The dental plaque biofilm matrix

Jakubovics, Nicholas S.; Goodman, Steven D.; Mashburn‐Warren, Lauren; Stafford, Graham P.; Cieplik, Fabian

doi:10.1111/prd.12361

Cited by 174 publications

(155 citation statements)

References 346 publications

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“…The major constituents of EPS include polysaccharides, proteins, DNAs, lipids, and other polymeric compounds, and are dependent on bacterial species and environmental conditions. The EPS matrix also contains considerable amounts of proteins that are critical for adhesion and colonization, such as enzymes and protein structures like pili and fimbriae [ 8 , 10 ]. Microbial surface proteins can be generally divided into two groups: functional surface proteins like adhesins, and long-chain surface-bound macromolecules like pili [ 40 ].…”

Section: How Does the Process Of Surface Adhesion Occur?mentioning

confidence: 99%

“…Gram-negative oral bacteria produce a variety of adhesins that contribute to both polymicrobial biofilm formation and host cell interactions. For example, long (FimA) and short (MfaI) pili of P. gingivalis are involved in host cell coaggregation and adhesion [ 8 ].…”

Section: Development Of Biofilmmentioning

confidence: 99%

“…It is an optional Gram-positive anaerobic [ 4 ], which uses a wide range of carbohydrate sources for survival [ 21 ] and is abundant in supragingival and subgingival plaque [ 21 ]. It is usually reported as non-motile, although S. sanguinis produces short type IV pili that do not confer motility but are important for adhesion to host cells [ 8 ].…”

Section: Development Of Biofilmmentioning

confidence: 99%

“…Biofilms consist of sessile bacterial communities protected by a self-produced polymer matrix that may contain proteins, carbohydrates, nucleic acids, and molecules [ 3 , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. Communities are formed by varied interactions between species and genera, which include physical cell-cell associations, known as coaggregation, interspecies signaling, secretion and renewal of antimicrobial compounds, and sharing of an extracellular matrix [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main components are polysaccharides, proteins, nucleic acids, and lipids, interacting within each other to constitute an aqueous gel-like material with proper mechanical properties and resistance to external shocks [ 23 ]. And yet, in more mature biofilms, the matrix provides physicochemical forces for biofilm adhesion to the substrate [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Bacterial adhesion to biomaterials: What regulates this attachment? A review

Kreve

Reis

2021

Japanese Dental Science Review

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Highlights Bacterial adhesion to the surface of dental materials play a significant role in infections. The factors that govern microbial attachment involves different types of physical-chemical interactions and biological processes. Studying bacterial adhesion makes it possible to understand the mechanisms involved in attachment and helps in the search for technologies that promote antibacterial surfaces.

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Section: How Does the Process Of Surface Adhesion Occur?mentioning

confidence: 99%

Section: Development Of Biofilmmentioning

confidence: 99%

Section: Development Of Biofilmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Kreve

Reis

2021

Japanese Dental Science Review

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Pathology‐Guided Cell Membrane‐Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

Pan,

Zhong,

Lan

et al. 2024

Adv Funct Materials

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Nanodrug delivery systems (NDDSs) for the treatment of periodontitis remain a significant clinical challenge. The low biocompatibility, singular effect, and lack of disease specificity of conventional nanoparticles limit their biomedical application. Recent studies have highlighted the pivotal role of cell membrane‐coated nanotechnology in anti‐inflammatory strategies due to its improved biocompatibility and superior biointerface properties. Herein, combined with the pathological heterogeneity of periodontitis revealed by bioinformatics analysis, this study develops a novel cell membrane‐coated nanoparticle composed of two elements: minocycline‐loaded polydopamine nanoparticles (PM) and cRGD‐modified cell membrane (RCM). The in vitro results indicate that PM@RCM rescues impaired human periodontal ligament stem cells through antioxidant, anti‐ferroptosis, anti‐inflammatory, and pro‐osteogenic effects, and exhibits favorable antibacterial bioactivity. The in vivo studies further reveal that PM@RCM promotes periodontal tissue regeneration and remodeled periodontal homeostasis in periodontitis mice. Collectively, these findings highlight the unique pathological changes in periodontitis. Moreover, the novel NDDS developed in this study, which leverages the excellent natural properties of cell membrane‐coated nanotechnology and the versatility of nanoparticle cores, provides a promising strategy for the clinical treatment of periodontitis.

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Effect of the zinc transporter ZupT on the virulence mechanisms of mesophilic Aeromonas salmonicida SRW‐OG1

Wang

Huang

2023

Animal Research and One Health

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As a typical psychrophilic bacterial pathogen, Aeromonas salmonicida causes furunculosis in wild and farmed freshwater and marine fish, leading to substantial economic losses in the global aquaculture industry. Previous studies have shown that A. salmonicida is unable to grow above 25°C, hence limiting its infection to cold‐water fish. However, we isolated A. salmonicida SRW‐OG1, a mesophilic pathogenic strain from the warm‐water fish Epinephelus coioides. Through RNA‐seq analysis, we observe significant upregulation of the zupT gene at 28°C. ZupT is a member of zinc‐regulated transporters and iron‐regulated transporter‐like proteins (ZIP family) and is closely associated with transcriptional regulation of virulence in certain pathogens. Consequently, our study aimed to examine the role of zupT during A. salmonicida SRW‐OG1 infection at high temperatures. Our findings demonstrate that the zupT‐RNAi strain exhibits severe growth restriction under limited Zn2+ and Fe2+ conditions. Notably, this strain shows significantly reduced mortality rates and colonization abilities. Moreover, its motility, biofilm formation, adhesion, and hemolytic activities are significantly diminished. Confocal laser scanning microscopy reveals earlier and accelerated biofilm dissociation in the zupT‐RNAi strain. Analysis of extracellular products at 36 h indicates a considerable reduction in relative extracellular protein content in the zupT‐RNAi strain. Taken together, our results highlight the vital role of the zupT gene in zinc transport and the fitness of A. salmonicida SRW‐OG1 within the host.

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The dental plaque biofilm matrix

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 174 publications

References 346 publications

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Bacterial adhesion to biomaterials: What regulates this attachment? A review

Pathology‐Guided Cell Membrane‐Coated Polydopamine Nanoparticles for Efficient Multisynergistic Treatment of Periodontitis

Effect of the zinc transporter ZupT on the virulence mechanisms of mesophilic Aeromonas salmonicida SRW‐OG1

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