The detection of HBV antigens and HBx‐transcripts in an Indian fibrolamellar carcinoma patient: a case study

Dadke, Disha; Jaganath, P.; Krishnamurthy, Sarala; Chiplunkar, Shubhada V.

doi:10.1046/j.0106-9543.2001.01602.x

Cited by 15 publications

(6 citation statements)

References 16 publications

(16 reference statements)

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“…However, Craig, Berman and others reported cases with a mixture of FL‐HCC and conventional HCC, as seen in the present case 1,2 . There is also a report of the transformation of FL‐HCC to conventional HCC in the recurrent lesions, 4 and another report suggests an oncogenic role of HBV in FL‐HCC 5 . These facts might suggest that there is a different category of FL (‐like) HCC, which occurred in the same carcinogenic pathway as conventional HCC.…”

supporting

confidence: 53%

Fibrolamellar Carcinoma of the Liver in a Japanese Hepatitis B Virus Carrier

Morise¹,

Sugioka²,

Mizoguchi

et al. 2005

J of Gastro and Hepatol

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Temporal bone metastasis would be rare. Although the occurrence of facial nerve palsy is frequently a result of cranial bone metastasis in a patient with cancer, the incidence of facial nerve palsy as a consequence of temporal bone metastasis is rare. When facial nerve palsy is accompanied by other cranial nerve palsies, especially of the neighboring cranial nerves V and VIII, temporal bone metastasis should be suspected. 1 We report here a rare patient with facial nerve palsy due to temporal bone metastasis from hepatocellular carcinoma (HCC).A 49-year-old man, with hepatitis B virus-related liver cirrhosis, had suffered from ascites for several years. He was admitted to our unit in February 2003 because of upper gastrointestinal bleeding secondary to esophageal varices. Hemostasis was achieved by endoscopic ligation of the varices. The liver disease based on routine liver function tests was classified as Child-Pugh Grade C. Abdominal computed tomography (CT) showed a small low-density area in the medial part of the liver, but no enhancement throughout dynamic study (Fig. 1a). Alpha-fetoprotein (AFP) was 39 ng/ mL, and protein induced by vitamin K deficiency and antagonist-II (PIVKA-II) was 118 mAU/mL. At that time, no further examination was performed.One to 3 days later, the patient presented with rightsided facial weakness with pain, showing peripheral paresis of the right facial nerve. There was no history of previous neurological deficit, and laboratory tests showed no evidence of viral infection such as cytomegalovirus or herpes virus. One month later, the symptoms and pain progressively worsened with trachyphonia and dysphagia. Neurological examination revealed right V, VII, VIII, IX, XI and XII cranial nerve palsies. Non-contrast CT of the brain showed a large lesion in the pyramidal part of the right temporal bone as an expansile osteolytic mass. Cranial magnetic resonance imaging (MRI) revealed that the lesion was isointense on T 1 and T 2 -weighted images compared with the brain parenchyma. In addition, the lesion was markedly enhanced with gadopentatate dimeglumine, suggesting malignancy of unknown origin (Fig. 1b). Because of poor hepatic reserve, it was difficult to perform surgery. Instead, the right temporal bone was irradiated with a total dose of 50 Gy. Although little improvement in facial paresis was noted, the patient reported marked pain relief.Three months later, the patient developed refractory ascites with poor general condition. Surprisingly, CT showed a well-enhanced large tumor around the medial part of the liver, suggesting a large HCC (Fig. 1c).Tumor markers were elevated with AFP of 580 ng/mL and PIVKA-II of 287 mAU/mL. Hepatectomy was ruled out because of poor hepatic reserve and rapid tumor progression. Two weeks later, the patient died due to deterioration of his general condition. Autopsy showed massive HCC with tumor thrombosis in the right portal trunk and small metastatic nodules throughout the liver. A tumor in the pyramidal part of the right temporal bone was identified, ...

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supporting

confidence: 53%

Fibrolamellar Carcinoma of the Liver in a Japanese Hepatitis B Virus Carrier

Morise¹,

Sugioka²,

Mizoguchi

et al. 2005

J of Gastro and Hepatol

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“…Based on the SEER database, there appears to be a racial/ethnic predilection for Caucasians [47]. However, FLC has been reported from a wide variety of geographical locations including Mexico [53], Saudi Arabia [33], South Africa [54, 55], Japan [56], Taiwan [57, 58], Mainland China [59], Republic of Korea [60], Thailand [32], India [28, 61], and Europe [62], and the extent of the racial/ethnic bias remains poorly defined.…”

Section: Clinical Findingsmentioning

confidence: 99%

“…FLCs do not generally arise in the setting of any known chronic liver disease: the background livers typically lack significant inflammation or fibrosis [68]. While occasional reports have described the presence of hepatitis B viral proteins or DNA in FLC [2, 61, 107, 108], this appears to be by chance given the high worldwide prevalence of chronic hepatitis B infection and there is no data to suggest hepatitis B as an etiological agent. Likewise, FLCs have also developed in women using oral contraceptive pills [53, 109], but the association again appears to be by chance.…”

Section: Etiologymentioning

confidence: 99%

Fibrolamellar Carcinoma: 2012 Update

Torbenson

2012

Scientifica

146

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Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tumor cells have prominent nucleoli. The tumor cells induce the formation of extensive intratumoral fibrosis, which often grows in parallel, or lamellar bands. The tumor cells clearly show hepatocellular features but are also unique in showing both biliary and neuroendocrine differentiation. The uniqueness of fibrolamellar carcinoma extends to their molecular findings. While the genetic abnormalities that lead to fibrolamellar carcinomas are not yet known, studies have shown that they lack mutations in the genes most commonly mutated in typical hepatocellular carcinoma (TP53 and CTNNB1). In this paper, the clinical, pathological, and basic science literature on fibrolamellar carcinoma is comprehensively reviewed. Key areas of needed research are also discussed.

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“…However, because the data was registry-based, the authors were not able to identify any risk factors. 203 Although some recent case reports have identified the hepatitis B core antigen within the tumor tissue in cases of FLC, 205 it is not commonly associated with any of the traditional risk factors for HCC including hepatitis B and hepatitis C infections. 5,201 There have also been reports of FLC arising from a previous focal nodular hyperplasia.…”

Section: Other Primary Liver Cancersmentioning

confidence: 99%

Epidemiology of Primary and Secondary Liver Cancers

Ananthakrishnan

Gogineni

Saeian

2006

Semin intervent Radiol

161

107

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Primary liver cancer is the sixth most common cancer worldwide with a wide geographic distribution. The incidence of primary liver cancer is increasing and there is still a higher prevalence in developing countries. Early recognition remains an obstacle and lack of it results in poor outcomes for hepatocellular carcinoma (HCC), the most prevalent primary liver cancer, and cholangiocarcinoma. The most common risk factors associated with HCC are hepatitis B and chronic hepatitis C infections, alcohol use, smoking, and aflatoxin exposure. Emerging risk factors such as obesity might play an important role in the future because of the increasing prevalence of this condition.

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The detection of HBV antigens and HBx‐transcripts in an Indian fibrolamellar carcinoma patient: a case study

Cited by 15 publications

References 16 publications

Fibrolamellar Carcinoma of the Liver in a Japanese Hepatitis B Virus Carrier

Fibrolamellar Carcinoma of the Liver in a Japanese Hepatitis B Virus Carrier

Fibrolamellar Carcinoma: 2012 Update

Epidemiology of Primary and Secondary Liver Cancers

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