The design and biomedical applications of self-assembled two-dimensional organic biomaterials

Zhang, Xiaoyuan; Gong, Coucong; Akakuru, Ozioma Udochukwu; Su, Zhiqiang; Wu, Aiguo; Wei, Gang

doi:10.1039/c8cs01003j

Cited by 117 publications

(68 citation statements)

References 227 publications

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“…On the other hand, among the organs of CaP-MA-40 group, the descending sequence of MI was: testis (8055, 8408), liver (6611), brain (5253), kidney (4268, 4407), lung . Surprisingly, the MI of testis was strongest among the organs and it was also universally acknowledged that the bio-distributions were associated with the potential application such as organs imaging and targeting [41][42][43]. Furthermore, the GFP expression of different organs were also observed by laser scanning confocal microscopy (Fig.…”

Section: In Vivo Transgene Experimentsmentioning

confidence: 92%

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors

Jia

et al. 2020

J Nanobiotechnol

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Background: Gene therapy remains a significant challenge due to lots of barriers limiting the genetic manipulation technologies. As for non-viral delivery vectors, they often suffer insufficient performance due to inadequate cellular uptake and gene degradation in endosome or lysosome. The importance of overcoming these conserved intracellular barriers is increasing as the delivery of genetic cargo. Results: A surface-functionalized non-viral vector involving the biomimetic mannitol moiety is initiated, which can control the cellular uptake and promote the caveolae-mediated pathway and intracellular trafficking, thus avoiding acidic and enzymatic lysosomal degradation of loaded gene internalized by clathrin-mediated pathway. Different degrees of mannitol moiety are anchored onto the surface of the nanoparticles to form bio-inspired non-viral vectors and CaP-MA-40 exhibits remarkably high stability, negligible toxicity, and significantly enhanced transgene expression both in vitro and in vivo. Conclusions: This strategy highlights a paradigmatic approach to construct vectors that need precise intracellular delivery for innovative applications.

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Section: In Vivo Transgene Experimentsmentioning

confidence: 92%

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors

Jia

et al. 2020

J Nanobiotechnol

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“…Graphene, another atomic layer of carbon having better chemical stability [11][12][13][14], has good charge transfer properties than semiconducting MoS 2 , and it has been used widely for selective detection of biomolecules in its modified state [15,16]. Poor response of a sensor signal due to thermal fluctuations and defects in the sensing platform can be evaded by interfacing it with a low electronic noise system such as graphene [17].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Molybdenum disulfide–graphene van der Waals heterostructures as stable and sensitive electrochemical sensing platforms

et al. 2020

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Atomic layers are sought after for molecular sensing due to their available high surface interaction area, and different types of monolayers are attempted for sensing in the recent past. However, their chemical stability towards these molecules is questioned in recent times and alternate methods need to be developed to circumvent such issues, while maintaining high sensitivity. Here, the van der Waals (vdWs) stacks of molybdenum disulfide (MoS 2) and graphene are shown for their stable electrochemical sensing towards ascorbic acid (AA) and dopamine (DA)-two important biomolecules. AA is known to chemically react with MoS 2 leading to unstable sensing platform, while here the graphene coverage is shown to protect the MoS 2 even from low-energy plasma exposure while keeping the same high sensitivity. Upon proving the graphene-based protection of the sensor, such a sensing platform is shown for its applicability in DA sensing, where it is found to give a linear response in a wide range of concentrations (2.5 to 600 µmol•L −1) and even selective sensing in the presence of AA. Such a stack is found to be not merely giving protection to the beneath MoS 2 layer but also the inter-layer charge transfer due to work function differences being beneficial in bringing fast and high sensitivity to the next-generation sensors and point-of-care devices.

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“…Covalent binding of PEG to GO has been widely used to improve the stability and long circulation of GO with high drug-loading capacity [13,14]. GO modified by antibodies or peptides or other bioactive molecules could achieve targeted delivery [15][16][17]. Though GO-based nanocarriers feature a number of advantages over other nanocarriers, they are restricted by their poor drug-release capacity.…”

Section: Introductionmentioning

confidence: 99%

Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nanoparticles for castration-resistant prostate cancer therapy

et al. 2020

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Background: Enzalutamide (Enz) has shown limited bioavailability via oral administration. Castration-resistant prostate cancer (CRPC) is frequent among patients receiving 18-24 months of androgen deprivation therapy. The nonsteroidal anti-androgen enzalutamide (Enz) used in the treatment of prostate cancer has shown limited bioavailability via oral administration. Therefore, we developed a multifunctional enzalutamide-loaded graphene oxide nanosystem (TP-GQDss/Enz) for CRPC intravenous treatment, with high drug loading efficiency. Methods: Aminated graphene quantum dots (GQDs) were first cross-linked via disulfide bonds into a graphene quantum dot derivative of approximately 200 nm (GQDss), which was further functionalized with a tumour-targeting peptide and PEG to form TP-GQDss. Enz was loaded into TP-GQDss for in vitro and in vivo study. Results: The results showed that high drug-loading efficiency was achieved by TP-GQDss via π-π electron interaction. TP-GQDss could be rapidly internalized by CRPC cells via endocytosis. Moreover, Enz in TP-GQDss could inhibit the growth of C4-2B and LNCaP prostate cancer cell lines in vitro. Further, TP-GQDss exhibited an enhanced cancertargeting ability and alleviated the side effects of Enz in vivo. Conclusions: The multifunctional nanocarrier constructed here could accomplish controlled Enz release and serve as an intravenous therapy platform for CRPC.

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The design and biomedical applications of self-assembled two-dimensional organic biomaterials

Abstract: Self-assembling 2D organic biomaterials exhibit versatile abilities for structural and functional tailoring, as well as high potential for biomedical applications.

Cited by 117 publications

References 227 publications

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors

Molybdenum disulfide–graphene van der Waals heterostructures as stable and sensitive electrochemical sensing platforms

Intravenous delivery of enzalutamide based on high drug loading multifunctional graphene oxide nanoparticles for castration-resistant prostate cancer therapy

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