The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Abstract

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables the development of improved therapies.

Selective detection of peroxynitrite using an isatin receptor and a naphthalimide fluorophore

“…RAW 264.7 cells were incubated with lipopolysaccharide (LPS) which can promote inflammatory response and upregulate the concentration of ONOO − . 53–56 As shown in Fig. 2D, the fluorescence intensity of DSPE-PEG/HN-I exhibited a 1.5-fold increase for LPS-loaded RAW 264.7 cells.…”

A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Drug-Induced Liver Injury Mice

“…Compared to traditional methods, fluorescence-based techniques − have attracted great attention for ONOO – detection and imaging due to their high sensitivity, the ability to monitor analytes in real time, and noninvasiveness. − However, many fluorescent probes for ONOO – developed are small in Stokes shift, resulting in a high fluorescence inner filter effect and low fluorescence contrast. , Furthermore, the sensing mechanisms of the probes developed for ONOO – are generally based on the strong oxidative property of ONOO – ; this causes other reactive species to easily interfere with the sensing. , Finally, the emission wavelength of many of the ONOO – fluorescent probes reported is in the visible region, compromising the in vivo diagnostic potential for DILI. , …”

Human serum albumin-based supramolecular host–guest boronate probe for enhanced peroxynitrite sensing

“…14,15 The development of fluorescent probes for ONOO − sensing has proven to be effective to help improve our understanding of its intrinsic roles in complicated biological systems. 16,17 The probes developed have achieved the visualization of ONOO − in living cells and tissues, allowing researchers to study ONOO − relevant biological events in real-time. 18 They can also be used to quantify ONOO − levels in biological samples, thus facilitating the diagnosis of diseases associated with ONOO − .…”