The determination of warfarin in animal relicta

A Flow-through Sensing Device with Fluorometric Transduction for the Determination of Warfarin by Using an Anion-Exchanger Gel Combined with an FIA System

“…The limit of detection, DL (K = 3) and the limit of quantification, QL (K = 10) are also reported in Table 1, where K is a numerical factor chosen in accordance with the confidence level desired. 21 The proposed method compares very favorably with spectrophotometric, spectrofluorometric and phosphorimetric methods [6][7][8][9][10] in terms of sensitivity and DL because their detection limits are not lower than 1 µg ml -1 . An additional advantage of the proposed method is its ability to determine warfarin in aqueous media without derivatization or previous extraction processes.…”

“…Direct measurements of warfarin using spectrophotometric methods are also used. 6,7 Moreover, its native luminiscence also allows its direct determination by conventional spectrofluorometry 8 and phosphorimetry. 9 They are simpler than chromatographic methods, but usually have poor specificity and sensitivity (detection limits in the range 1 -10 µg ml -1 ).…”

Ultraviolet spectrometry

“…Griffin and Blazek (245) extracted 2-pivalyl-l,3-indandione (Rival) from rodenticide formulations with an alkaline buffer and then into cyclohexane after acidification. Fishwick and Taylor (201) extracted the rodenticide, warfarin, from biological material. 188) analyzed fractions obtained by countercurrent distribution of neutral oils from coal tar.…”

Anti-warfarin antibody preparation and its characterization for radioimmunoassay

“…Earlier methods for determination of warfarin concentrations in plasma are laborious, since they were based on native fluorescence (Lewis et a1 1970), phosphorescence (Bridges 1974) or absorption (Fishwick & Taylor 1967) of the drug and therefore, required its extraction and separation from other drugs in the plasma.…”