The cytokine-hormone axis – the link between premenstrual syndrome and postpartum depression

Stoner, Rebecca; Camilleri, Victoria; Calleja‐Agius, Jean; Schembri-Wismayer, Pierre

doi:10.1080/09513590.2017.1318367

Cited by 17 publications

(14 citation statements)

References 63 publications

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“…Cytokines play an important role in innate immunity, apoptosis, angiogenesis, cell growth and differentiation. Cytokines are also involved in the process of most diseases including cancer 47,48 and reproduction disorders 23,49,50 . It has reported that proinflammatory cytokines could affect BTB permeability and enter into the seminiferous tubules to induce apoptosis of germ cells 51 .…”

Section: Discussionmentioning

confidence: 99%

Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility

Zhang

Yao

Song

et al. 2019

Sci Rep

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Radiation-induced abscopal effect (RIAE) may influence radiotherapy efficiency. However, it is unknown whether RIAE triggers abnormal genetic consequence. We present a novel evidence that, when mice were given fractionated irradiation on right thorax, the ultrastructure of blood-testis barrier was damaged in company with apoptosis induction in testes, and the sperm number and vitality were drastically decreased so that both the fertility and the survival of their offspring were reduced. Protein microarray assay and hormone detection showed that some cytokines especially TNF-α, TGF-β and estradiol in the serum of irradiated mice increased to higher levels in consistent with abscopal damage, and this conditioned serum had toxic effect on TM4 cells in vitro. When the mice were fed with cimetidine, the above abscopal responses were significantly attenuated. This study demonstrates in the first time that the thoracic irradiation (Th-IR) induces structural and functional damage in the distal testes and further cause fertility decline of irradiated male mice, which may have important implications in the strategy development of radiotherapy in avoiding abnormal genetic consequence.

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Section: Discussionmentioning

confidence: 99%

Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility

Zhang

Yao

Song

et al. 2019

Sci Rep

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“…PMS is associated with substantial functional impairment comparable to that observed in dysthymia (Kues et al, 2016) and may lead to impaired work productivity (Chawla et al, 2002; Halbreich et al, 2003) and interfere with marital relationships (Frank et al, 1993), family/homemaking functions (Kuczmierczyk et al, 1992), hobbies and social activities (Heinemann et al, 2010), thereby decreasing health-related quality of life (Farrokh-Eslamlou et al, 2015). Furthermore, PMS is also an important predictor of perinatal depression (Studd and Nappi, 2012; Buttner et al, 2013; Roomruangwong et al, 2016; Stoner et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

et al. 2019

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BackgroundIt is unknown whether lowered steady state levels of sex hormones coupled with changes in those hormones during the menstrual cycle are associated with premenstrual syndrome (PMS).ObjectiveTo examine associations between levels of progesterone and oestradiol during the menstrual cycle and PMS considering different diagnostic criteria for PMS.MethodsForty-one women aged 18–45 years with a regular menstrual cycle completed the Daily Record of Severity of Problems (DRSP) for all 28 consecutive days of the menstrual cycle. Blood was sampled at days 7, 14, 21, and 28 to assay oestradiol and progesterone.ResultsWe developed a new diagnosis of peri-menstrual syndrome, which is characterized by increased DRSP severity in pre and post-menstrual periods and increased scores on the major DRSP dimensions, i.e., depression, physio-somatic symptoms, breast tenderness and appetite, and anxiety. This new diagnosis performed better than classical diagnoses of PMS, including that of the American College of Obstetricians and Gynecologists (ACOG). Lowered steady state levels of progesterone, when averaged over the menstrual cycle, together with declining progesterone levels during the luteal phase predict severity of peri-menstrual symptoms. Steady state levels of oestradiol and declining oestradiol levels during the cycle are also related to DRSP severity although most of these effects appeared to be mediated by progesterone.ConclusionA significant increase in menstrual-cycle related symptoms can best be conceptualized as “peri-menstrual syndrome” and may result from insufficient progesterone production (relative corpus luteum insufficiency), which, in part may result from lowered oestradiol production indicating suboptimal pre-ovulatory follicular development.

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“…In addition, immune-mediated cytokine alterations have been found to play important roles in the underlying mechanism of PPD [4,5,6]. A possible link between PPD and the cytokine-hormone axis has also been reported [7]. However, the entire pathogenesis of PPD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan

Lin

Liu

et al. 2018

IJERPH

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Postpartum depression (PPD) is one of the most common examples of postnatal morbidity, but the subsequent risks of autoimmune diseases in patients with PPD have yet to be fully investigated. This nationwide population-based study utilized data of the National Health Insurance Research Database of Taiwan for the period from 1996 to 2013. In total, 45,451 women with primiparity were identified. Among them, 542 patients with PPD were enrolled as a study group while 2165 matched patients without PPD were enrolled as a control group. The demographic characteristics and comorbidities of the patients were analyzed, and Cox regression analysis was applied to calculate the hazard ratios for the risk of autoimmune diseases. Of the 2707 women enrolled in this study, 469 (17.3%) patients with newly diagnosed autoimmune diseases were identified, including 123 (22.7%) in the PPD group and 346 (16%) in the non-PPD group. After adjusting for confounding factors, it was determined that the patients with PPD had a significantly higher risk of subsequent autoimmune diseases (adjusted hazard ratio (aHR): 1.61, 95% confidence interval (CI): 1.30–1.99; p < 0.001). Specifically, increased risks of pernicious anemia (aHR: 3.85, 95% CI: 2.06–7.22), rheumatoid arthritis (aHR: 2.62, 95% CI: 1.28–5.39), and Graves’ disease (aHR: 1.57, 95% CI: 1.05–2.33) were observed in the PPD group. This study demonstrated that patients with PPD have higher risks of subsequent autoimmune diseases, especially pernicious anemia, rheumatoid arthritis, and Graves’ disease. This useful information provides physicians with clues regarding the associations between autoimmune diseases and PPD.

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The cytokine-hormone axis – the link between premenstrual syndrome and postpartum depression

Cited by 17 publications

References 63 publications

Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility

Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan

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