The developmemt of myasthenia gravis after removal of thymoma

Green, Robert A.; Booth, Carl B.

doi:10.1016/0002-9343(58)90035-4

Cited by 18 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Post-thymectomy MG has been hypothesized to occur in patients with recurrence of thymoma. 5,6 Medications such as aminoglycoside antibiotics and some neuromuscular blocking agents used during surgery have exacerbate MG symptoms, and the use of non-depolarizing muscle relaxants may cause a postoperative onset of MG in patients with thymoma. 18 However, no recurrence of thymoma occurred in our six post-thymectomy patients with MG and they had not received any of these types of medications.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Myasthenia gravis appearing after thymectomy

Sun

Wang

Liu

et al. 2011

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…4 Thymectomy is recommended for patients with either disease, but a few patients with thymoma with no sign of MG before the operation have been reported to develop MG after thymectomy. [5][6][7][8][9] The mechanisms underlying this type of myasthenia gravis are obscure.…”

Section: Introductionmentioning

confidence: 99%

Myasthenia gravis appearing after thymectomy

Sun

Wang

Liu

et al. 2011

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…Thymoma is associated with several autoimmune diseases, but most vitally MG,2 and thymectomy has become an important aspect of MG management. However, the first onset of myasthenic symptoms has been reported in rare cases as late as months to years after thymectomy 3–14. We report an illustrative case that highlights the importance of reviewing thymoma patients for development of MG symptoms, especially in the complex setting of being a distant hospital to that of the original operating team.…”

Section: Introductionmentioning

confidence: 86%

Post-thymectomy myasthenia gravis: a case report and systematic review of literature

et al. 2021

View full text Add to dashboard Cite

Myasthenia gravis (MG) is an autoimmune condition affecting the neuromuscular junction characterised by weakness and fatiguability, carrying a high morbidity if treatment is delayed. A clear association with thymoma has led to management with thymectomy as a common practice, but MG presenting post-thymectomy has rarely been reported. We present a case of an 82- year-old woman developing fatigue, ptosis and dysarthria 3 months after thymectomy. After a clinical diagnosis of MG was made, she responded well to prompt treatment with prednisolone and pyridostigmine. Her anti-acetylcholine receptor antibody (anti-AChR) subsequently came back positive. Our systematic review reveals that post-thymectomy MG can be categorised as early-onset or late-onset form with differing aetiology, and demonstrated correlation between preoperative anti-AChR titres and post-thymectomy MG. The postulated mechanisms for post-thymectomy MG centre around long-lasting peripheral autoantibodies. Clinicians should actively look for MG symptoms in thymoma patients and measure anti-AChR preoperatively to aid prognostication.

show abstract

“…The current hypothesis of the pathogenic mechanism of PTMG includes: [1]thymoma recurrence (7,8); [2] surgical exposure to larval MG (2); and [3]activation of peripheral lymphocytes from thymoma after surgery (9,10). The risks of developing PTMG have been documented in various studies.…”

Section: Discussionmentioning

confidence: 99%

“…However, Myasthenia Gravis occasionally develops postoperatively in patients who have had thymoma despite no signs of Myasthenia Gravis before the surgery. Some studies (1-8) have reported post-thymectomy Myasthenia Gravis (PTMG); however, its mechanism and risk factors remain unclear. Moreover, no case of PTMG with onset at Osserman stage III has been reported.…”

Section: Introductionmentioning

confidence: 99%

Post-thymectomy myasthenia gravis with an episode of Osserman stage III

Kuwata

Iwata

Iwanami

2012

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Here, we present the first case of post-thymectomy Myasthenia Gravis with onset at Osserman stage III. An 81-year-old woman was admitted for an abnormal shadow seen in a chest radiograph. She had no symptoms of Myasthenia Gravis. Acetylcholine receptor antibody was within the normal range. Chest computed tomography (CT) showed a bulky anterior mediastinal tumor. She was diagnosed as having thymoma by tissue biopsy under CT guidance. The tumor was completely resected by performing thymothymectomy, left upper lobectomy, pericardial resection, and phrenicectomy. Pathological examination of the tumor identified it as a thymoma (type B2, Masaoka stage II). Two months after the surgery, she experienced the onset of post-thymectomy myasthenia gravis with Osserman stage III. The acetylcholine receptor antibody level was remarkably elevated (220 nmol/L); however, there was no evidence of tumor recurrence.

show abstract

The developmemt of myasthenia gravis after removal of thymoma

Cited by 18 publications

References 36 publications

Myasthenia gravis appearing after thymectomy

Myasthenia gravis appearing after thymectomy

Post-thymectomy myasthenia gravis: a case report and systematic review of literature

Post-thymectomy myasthenia gravis with an episode of Osserman stage III

Contact Info

Product

Resources

About