The Design of Chemical Experiments

Read, D. R.

doi:10.2307/3001662

Cited by 9 publications

(9 citation statements)

References 1 publication

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“…The signed social networks analyzed in this work are (i) Gama, a set of political alliances and oppositions among the Gahuku-Gama subtribes in the highland New Guinea [28,29], (ii) WWI, networks of relations among the major players in the First World War at different times [7], (iii) Epinions, a trust-distrust network among users of the product review site Epinions [30], (iv) Slashdot, a friend-foe network in the technological news site Slashdot [9,31], and (v) WikiElections, a network representing the votes for the election of administrators in Wikipedia [32]. Network (i) was downloaded from UCINET IV Datasets at in [33], (ii) was built from the information provided by Antal et al [7], and (iii)-(v) were downloaded from the Stanford Network Analysis Platform [34].…”

Section: A Data Setsmentioning

confidence: 99%

“…The first deals with the evolution of the relations among the major players in World War I (WWI) [7]. The second is provided by the Gahuku-Gama subtribe system of the Eastern Central Highlands of New Guinea [28,29]. In Fig.…”

Section: Balance In Small Social Networkmentioning

confidence: 99%

“…The signed network of the Gahuku-Gama subtribe system of the Eastern Central Highlands of New Guinea describes a series of alliances and oppositions among the Gahuku-Gama subtribes [28,29], which are distributed in a particular area and engage in prolonged warfare. In fact, "[warfare] .…”

Section: Balance In Small Social Networkmentioning

confidence: 99%

“…(Color online) Lack of global and local balance among the subtribes in the highlands of New Guinea. Subtribes are represented by circles with radii proportional to their degree of balance and located on an artistic representation of New Guinea highlands according to Read[29]. Solid dark blue lines are for alliance (Rova) relations and red dashed lines are for antagonistic (Hina) relations.…”

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confidence: 99%

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Walk-based measure of balance in signed networks: Detecting lack of balance in social networks

2014

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There is a longstanding belief that in social networks with simultaneous friendly and hostile interactions (signed networks) there is a general tendency to a global balance. Balance represents a state of the network with a lack of contentious situations. Here we introduce a method to quantify the degree of balance of any signed (social) network. It accounts for the contribution of all signed cycles in the network and gives, in agreement with empirical evidence, more weight to the shorter cycles than to the longer ones. We found that, contrary to what is generally believed, many signed social networks, in particular very large directed online social networks, are in general very poorly balanced. We also show that unbalanced states can be changed by tuning the weights of the social interactions among the agents in the network.

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Section: A Data Setsmentioning

confidence: 99%

Section: Balance In Small Social Networkmentioning

confidence: 99%

Section: Balance In Small Social Networkmentioning

confidence: 99%

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confidence: 99%

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Walk-based measure of balance in signed networks: Detecting lack of balance in social networks

2014

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“…16 It is, however, rather inefficient and unreliable. [17][18][19] The same applies to the trial-and-error method, especially in a complex environment. 20 Also, either method obviously provides poor means to explain parameter interactions and are aimed toward ending up at the optimum proper rather than providing predictive power.…”

Section: Introductionmentioning

confidence: 99%

Parameter Refinement for Molecular Docking

Salo

Yliniemelä

Taskinen

1998

J. Chem. Inf. Comput. Sci.

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Finding the optimal parameter values for any computer program with adjustable parameters can be very time consuming. In this paper, we introduce the use of the Plackett-Burman and the central composite designs with the aid of the partial least squares method to tackle this problem. Using DOCK3.5 as a test case, we also show a four-step procedure for sequential docking utilizing two parameter sets, both effecting a different level of accuracy. The DOCK parameter values were refined for protein kinase C regulatory domain yielding an orientation at the global "energy" minimum, which is in very good agreement with the experimental protein kinase C regulatory domain-phorbol 13-acetate complex. The scheme is now being used for screening molecular databases to find putative protein kinase C inhibitors.

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The effect of fermentation parameters on the production of Mucor miehei acid protease in a chemically defined medium

Ayhan

Çelebi

Tanyolaç

2001

J of Chemical Tech & Biotech

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Batch shake flask experiments were carried out with a fungal strain of Mucor miehei ATCC 3420 to study the effects of five fermentation parameters; initial D‐glucose concentration, temperature, initial pH, agitation rate and inoculum ratio, on the production of rennin in a chemically defined medium. A statistical design was used to assign the experimental levels of five fermentation parameters for the determination of optimum conditions. The highest concentration of milk‐clotting activity (MCA) obtained was 2286 SU cm−3 (without concentration of the broth) at 29.6 g dm−3 initial D‐glucose concentration, 6.8 initial pH, 37.6 °C temperature, 81 stroke per min agitation rate and 5.2% (v/v) inoculum ratio. Although enzyme secretion was a function of all the operational parameters investigated, the pH range (4.6–5.2) reached at the time of enzyme production had a profound effect on milk‐clotting activity levels. In the fermentation sample at maximum milk‐clotting activity the R factor, the ratio of milk‐clotting activity to proteolytic activity, was determined as 1 SU PU−1, denoting similar characteristics to a commercial animal rennet.© 2001 Society of Chemical Industry

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The Design of Chemical Experiments

Cited by 9 publications

References 1 publication

Walk-based measure of balance in signed networks: Detecting lack of balance in social networks

Walk-based measure of balance in signed networks: Detecting lack of balance in social networks

Parameter Refinement for Molecular Docking

The effect of fermentation parameters on the production of Mucor miehei acid protease in a chemically defined medium

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