Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body

Senthilkumar, Neeharika; Sharma, Preetam K.; Sood, Neeru; Bhalla, Nikhil

doi:10.1016/j.ccr.2021.214082

Cited by 37 publications

(25 citation statements)

References 204 publications

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“…Under the perspective to ensure safety future in vivo applications, it is still mandatory to assess the MNPs’ time-dependent biodistribution and clearance [ 50 , 51 ]. In this way, our results for Ci-MnFe 2 O 4 MNPs distribution and clearance made it possible to observe a predominant retention profile in the liver and spleen.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry

et al. 2022

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Once administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity.

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Section: Discussionmentioning

confidence: 99%

Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry

et al. 2022

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“…By carefully selecting and tuning the synthetic procedure and adjusting its parameters, MNPs can be obtained practically with full control over their physicochemical properties (size, shape, composition, monodispersity, etc .). 132,133 This in turn can translate into improved magnetic properties, which are critical for magnetogenetic actuation, as described in section 2.2 of this review. These advances in the preparation of magnetic actuators with tailored properties provide exciting opportunities for the field, as is for instance the case of using a mixture of MNPs with different sizes, shapes and compositions, each one susceptible for activation by a different combination of AMF amplitude and frequency.…”

Section: Discussionmentioning

confidence: 98%

Magnetogenetics: remote activation of cellular functions triggered by magnetic switches

et al. 2022

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“…SPIONs have high saturation magnetisation and magnetic susceptibility, are chemically stable, biocompatible, biodegradable and non-toxic in nature. Iron oxide nanoparticles can be synthesised with ease and many different approaches have been reported, which include hydrothermal, solvothermal, sol-gel methods, co-precipitation, microwave-assisted, chemical vapour deposition, electrochemical, laser pyrolysis techniques and biosynthesis [ 16 , 17 ]. For biomedical applications, magnetic nanoparticles of iron oxide with the crystal structure of maghemite and magnetite are the most explored, and the temperature and pressure of the reaction conditions are mainly used to control the size and morphology of these MNPs.…”

Section: Magnetic Nanoparticles and Bone Tissue Engineeringmentioning

confidence: 99%

Magnetic Nanoparticles in Bone Tissue Engineering

2022

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Large bone defects with limited intrinsic regenerative potential represent a major surgical challenge and are associated with a high socio-economic burden and severe reduction in the quality of life. Tissue engineering approaches offer the possibility to induce new functional bone regeneration, with the biomimetic scaffold serving as a bridge to create a microenvironment that enables a regenerative niche at the site of damage. Magnetic nanoparticles have emerged as a potential tool in bone tissue engineering that leverages the inherent magnetism of magnetic nano particles in cellular microenvironments providing direction in enhancing the osteoinductive, osteoconductive and angiogenic properties in the design of scaffolds. There are conflicting opinions and reports on the role of MNPs on these scaffolds, such as the true role of magnetism, the application of external magnetic fields in combination with MNPs, remote delivery of biomechanical stimuli in-vivo and magnetically controlled cell retention or bioactive agent delivery in promoting osteogenesis and angiogenesis. In this review, we focus on the role of magnetic nanoparticles for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease. We highlight the materials-design pathway from implementation strategy through the selection of materials and fabrication methods to evaluation. We discuss the advances in this field and unmet needs, current challenges in the development of ideal materials for bone-tissue regeneration and emerging strategies in the field.

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Designing magnetic nanoparticles for in vivo applications and understanding their fate inside human body

Cited by 37 publications

References 204 publications

Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry

Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry

Magnetogenetics: remote activation of cellular functions triggered by magnetic switches

Magnetic Nanoparticles in Bone Tissue Engineering

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