The decrease of some serum free amino acids can predict breast cancer diagnosis and progression

Eniu, Dan Tudor; Romanciuc, Florina; Moraru, Corina; Goidescu, Iulian; Staicu, Adelina; Răchieriu, Claudiu; Buiga, Rareș; Socaciu, Carmen

doi:10.1080/00365513.2018.1542541

Cited by 33 publications

(46 citation statements)

References 38 publications

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“…Targeted and untargeted metabolomics both accounted for 6 articles ( Figure 5C). [15,27], plasma [17], tissue [18], saliva [42], urine [46] 6 plasma [9,34,41], serum [14,18,23] 2 Alanine 6 saliva [11,42], serum [15], plasma [21,41], urine [43] 5 plasma [9,34], serum [14], urine [22], serum&plasma [30] 3 Glutamic acid 6 serum [15], tissue [16,18], plasma [21], saliva [17,42] 4 plasma [9], serum [14], urine [22], serum&plasma[32] 4…”

Section: Study Characteristicsmentioning

confidence: 99%

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Application of metabolomics in the diagnosis of breast cancer: a systematic review

Yang¹,

Wang²,

Cai³

et al. 2020

J. Cancer

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Breast cancer (BC) remains the most frequent type of cancer in females worldwide. However, the pathogenesis of BC is still under the cloud, along with the huge challenge of early diagnosis, which is widely acknowledged as the key to a successful therapy. Metabolomics, a newborn innovative technique in recent years, has demonstrated great potential in cancer-related researches. The aim of this review is to look back on clinical and cellular metabolomic studies in the diagnosis of BC over the past decade, and provide a systematic summary of metabolic biomarkers and pathways related to BC diagnosis.

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Section: Study Characteristicsmentioning

confidence: 99%

“…Valine 4 saliva [11,42], serum [15], plasma [21] 6 plasma [9,17,24,34], serum [14], urine[22] 5 Phenylalanine 5 serum [15], tissue [18], saliva [26,42], urine […”

Section: Study Characteristicsmentioning

confidence: 99%

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Yang¹,

Wang²,

Cai³

et al. 2020

J. Cancer

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“…The importance of metabolite adaptations and profiling of metabolites in fine-needle aspiration biopsies, surgical biopsies, serum, urine and saliva was shown in various tumor types including breast, liver, thyroid and colorectal cancer (31)(32)(33)(34)(35)(36). However, it is important to note that metabolite profiling in nail materials of cancer patients, including breast cancer has not been reported in literature.…”

Section: Resultsmentioning

confidence: 99%

“…In this direction, several attempts are noticed by using metabolomic approaches, including LC-HRMS, GC-MS and NMR spectroscopy. These metabolomics approaches were focused on the tumor tissue and biological fluids, including serum, urine and saliva (30)(31)(32)(33)(34)(35)(36). However, literature completely lacks on the suitable methods that targets to profile nail metabolites of breast cancer and other tumor types.…”

Section: Introductionmentioning

confidence: 99%

Undetectable free aromatic amino acids in nails of breast carcinoma: Biomarkers discovery by a novel metabolite purification VTGE system

Mitruka

Gore

Kumar

et al. 2019

Preprint

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BACKGROUND: Metabolic reprogramming in breast cancer is depicted as a crucial change in the tumor microenvironment. Besides the molecular understanding of metabolic heterogeneity, appreciable attentions are drawn to characterize metabolite profiles in tumor tissue and derived biological fluids and tissue materials. Several findings reported on the metabolic alterations of free aromatic amino acids (FAAAs) and other metabolites in biological fluids. Furthermore, there is a significant gap in the development of a suitable method for the purification and analysis of metabolite biomarkers in nails of cancer patients. METHODS: To address the metabolite alterations specifically FAAAs level in nails, fingernail clippings of breast cancer patients (N=10), and healthy subjects (N-12) were used for extraction and purification of metabolites. Here, we report a novel and specifically designed vertical tube gel electrophoresis (VTGE) system that helped for the purification of metabolites in the range of (100-1000 Da) from nail materials. The claimed VTGE system uses 15% polyacrylamide under non-denaturing and non-reducing conditions that makes eluted metabolites directly compatible with LC-HRMS and other analytical techniques. Qualitative and quantitative determination of FAAAs in nail lysates were done by positive ESI mode of Agilent LC-HRMS platform. RESULTS: The analysis on collected data of nail metabolites clearly suggests that FAAAs including tryptophan, tyrosine, phenylalanine and histidine are undetectable in nail lysates of breast cancer over healthy subjects. This is a first report that shows the highly reduced levels of FAAAs in nails of breast cancer. Furthermore, present observation is in consonance with previous findings that support that breast cancer patients show cancer cachexia, high amino acid catabolism that drive metabolite driven cancer growth and proliferation. CONCLUSION: This paper provides a proof of concept for a novel and specifically developed VTGE process that assisted to show the first evidence on undetectable level of FAAAs in nails of breast cancer patients as metabolite biomarkers. Here, the authors propose the potential use of VTGE assisted process to achieve metabolomic discovery in nails of breast cancer and other tumor types.

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“…Monitoring treatment response and disease progression is primarily achieved using US and/or MRI. This follow up can be improved by using tumor markers such as CA15-3 [10] or blood serum free amino acid profiles, but the main disadvantage of the latter is that changes in the protein metabolism during pregnancy can cause misinterpretation of the results [48].…”

Section: Follow Up and Neoadjuvant Treatment Monitoringmentioning

confidence: 99%

The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer

et al. 2019

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Breast cancer diagnosed during pregnancy is at increasing incidence due to the increased frequency of obesity, the postponement of the first pregnancy to later decades of life and the advances of diagnostic techniques. Clinical and imaging diagnosis is difficult during gestation due to adaptive changes of the maternal organism , the mammary glads in particular. Furthermore, the therapeutic approach is limited both by the possible side effects on the fetus and by the skepticism of the couple over these therapeutic regimens.The present paper aims to review the main diagnostic steps to confirm pregnancy associated breast cancer, as well as the therapeutic possibilities during this period, related to the potential adverse effects concerning pregnancy

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The decrease of some serum free amino acids can predict breast cancer diagnosis and progression

Cited by 33 publications

References 38 publications

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Undetectable free aromatic amino acids in nails of breast carcinoma: Biomarkers discovery by a novel metabolite purification VTGE system

The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer

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