Human serum albumin-based supramolecular host–guest boronate probe for enhanced peroxynitrite sensing

藤田, 和也; Guo, Cheng; Hu, Xi‐Le; Wang, J.‐J.; Zang, Yi; James, Tony D.; Li, Jia; He, Xiao‐Peng

doi:10.1039/d3ob00637a

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob00637a

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Human serum albumin-based supramolecular host–guest boronate probe for enhanced peroxynitrite sensing

和也藤田

Cheng Guo

Xi‐Le Hu

et al.

Abstract: Host–guest inclusion of a small-molecule fluorescent probe into human serum albumin enhances its sensitivity for ONOO− in aqueous solution and in cells.

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2024

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Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Cabello,

Chen,

Melville

et al. 2024

Chem. Rev.

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Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the airoxygen and nitrogen. They are produced in biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced to prevent indiscriminate damage to biological molecules. Small molecule probes can transmute the specific nature of each reactive oxygen and nitrogen species into an observable luminescent signal (or even an acoustic wave) to offer sensitive and selective imaging in living cells and whole animals. This review focuses specifically on small molecule probes for superoxide, hydrogen peroxide, hypochlorite, nitric oxide, and peroxynitrite that provide a luminescent or photoacoustic signal. Important background information on general photophysical phenomena, common probe designs, mechanisms, and imaging modalities will be provided, and then, probes for each analyte will be thoroughly evaluated. A discussion of the successes of the field will be presented, followed by recommendations for improvement and a future outlook of emerging trends. Our objectives are to provide an informative, useful, and thorough field guide to small molecule probes for reactive oxygen and nitrogen species as well as important context to compare the ecosystem of chemistries and molecular scaffolds that has manifested within the field.

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Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Cabello,

Chen,

Melville

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

show abstract

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Human serum albumin-based supramolecular host–guest boronate probe for enhanced peroxynitrite sensing

Abstract: Host–guest inclusion of a small-molecule fluorescent probe into human serum albumin enhances its sensitivity for ONOO− in aqueous solution and in cells.

Cited by 1 publication

References 38 publications

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

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