The Cytotoxicity of Metal Nanoparticles Depends on Their Synergistic Interactions

Abstract

This is the pre-peer reviewed version of the following article: The Cytotoxicity of Metal Nanoparticles Depends on Their Synergistic Interactions, which has been published in final form at doi.org/10.1002/ppsc.202000135. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."

The Analysis of Acute and Subacute Toxicity of Silver Selenide Nanoparticles Encapsulated in Arabinogalactan Polymer Matrix

“…Many researchers have shown that exposure to silver nanoparticles in low doses leads to the emergence and development of neurotoxic effects [ 7 , 8 , 9 , 11 , 40 , 41 , 42 ]. Skalska J. et al [ 40 ] described the development of pathological changes in neuronal mitochondria (edema, decreased potential of the mitochondrial membrane) and, as a consequence, the induction of autophagy of the neurons themselves when exposed to silver nanoparticles at a dose of 0.2 mg/kg.…”

“…Skalska J. et al [ 40 ] described the development of pathological changes in neuronal mitochondria (edema, decreased potential of the mitochondrial membrane) and, as a consequence, the induction of autophagy of the neurons themselves when exposed to silver nanoparticles at a dose of 0.2 mg/kg. The cytotoxic effect of low doses of silver nanoparticles on the main components of the blood–brain barrier (endothelial cells and astrocytes) was reported, as well as that directly on neurons, causing a disruption of the cell cytoskeleton and destruction of synaptic connections [ 7 , 41 ]. Our previous studies have shown that a silver nanocomposite encapsulated in an arabinogalactan polymer matrix, despite belonging to the IV low-hazard class of substances with LD 50 , when administered intragastrically at a dose of more than 5000 mg/kg of animal weight, disorders the structure of the nervous tissue, increases the area of mitochondria, violates the structure of nerve cells and activates the apoptosis process [ 43 ].…”

Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body

“…This in turn results in several cytotoxic effects: increased level of lipid peroxidase, inhibition of antioxidant activity, decrease in the potential of the mitochondrial membrane and activation of a The image is reprinted with permission from Ref. [190] pro-inflammatory response, damage of DNA and apoptosis [212] . Recently, Feng et al investigated the toxicity of IONPs (coated with either PEG or PEI-polyethylenimine) in-vitro and in-vivo [189].…”

“…Korzeniowska etal. studied the effect of co-exposure of silver and platinum NPs (possessing the same size and surface properties) on human brain cells such as immortalized cerebral microvascular endothelial cells (hCMEC/D3) and primary astrocytes [212] . Both types of cells form the blood-brain barrier (BBB) and function to protect the brain from toxins.…”

“…This in-turn can enhance permeability of the BBB. While this is commonly observed during an infection or injury in the brain and can help protect the brain through activation disassembly, extracellular matrix is important for maintaining tightness of BBB and its disassembly can negatively affect cell adhesion, migration and proliferation [212] . In a similar study, Guo et al studied the co-exposure of Fe 2 O 3 NPs and carbon black NPs on human lung epithelial cells in-vitro [214].…”