The determination method of malonal generation degree of oxidized squalene

Witas, T.; Wedzińska, J.

doi:10.1002/food.19790230604

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…When human skin is directly exposed to ultraviolet light, the skin surface lipids are easily peroxidized. In particular, squalene, which is the main component of skin surface polyunsaturated lipids, is easily peroxidized (1)(2)(3)(4)(5). Squalene-peroxides are reportedly comedogenic substances that are produced by ultraviolet irradiation (6,7).…”

Section: Introductionmentioning

confidence: 99%

Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse

Chiba

Sone

Kawakami

et al. 1999

Experimental Dermatology

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The present study examines the cumulative effects of sub-erythema application of squalene-monohydroperoxide (Sq-OOH), the initial products of UV-peroxidated squalene, to the skin of hairless mice. Sq-OOH was isolated by the methanol extraction and preparative HPLC method. Repeated topical application of 10 mM Sq-OOH to hairless mice for 3 weeks induced definite skin roughness and crinkle formation. 3-D surface parameter analysis revealed changes in all roughness parameters (number of furrows and crests, distance between a furrow and next crest, and irregularity) of the group treated with more than 3 mM Sq-OOH compared to the control group. These skin surface changes were not induced by squalene, squalene-monohydroxide (Sq-OH) or organic hydroperoxides such as tert-butyl hydroperoxide and cumene-hydroperoxide at 10 mM. Similarly, such changes were not induced by primary irritants, such as sodium lauryl sulfate and n-tetradecane under the same experimental conditions. Skin conductance decreased, following application of 10 mM Sq-OOH. Histological observation revealed that application of 10 mM Sq-OOH induced slight hyperkeratosis, moderate epidermal thickening and slight hyperplasia of sebaceous glands.

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Section: Introductionmentioning

confidence: 99%

Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse

Chiba

Sone

Kawakami

et al. 1999

Experimental Dermatology

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The optimum condition for malonic dialdehyde liberation from smoked fish and curing smoke condensates

Witas¹,

Sledziewski²

1988

Nahrung

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The aim of this study was to establish the conditions for malonic dialdehyde liberation from smoked fish and curing smoke condensates, as well as to determine its content in smoked fish. The specific absorption peaks of coloured solutions of malonic dialdehyde, from curing smoke condensates, with 2-thiobarbituric acid were determined. The conditions for malonic dialdehyde liberation were established, i.e. time and degree of alkaline hydrolysis of condensate, degree of distillation of acidified condensate solution, the conditions of coloured solution development, determination of extinction and method of calculation of malonic dialdehyde content in smoked fish, in individual layers of smoked mackerel fillets. The mechanism of formation of polycyclic aromatic hydrocarbone and hydrogen peroxide or hydroxyl free radicals, formed during pyrolysis of organic compounds in the presence of liberated malonic dialdehyde, was proposed.

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Exhalation of malondialdehyde from the smoke of high grade cigarettes and effectiveness of filtering it

Witas¹,

Sledziewski²

1990

Nahrung

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It has been found that malondialdehyde penetrates during smoking through filters and exhales with smoke from cigarettes such as: "Pall Mall", "Winston", "Camel", "Lucky Strike", "Kansas", "Mustang", "Ronson", "Chesterfield", "Rally", "Oscar" and "Marlboro". These cigarettes exhale malondialdehyde in a different way, in free form in the amount from 8.5 to 23.5 mg/kg cigarettes on an average of 13.3 mg/kg for the whole group and totally (in free and bounded form) from 9.5 to 26.5 mg/kg (average 16.9 mg/kg). Moreover, it has been found that filters retain this aldehyde in free form on an average of 9.9 mg/kg and totally (in free and bounded form) of 19.0 mg/kg. Without filters these amounts would increase aldehyde contents in smoke by 42.7 and 52.9%, respectively. Low malonalogenic properties of tobacco, high effectiveness of cigarette filters, high degree of tar deposition before inhaling into lungs and slow (6 min and longer) smoking decide about low level of exhalation of malondialdehyde in cigarette smoke.

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The determination method of malonal generation degree of oxidized squalene

Cited by 5 publications

References 12 publications

Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse

Skin roughness and wrinkle formation induced by repeated application of squalenemonohydroperoxide to the hairless mouse

The optimum condition for malonic dialdehyde liberation from smoked fish and curing smoke condensates

Exhalation of malondialdehyde from the smoke of high grade cigarettes and effectiveness of filtering it

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