MRI-TRUS fusion for electrode positioning during irreversible electroporation for treatment of prostate cancer

Baur, Alexander; Collettini, Federico; Enders, Judith; Maxeiner, Andreas; Schreiter, Vera; Stephan, Carsten; Gebauer, Bernhard; Hamm, B.; Fischer, Thomas

doi:10.5152/dir.2017.16276

Cited by 11 publications

(11 citation statements)

References 14 publications

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“…The IRE procedure consists of different phases, including patient preparation, field visualisation, device set-up, needle insertion, and treatment delivery. All phases of the procedure have been described in the literature and are performed in an operating theatre [9][10][11][12].…”

Section: Ire Techniquementioning

confidence: 99%

“…A trans-rectal ultrasound probe is inserted and the prostate's threedimensional measures are observed (axial, sagittal, and coronal planes) [9]. Anatomical landmarks, including the urethra, urinary bladder neck, prostatic-seminal vesicle angles, external sphincter, and the edge of the prostate base, are identified and marked in both the sagittal and axial plane [9,10]. The target lesion and its location relative to the other structures is also visualised in an axial plane grid [9].…”

Section: Ire Techniquementioning

confidence: 99%

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Irreversible Electroporation for Prostate Cancer

Ong

Leonardo

Chengodu

et al. 2021

Life

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Although it can be lethal in its advanced stage, prostate cancer can be effectively treated when it is localised. Traditionally, radical prostatectomy (RP) or radiotherapy (RT) were used to treat all men with localised prostate cancer; however, this has significant risks of post-treatment side effects. Focal therapy has emerged as a potential form of treatment that can achieve similar oncological outcomes to radical treatment while preserving functional outcomes and decreasing rates of adverse effects. Irreversible electroporation (IRE) is one such form of focal therapy which utilises pulsatile electrical currents to ablate tissue. This modality of treatment is still in an early research phase, with studies showing that IRE is a safe procedure that can offer good short-term oncological outcomes whilst carrying a lower risk of poor functional outcomes. We believe that based on these results, future well-designed clinical trials are warranted to truly assess its efficacy in treating men with localised prostate cancer.

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Section: Ire Techniquementioning

confidence: 99%

Section: Ire Techniquementioning

confidence: 99%

Irreversible Electroporation for Prostate Cancer

Ong

Leonardo

Chengodu

et al. 2021

Life

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“…The IRE procedures were performed by using a commercially available IRE generator (NanoKnife; Angiodynamics, New York, NY). The interventional technique was previously described in detail in a technical note addressing the use of MRI-transrectal US-fusion technique for electrode placement in 10 participants included in our study without reference to or consideration of any data about the safety or effectiveness of the therapy itself (11).…”

mentioning

confidence: 99%

Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes

et al. 2019

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Background: Irreversible electroporation (IRE) is a nonthermal ablative method based on the formation of nanoscale defects in cell membranes leading to cell death. Clinical experience with the technique for treatment of prostate cancer remains limited. Purpose: To evaluate urogenital toxicity and oncologic outcome of MRI-transrectal US fusion-guided IRE of localized prostate cancer. Materials and Methods: In this prospective study, men with biopsy-proven, treatment-naive, low-to intermediate-risk prostate cancer (prostate-specific antigen [PSA], 15 ng/mL; Gleason score, 3 + 4; clinical stage, T2c; lesion size at multiparametric MRI, 20 mm) underwent focal MRI/transrectal US fusion-guided IRE between July 2014 and July 2017. Primary end point was the urogenital toxicity profile of focal IRE by using participant-reported questionnaires. Secondary end points were biochemical, histologic, and imaging measures of oncologic control. Analyses were performed by using nonparametric and x 2 test statistics. Results: Thirty men were included (median age, 65.5 years); mean PSA level was 8.65 ng/mL and mean tumor size was 13.5 mm. One grade III adverse event (urethral stricture) was recorded. The proportion of men with erection sufficient for penetration was 83.3% (25 of 30) at baseline and 79.3% (23 of 29; P. .99) at 12 months. Leak-free and pad-free continence rate was 90% (27 of 30) at baseline and 86.2% (25 of 29; P. .99) at 12 months. Urogenital function remained stable at 12 months according to changes in the modified International Consultation on Incontinence Questionnaire Male Lower Urinary Tract Symptoms, or ICIQ-MLUTS, and the International Index of Erectile Function, or IIEF-5, questionnaires (P = .58 and P = .07, respectively). PSA level decreased from a baseline median value of 8.65 ng/mL (interquartile range, 5-11.4 ng/mL) to 2.35 ng/mL (interquartile range, 1-3.4 ng/mL) at 12 months (P , .001). At 6 months, 28 of 30 participants underwent posttreatment biopsy. The rate of infield treatment failure was 17.9% (five of 28) as determined with multiparametric prostate MRI and targeted biopsies at 6 months. Conclusion: After a median follow-up of 20 months, focal irreversible electroporation of localized prostate cancer was associated with low urogenital toxicity and promising oncologic outcomes.

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“…The role of fusion imaging technology in Gynecology and Obstetrics field has not yet been defined. Other medical applications were more experienced in urology [25][26][27][28][29][30][31][32], hepatology [33,34] and breast pathology [35][36][37][38][39][40]. CE-MRI has become an essential technique in this field breast cancer, a disease with an incidence of 37,000 new cases/year in Italy [35], that affects 1 woman on 10 and represents 25% of all tumors in females [36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Real-Time Virtual Sonography in Gynecology & Obstetrics: Literature’s Analysis and Case Series

Torcia¹,

Bellati²,

Marco³

et al. 2018

BJSTR

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Real-Time Virtual Sonography is performed using pictures obtained from preoperative MRI or CT scan with the aim to study pathologies in an integrated way. This new technique allows to synchronize with a single device, through the same software, two or more imaging methods, overlapping and activating them with the simple classic movement of the ultrasound transducer. The software includes a magnetic field transmitter which sends signals to a position sensor placed on a suitable support that wraps the selected probe. The magnetic field transmitter should be placed close to the area to be evaluated. During scanning, the magnetic detection system determines the position and movement of the

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MRI-TRUS fusion for electrode positioning during irreversible electroporation for treatment of prostate cancer

Cited by 11 publications

References 14 publications

Irreversible Electroporation for Prostate Cancer

Irreversible Electroporation for Prostate Cancer

Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes

Real-Time Virtual Sonography in Gynecology & Obstetrics: Literature’s Analysis and Case Series

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