The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients�

Zhao, Xiubao; Li, Xu; Ma, Ying; Zhu, Yulan

doi:10.3892/etm.2019.7833

Cited by 2 publications

(2 citation statements)

References 17 publications

(19 reference statements)

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“…The results of this study show that hs-CRP level increases, indicating that the risk for AR development increases when inflammation deteriorates [13] . In addition to its important role in the regulation of thrombosis, platelets are also important amplification factor of human inflammatory response [14] . Platelet activation will lead to the release of a large number of inflammatory mediators, and induce the expression of inflammatory mediators in macrophages, monocytes and granulocytes.…”

Section: Discussionmentioning

confidence: 99%

Study on Related Factors of Aspirin Resistance in Acute Ischemic Stroke

Shi

Ding

Geng

2022

JCNR

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Objective: To study the related factors of aspirin resistance (AR) in acute ischemic stroke. Methods: A total of 138 patients with acute ischemic stroke treated in hospital affiliated to Xuzhou medical university from August 2016 to August 2018 were the study subjects, examine his medical data from the past. They were divided into the AR group (40 cases) and the non-AR group (98 cases) according to whether AR appears. Gender, disease history, biochemical indicators and etc. were compared between the two groups. The independent risk factors of AR were investigated using univariate analysis and logistic regression analysis. Results: 40 cases of AR occurred in 138 patients, with an incidence rate of 28.99%. Diabetes, platelet count (PLT), microRNA-19a (m iR-19a) expression, smoking, high-sensitivity C-reactive protein (hs-CRP), Low-density lipoprotein cholesterol (LDL-C), fibrinogen (FIB) and age difference between the AR group and non-AR group was statistically significant (P<0.05). Gender, hypertension, uric acid (UA), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), homocysteine (Hcy), total cholesterol (TC), and alanine aminotransferase (ALT) between the two groups were not significantly different (P>0.05). Logistic regression analysis showed that the independent risk factors for AR in acute ischemic stroke were diabetes (OR=2.773, 95%CI: 1.102~5.065, P=0.025), miR-19a (OR=3.021, 95%CI: 1.322~6.545, P=0.021), hs-CRP (OR=2.719, 95%CI: 1.301~5.022, P=0.028) and smoking (OR=1.983, 95%CI: 1.114~3.887, P=0.040). Conclusion: The incidence of AR is higher in acute ischemic stroke. Risk factors include diabetes, miR-19a expression, hs-CRP, smoking, etc. Clinical intervention measures can be taken to reduce the risk of AR and improve acute ischemic stroke prognosis.

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Section: Discussionmentioning

confidence: 99%

Study on Related Factors of Aspirin Resistance in Acute Ischemic Stroke

Shi

Ding

Geng

2022

JCNR

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“…The challenge of population aging is becoming increasingly intense in several developed and developing countries, such as China, Japan, and the United States (Zhao et al, 2019). An Italian study showed that about 40% of more than 3,000 people over 60 years old had gastrointestinal symptoms due to the presence of disordered digestive function in the elderly population (Pilotto et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Focusing on Helicobacter pylori infection in the elderly

Gong

Xu²,

Zhang³

2023

Front. Cell. Infect. Microbiol.

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As a confirmed carcinogen, Helicobacter pylori (H. pylori) is the main cause of inflammatory diseases of the upper digestive tract and even gastric cancer. There is a high prevalence of H. pylori infection among the elderly population, which may cause adverse clinical outcomes. Particularly noteworthy is that guidelines or expert consensus presently available on H. pylori infection overlook the management of the elderly population as a special group. A brief overview of H. pylori in the elderly is as follows. The detection of H. pylori infection can be divided into invasive and non-invasive techniques, and each technique has its advantages and shortcomings. There may be more side effects associated with eradication treatment in elderly individuals, especially for the frail population. Physical conditions and risk-benefit assessments of the elderly should be considered when selecting therapeutic strategies for H. pylori eradication. Unless there are competing factors, elderly patients should receive H. pylori eradication regimens to finally reduce the formation of gastric cancer. In this review, we summarize the latest understanding of H. pylori in the elderly population to provide effective managements and treatment measures.

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The design of a homocysteine fluorescent probe based on Rhodamine B and its responsiveness in the serum of cerebral infarction patients�

Cited by 2 publications

References 17 publications

Study on Related Factors of Aspirin Resistance in Acute Ischemic Stroke

Study on Related Factors of Aspirin Resistance in Acute Ischemic Stroke

Focusing on Helicobacter pylori infection in the elderly

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