The Dermo-Epidermal Junction in Bullous Pemphigoid

Kobayasi, T

doi:10.1159/000254252

Cited by 43 publications

(14 citation statements)

References 3 publications

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“…within the lamina lucida [8][9][10][11][12]. Ultrastructural changes of the early nonbullous erythema have not been fully described apart from discontinuities of the basal lamina and an enlarged lamina lucida [10][11][12], Although we have not elinically studied vesiculated skin in this case, the electron microscopic findings of early ery thematous changes in the skin showed small vacuoles and lacunae along the uppermost portion of the dermis.…”

Section: Discussionmentioning

confidence: 88%

Vesicular Pemphigoid – Ultrastructural and Immunoelectron Microscopic Study

Hayakawa

Shimizu²,

Amagai³

et al. 1989

Dermatology

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We report a patient with vesicular pemphigoid who showed clinically numerous small vesicles and figurate erythema over the trunk and extremities. Although large blisters were absent, immunofluorescent study revealed IgG and C3 deposition at the basement membrane zone of the lesional skin. The patient responded well to the combined use of corticosteroid and dapsone. Immunoelectron microscopy showed IgG and C3 deposition at the undersurface membrane of the basal cells and the lamina lucida. Electron microscopy of the nonvesiculated early erythematous skin showed small vacuoles and lacunae along the uppermost portion of the dermis. Although the clinical features of this patient and the good therapeutic response to dapsone were atypical, the results of immunopathology and immunoelectron microscopy were consistent with typical pemphigoid.

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Section: Discussionmentioning

confidence: 88%

Vesicular Pemphigoid – Ultrastructural and Immunoelectron Microscopic Study

Hayakawa

Shimizu²,

Amagai³

et al. 1989

Dermatology

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“…Moreover, the PAS reaction, which is also positive for phospholipids [27], has been shown to cover an area analogous to the zona diffusa [9], and may account for the separation achieved in this zone with the phospholipase-C enzyme. Thus, it appears that upon secretion of procollagen from the cells, these soluble precursor molecules, after cleavage at their amino-terminal ends, may become coated with various ground substances inducing polymerisation into chains of variable thickness [28].…”

Section: Discussionmentioning

confidence: 94%

“…Anchoring fibers and filaments, surmised to be elastin, were suggested to be responsible for bind ing the epidermis to the dermis [8,9], Finally, from the ability of inducing subepidermal suction-pressure blisters [10], an oily-viscous compound was claimed to be lodged at the dermo-epidermal junction which could be involved in dermal-epidermal concretion [11],…”

Section: Introductionmentioning

confidence: 99%

Mode of Dermal-Epidermal Adhesion

Omar¹,

Krebs²

1975

Dermatology

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“…There is a sparse dermal inflammatory eell infiltrate in lesions present on normal-appearing skin (-35), but a dense inflammatory eell infiltrate in the dertnis of lesions on an erythematous base (36). The findings on electron mieroseopy of the infiltrate-rieh and infiltrate-poor lesions are different (37). In the infiltrate-poor lesion, the bullae are formed in the lamina lucida whieh is followed by the separation of the basal eell from the basal lamina due to tearing.…”

Section: Bullous Pemphigoid (Bp)mentioning

confidence: 97%

Diagnosis of bullous disease and studies in the pathogenesis of blister formation using immunopathological techniques

Ahmed

1984

J Cutan Pathol

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Several skin diseases may present as vesicles or bullae. Immunofluorescent studies arc very helpful in differentiating the various disea.sc entities. Familiarity with the procedure and the various kinds of patterns that are specific and non-specific is essential for the practicing dermatologist. Immunofluorescent patterns are particularly helpful in differentiating pemphigus, bullous pemphigoid. cicatrical pcmphigoid. herpes gcstaliottis, dertttatitis hetpetifortttis, linear IgA derniatosis and porphyria. ImniunofluorcscenI studies of the skin and sera of these patients were vital to an understanding their pathogenesis. Immunoelcetron microscopy has further helped in delineating the exact sites of immunoglobulin deposition, and. thus, identifying the location of the antigens. In pemphigus, studies at the molecular level reveal thai the basic pathological process is mediated by an anti-cellular cement substance antibody. The binding of this antibody at the cell surface level results in a process Ihal is seen at the lighl microscopy level in the form of acantholysis. In bullous pcmphigoid cells may play an important role, tt appears ihat the mast cell, cosinophil. and the lymphocyte in harmony with the polymorplioiiuclcar leucocyte work together to bring about an enzymatic degradation of Ihc basement membrane. The specilic role of the anti-basement membrane zone antibody is also under current study. With advances in molecular immunology, especially monoclonal antibodies and gene technology, it is hoped that these cellular and molecular interactions will be better understood and further defined. February 21, 1984 In this review. I shall bnefly outline the pnn-"..,"" . Accepted for ptthlication, Principles of fluorescent niicro.scopv ciples of lmmunofluorescence microscopy and use of tbis technique in the diagito.sis of bull-The knowledge, understanding and interous disease. The role of immunopathology in pietalion of ctitaneous immttnonttorescence the advancement of understanding the patho-arc no longer eonfined to tfte histopathologist genesis of blister formation will then be dis-or lo the realms of research, but it is a procussed in detail.eedure thai should be tinderstood by the piae-16 Cutaneous P;t(hoi<)gy il; 4

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The Dermo-Epidermal Junction in Bullous Pemphigoid

Cited by 43 publications

References 3 publications

Vesicular Pemphigoid – Ultrastructural and Immunoelectron Microscopic Study

Vesicular Pemphigoid – Ultrastructural and Immunoelectron Microscopic Study

Mode of Dermal-Epidermal Adhesion

Diagnosis of bullous disease and studies in the pathogenesis of blister formation using immunopathological techniques

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