Reibman, Joan

doi:10.3390/ijerph18052689

Cited by 8 publications

(6 citation statements)

References 47 publications

(58 reference statements)

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“…The World Trade Center Environmental Health Center conducted a study among people who were exposed and possibly inhaled dust and fumes from the destruction of the World Trade Center towers in 2001. The results showed that lung adenocarcinoma was more common in never-smokers compared to ever-smokers (72% vs. 65%) and more common in women compared to men (70% vs. 65%) (29). One study in China showed that though the proportion of lung adenocarcinoma increased in smokers and non-smokers, lung adenocarcinoma was more common in non-smokers (30).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China

Shi

Dong

et al. 2022

Front. Oncol.

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BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and treated for the first time in the investigating hospital were enrolled from 11 cities in North China between 2010 and 2017. Baseline characteristics and tumor-related information were extracted from the patients’ hospital medical record, clinical course records, and clinical examination. Some of the variables, such as smoking, alcohol consumption, medical history, and family history of cancer, were obtained from interviews with the enrolled patients. The statistical method used were the chi-square test and multi-factor logistic regression analysis. The time trend was statistically analyzed using Joinpoint regression models, and p values were calculated.ResultsA total of 23,674 lung cancer cases were enrolled. People in severely polluted cities were at higher risk for lung adenocarcinoma (p < 0.001). Most patients with lung adenocarcinoma had no history of lung-related diseases (p = 0.001). Anatomically, lung adenocarcinoma was more likely to occur in the right lung (p < 0.001). Non-manual labor workers were more likely to develop from lung adenocarcinoma than manual workers (p = 0.015). Notably, non-smokers were more likely to develop lung adenocarcinoma than smokers (p < 0.001). The proportion of lung adenocarcinoma increased significantly in Hebei Province (p < 0.001). Among non-smokers, the proportion of lung adenocarcinoma showed a higher rise than in smokers (p < 0.001).ConclusionsLung adenocarcinoma is the most common histological type of lung cancer in North China (Hebei Province), and the proportion of lung adenocarcinoma is increasing, especially among non-smokers. Lung adenocarcinoma is more common in women, severely polluted cities, individuals with no history of lung-related diseases, in the right lung, and in non-smokers. These can serve as a great guide in determining the accuracy of lung adenocarcinoma high-risk groups and lung cancer risk assessment models.

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Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China

Shi

Dong

et al. 2022

Front. Oncol.

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“…The characteristics of lung cancers in the WTC EHC were previously described by our group, demonstrating that more than half of all lung cancers occurred in women, and of these, a high proportion were noted in never-smokers (48%) [27]. This is particularly important given the reported 15% incidence of lung cancer in women never-smokers in the U.S. [28].…”

Section: Discussionmentioning

confidence: 56%

Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center

Shum

Durmuş

Pehlivan

et al. 2022

IJERPH

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The destruction of the World Trade Center towers on 11 September 2001 exposed local residents, workers, and individuals in the area (Survivors) to dust and fumes that included known and suspected carcinogens. Given the potential for inhalation of toxic substances and the long latency after exposure, the incidence of lung cancer is expected to increase in WTC-exposed individuals. We describe the characteristics of women WTC Survivors with lung adenocarcinoma who were enrolled in the WTC Environmental Health Center (WTC EHC) between May 2002 and July 2021. A total of 173 women in WTC EHC had a diagnosis of any type of lung cancer, representing 10% of all cancers in women. Most of the lung cancers (87%) were non-small cell carcinomas, with adenocarcinoma (77%) being the most common subtype. Nearly half (46%) of these patients were exposed to dust clouds on 11 September 2001. Race and ethnicity varied by smoking status, as follows: 44% of Asian women compared with 29% of non-Hispanic White women were never-smokers (p < 0.001). There was no significant difference between the pathologic characteristics of adenocarcinomas between never and ever smokers. We also summarize EGFR, ALK, KRAS, ROS-1 and BRAF mutation status stratified by smoking, race and ethnicity. The identification of a relatively high proportion of women never-smokers with lung cancer warrants further investigation into the role of WTC dust exposure.

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“…Additionally, we identified biomarkers that were associated with WTC exposure. Our group and others have previous established association of WTC exposures with LRS, cancer, mental health disorders, neuropathic symptoms, and cognitive declines in WTC survivors [35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Discussionmentioning

confidence: 65%

Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms

Grünig

Durmuş

Zhang

et al. 2022

IJERPH

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The destruction of the World Trade Center (WTC) on September 11, 2001 (9/11) released large amounts of toxic dusts and fumes into the air that exposed many community members who lived and/or worked in the local area. Many community members, defined as WTC survivors by the federal government, developed lower respiratory symptoms (LRS). We previously reported the persistence of these symptoms in patients with normal spirometry despite treatment with inhaled corticosteroids and/or long-acting bronchodilators. This report expands upon our study of this group with the goal to identify molecular markers associated with exposure and heterogeneity in WTC survivors with LRS using a selected plasma biomarker approach. Samples from WTC survivors with LRS (n = 73, WTCS) and samples from healthy control participants of the NYU Bellevue Asthma Registry (NYUBAR, n = 55) were compared. WTCS provided information regarding WTC dust exposure intensity. Hierarchical clustering of the linear biomarker data identified two clusters within WTCS and two clusters within NYUBAR controls. Comparison of the WTCS clusters showed that one cluster had significantly increased levels of circulating matrix metalloproteinases (MMP1, 2, 3, 8, 12, 13), soluble inflammatory receptors (receptor for advanced glycation end-products-RAGE, Interleukin-1 receptor antagonist (IL-1RA), suppression of tumorigenicity (ST)2, triggering receptor expressed on myeloid cells (TREM)1, IL-6Ra, tumor necrosis factor (TNF)RI, TNFRII), and chemokines (IL-8, CC chemokine ligand- CCL17). Furthermore, this WTCS cluster was associated with WTC exposure variables, ash at work, and the participant category workers; but not with the exposure variable WTC dust cloud at 9/11. A comparison of WTC exposure categorial variables identified that chemokines (CCL17, CCL11), circulating receptors (RAGE, TREM1), MMPs (MMP3, MMP12), and vascular markers (Angiogenin, vascular cell adhesion molecule-VCAM1) significantly increased in the more exposed groups. Circulating biomarkers of remodeling and inflammation identified clusters within WTCS and were associated with WTC exposure.

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Lung Cancer Characteristics in the World Trade Center Environmental Health Center

Cited by 8 publications

References 47 publications

Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China

Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China

Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center

Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms

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