The detection of significant prostate cancer is correlated with the Prostate Imaging Reporting and Data System (PI-RADS) in MRI/transrectal ultrasound fusion biopsy

Cash, Hannes; Maxeiner, Andreas; Stephan, Carsten; Fischer, Thomas; Durmus, Tahir; Holzmann, Josephine; Asbach, Patrick; Haas, Matthias; Hinz, Stefan; Neymeyer, J.; Miller, Kurt; Günzel, Karsten; Kempkensteffen, Carsten

doi:10.1007/s00345-015-1671-8

Cited by 100 publications

(94 citation statements)

References 32 publications

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“…Interestingly, in the present cohort, the detection rate of PCa with a GS ≥7 was >50% in lesions classified as PI-RADS ≤2. In their study of 408 men undergoing combined MRI/ultrasonography-fusion PBx and systematic PBx, Cash et al [6] reported an overall detection rate of 16% in lesions classified as PI-RADS ≤2 (32 patients).…”

Section: Discussionmentioning

confidence: 99%

“…MRI/ultrasonography-fusion or in-bore MRI prostate biopsy (PBx) can be used for targeted biopsy [3][4][5]. The Prostate Imaging Reporting and Data System (PI-RADS) classification, which was introduced in 2012, provides a framework for standardized reporting of findings in mpMRI of the prostate and has quickly gained widespread acceptance [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Direct comparison of multiparametric magnetic resonance imaging (MRI) results with final histopathology in patients with proven prostate cancer in MRI/ultrasonography‐fusion biopsy

et al. 2016

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ObjectiveTo compare multiparametric magnetic resonance imaging (mpMRI) of the prostate and histological findings of both targeted MRI/ultrasonography-fusion prostate biopsy (PBx) and systematic PBx with final histology of the radical prostatectomy (RP) specimen. Patients and MethodsA total of 105 patients with prostate cancer (PCa) histopathologically proven using a combination of fusion Pbx and systematic PBx, who underwent RP, were investigated. All patients had been examined using mpMRI, applying the European Society of Urogenital Radiology criteria. Histological findings from the RP specimen were compared with those from the PBx. Whole-mount RP specimen and mpMRI results were directly compared by a uro-pathologist and a uro-radiologist in step-section analysis. ResultsIn the 105 patients with histopathologically proven PCa by combination of fusion PBx and systematic PBx, the detection rate of PCa was 90% (94/105) in fusion PBx alone and 68% (72/105) in systematic PBx alone (P = 0.001). The combination PBx detected 23 (22%) Gleason score (GS) 6, 69 (66%) GS 7 and 13 (12%) GS ≥8 tumours. Fusion PBx alone detected 25 (26%) GS 6, 57 (61%) GS 7 and 12 (13%) GS ≥8 tumours. Systematic PBx alone detected 17 (24%) GS 6, 49 (68%) GS 7 and 6 (8%) GS ≥8 tumours. . The rates of concordance with regard to GS between the PBx and RP specimen were 63% (n = 65), 54% (n = 56) and 75% (n = 78) in fusion, systematic and combination PBx (fusion and systematic PBx combined), respectively. Upgrading of the GS between PBx and RP specimen occurred in 33% (n = 34), 44% (n = 46) and 18% (n = 19) in fusion, systematic and combination PBx, respectively. c-correlation for detection of any cancer was 0.76 for combination PBx, 0.68 for fusion PBx alone and 0.23 for systematic PBx alone. In all, 84% (n = 88) of index tumours were identified by mpMRI; 86% (n = 91) of index lesions on the mpMRI were proven in the RP specimen. ConclusionsFusion PBx of tumour-suspicious lesions on mpMRI was associated with a higher detection rate of more aggressive PCa and a better tumour prediction in final histopathology than systematic PBx alone; however, combination PBx had the best concordance for the prediction of GS. Furthermore, the additional findings of systematic PBx reflect the multifocality of PCa, therefore, the combination of both biopsy methods would still represent the best approach for the prediction of the final tumour grading in PCa. KeywordsMRI/ultrasound-fusion biopsy, prostate cancer, multiparametric MRI, prostatectomy specimen, systematic biopsy, direct comparison

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct comparison of multiparametric magnetic resonance imaging (MRI) results with final histopathology in patients with proven prostate cancer in MRI/ultrasonography‐fusion biopsy

et al. 2016

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“…По данным H. Cash и соавт., ее использование совместно с мпМРТ пока-зывает высокую выявляемость РПЖ среднего и высо-кого рисков [16]. Были обследованы 408 пациентов в период с 2012 по 2015 г. Распределение согласно гра-дации PI-RADS: PI-RADS 2 -8 % (n = 32), PI-RADS 3 -28 % (n = 113), PI-RADS 4 -37 % (n = 152) и PI-RADS 5 -27 % (n = 111).…”

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The use of MRI/ultrasound fusion biopsy in the diagnosis of clinically significant prostate cancer

Kossov¹,

Камолов²,

Абдуллин³

et al. 2017

Cancer Urology

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Контакты: Филипп Андреевич Коссов fil-doc@yandex.ru Введение. Стандартная биопсия предстательной железы (ПЖ) с последующей гистологической верификацией в настоящее вре-мя является неотъемлемой частью диагностики рака ПЖ (РПЖ),

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“…Similar fusion techniques have already been established for targeted biopsies of the prostate (11). In a recent feasibility study, MRI-TRUS fusion was used for planning of focal ablative therapy for prostate cancer with high-intensity focused ultrasound (12).…”

Section: Discussionmentioning

confidence: 99%

MRI-TRUS fusion for electrode positioning during irreversible electroporation for treatment of prostate cancer

Baur

Collettini²,

Enders³

et al. 2017

Diagn Interv Radiol

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The detection of significant prostate cancer is correlated with the Prostate Imaging Reporting and Data System (PI-RADS) in MRI/transrectal ultrasound fusion biopsy

Cited by 100 publications

References 32 publications

Direct comparison of multiparametric magnetic resonance imaging (MRI) results with final histopathology in patients with proven prostate cancer in MRI/ultrasonography‐fusion biopsy

Direct comparison of multiparametric magnetic resonance imaging (MRI) results with final histopathology in patients with proven prostate cancer in MRI/ultrasonography‐fusion biopsy

The use of MRI/ultrasound fusion biopsy in the diagnosis of clinically significant prostate cancer

MRI-TRUS fusion for electrode positioning during irreversible electroporation for treatment of prostate cancer

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