The development and tendency of depression researches: Viewed from the microbiota-gut-brain axis

Liang, Shan; Wu, Xiaoli; Xu, Huibin; Niu, Yunxia; Jin, Feng

doi:10.1360/n972017-01182

Cited by 7 publications

(9 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The gut and gut microbiota work together to perform the tasks of digestion, immune and endocrine functions, and neurotransmission ( Forsythe et al, 2010 ; Lyte, 2010 ; Nicholson et al, 2012 ; Sudo, 2014 ; Ridaura and Belkaid, 2015 ). We call this microbial organ gut-brain because, unlike other peripheral organs, it can work without instructions from the brain, and this specificity can easily be found in the persistent vegetative state ( Liang et al, 2012 ; Liang et al, 2018a , b ). The gut-brain not only completes its local function, but also regulates human behavior and cognition, similar to the brain ( Grenham et al, 2011 ; Collins et al, 2012 ; Mayer et al, 2014a ; Foster et al, 2016 ).…”

Section: Gut Microbiota Gut-brain and Gut-brain Psychologymentioning

confidence: 99%

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Shen

Jin

2018

Front. Integr. Neurosci.

Self Cite

196

159

View full text Add to dashboard Cite

Mental disorders and neurological diseases are becoming a rapidly increasing medical burden. Although extensive studies have been conducted, the progress in developing effective therapies for these diseases has still been slow. The current dilemma reminds us that the human being is a superorganism. Only when we take the human self and its partner microbiota into consideration at the same time, can we better understand these diseases. Over the last few centuries, the partner microbiota has experienced tremendous change, much more than human genes, because of the modern transformations in diet, lifestyle, medical care, and so on, parallel to the modern epidemiological transition. Existing research indicates that gut microbiota plays an important role in this transition. According to gut-brain psychology, the gut microbiota is a crucial part of the gut-brain network, and it communicates with the brain via the microbiota–gut–brain axis. The gut microbiota almost develops synchronously with the gut-brain, brain, and mind. The gut microbiota influences various normal mental processes and mental phenomena, and is involved in the pathophysiology of numerous mental and neurological diseases. Targeting the microbiota in therapy for these diseases is a promising approach that is supported by three theories: the gut microbiota hypothesis, the “old friend” hypothesis, and the leaky gut theory. The effects of gut microbiota on the brain and behavior are fulfilled by the microbiota–gut–brain axis, which is mainly composed of the nervous pathway, endocrine pathway, and immune pathway. Undoubtedly, gut-brain psychology will bring great enhancement to psychology, neuroscience, and psychiatry. Various microbiota-improving methods including fecal microbiota transplantation, probiotics, prebiotics, a healthy diet, and healthy lifestyle have shown the capability to promote the function of the gut-brain, microbiota–gut–brain axis, and brain. It will be possible to harness the gut microbiota to improve brain and mental health and prevent and treat related diseases in the future.

show abstract

Section: Gut Microbiota Gut-brain and Gut-brain Psychologymentioning

confidence: 99%

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Shen

Jin

2018

Front. Integr. Neurosci.

Self Cite

196

159

View full text Add to dashboard Cite

show abstract

“…As a key component of the gut brain, gut microbiota influences the development and maturation of the HPA axis [134], affects the development and function of the immune system [135], regulates the blood-brain barrier [136], modulates the synthesis and recognition of neurotransmitters [73], regulates neurogenesis, formation of myelination [137], and supports the development and function of the brain [78]. Microbiota-gutbrain axis plays a crucial role for manifestation of mental disorders [103].…”

Section: Discussionmentioning

confidence: 99%

“…In turn, the emerging brain changes provide feedback on the gut. Uniting the brain and the colon, the brain as targeting gut microbiota organ is becoming a key trend in neuroscience and reliable field for successful management of neuropsychological disorders [11,103].…”

Section: Discussionmentioning

confidence: 99%

“…There are evidences for altered intestinal permeability in patients with mood disorder and their first degree relatives [18]. For most of the depressed patients the brain-gut axis function is impaired, including imbalance in brain neurotransmitters, decline of brain neuroplasticity, dysfunction of hypothalamic-pituitary-adrenal axis, chronic periphery inflammation and neuroinflammation, as well as gastrointestinal diseases and gut microbiota dysbiosis [103]. However, the impact of depression on the microbiota has not yet been studied [25].…”

Section: Role Of Microbiota-gut-brain Axis In Mood Disordermentioning

confidence: 99%

See 1 more Smart Citation

Influence of Gut Microbiota on Behavior and Its Disturbances

Ignatova¹

2019

Behavioral Neuroscience

View full text Add to dashboard Cite

Hippocrates statement that "All disease begins in the gut" continues to be up to date more than 2000 years later. Growing number of scientific reports focus on the important role of intestinal microorganisms for modulation of many systems and human behavior. As a key component of the gut brain, gut microbiota influences the development and maturation of the hypothalamic-pituitary-adrenal axis, affects the development and function of the immune system, regulates the blood-brain barrier, modulates the synthesis and recognition of neurotransmitters, regulates neurogenesis, formation of myelination and supports the development and function of the brain. Disruption of gut-brain axis function is associated with alterations in the stress response and might contribute to neuropsychiatric diseases as depression, autistic spectrum disorders, rapid eye movement sleep behavior disorder, Parkinson disease, Alzheimer disease and other mental conditions. Studies in animal models are crucial for guiding research on brain-gut-microbiome axis in humans, as the impact of microbiota on specific brain regions and aspects of animal behavior will help in the selection of tasks for cognitive assessment. Exploring the interaction of gut microbes and human brain will not only allow us to better understand the pathogenesis of neuropsychiatric disorders, but will also provide us new opportunities for the design of novel immuno-or microbe-based therapies.

show abstract

“…, 动物研究中发现的抑郁对于疼痛感知的多样性调节作用可能源自抑郁模型的差异以及疼痛类型的不同 [3] , JNK 在抑郁症中的作用机制及以 JNK 为靶点研究和治疗抑郁症的意义和可行性 [4] , 抑郁症患病率与菌-肠-脑轴功能异常的关系以及通过调节肠道微生物来提升肠脑状态进而治疗心理疾病的可行性 [5] , 从不同层面和角度展示出抑郁症研究未来的研究方向和发展趋势. 专辑收录 7 篇研究论文.…”

unclassified

研究抑郁, 破除在人心深处肆虐的雾霾

傅¹

2018

Chin. Sci. Bull.

View full text Add to dashboard Cite

show abstract

The development and tendency of depression researches: Viewed from the microbiota-gut-brain axis

Cited by 7 publications

References 85 publications

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Influence of Gut Microbiota on Behavior and Its Disturbances

研究抑郁, 破除在人心深处肆虐的雾霾

Contact Info

Product

Resources

About