Abstract:Previous research testifies that c‐Myc may promote keloid fibroblast proliferation and collagen accumulation. Ubiquitin‐specific peptidase 37 (USP37)‐mediated deubiquitination and stabilisation of c‐Myc are vital for lung cancer proliferation, while the potential role of USP37 in keloid fibroblasts is not investigated. Elevated USP37, c‐Myc, and Collagen I content were detected in keloid tissue with RT‐PCR or ELISA assay. USP37 over‐expression plasmids or USP37 short hairpin RNAs (shRNAs) were transfected into… Show more