Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan

Lin, Chien‐Yu; Li, Cheng-Kai; Liu, Jui Ming; Hsu, Ren-Jun; Chuang, Heng-Chang

doi:10.3390/ijerph15081783

Cited by 14 publications

(15 citation statements)

References 40 publications

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“…An effect of the duration of depression was seen, with a higher incidence rate for RA observed in the 3–5 and more than 5 year periods after onset of depression. Postpartum depression and subsequent risk of RA has also been studied in this dataset, with an elevated risk also found (adjusted hazard ratio 2.62, 95% CI 1.28–5.39) [19].…”

Section: Epidemiologic Evidence Of Depression As a Risk Factor For Rhmentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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Purpose of review Rheumatoid arthritis (RA) is associated with negative changes in mental health. This is generally attributed to symptoms of inflammation and the adverse impact of RA on quality of life and functioning. Until recently, causal pathways in the opposite direction have not been fully appreciated. This review examines the recent literature on the risk of RA associated with depression. Recent findings Current literature links depression with an increased risk of RA and with a more detrimental disease course. These effects are likely to be partially mediated by negative effects of depression on coping with RA and on factors such as medication adherence, both of which lead to poorer disease outcomes. Growing evidence also suggests that inflammation is central both to depression and RA and may account for some of the complex interplay between these conditions. Summary Awareness of a bidirectional relationship between depression and RA through a biopsychosocial framework may assist clinicians in maintaining an appropriate index of suspicion about the co-occurrence of these conditions. This review also suggests an important need for integration of rheumatologic and mental health services and generates hypotheses for future research towards a better understanding of both depression and RA.

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Section: Epidemiologic Evidence Of Depression As a Risk Factor For Rhmentioning

confidence: 99%

Depression and the risk of rheumatoid arthritis

Vallerand¹,

Patten²,

Barnabé

2019

Current Opinion in Rheumatology

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“…Our results are consistent with studies showing women with perinatal mental illness are at elevated risk for autoimmune disease. In a population-based cohort of 2707 primiparas in Taiwan, Lin et al 4 showed women with postpartum depression had increased risk, compared to those without postpartum depression, for autoimmune disease (aHR 1.61, 95% CI 1.30–1.99). Likewise, among 148 Dutch women, Bergink et al 5 found women with postpartum psychosis had a higher rate of autoimmune thyroid disease than their peers (19% vs 5%).…”

Section: Discussionmentioning

confidence: 99%

“…There is preliminary evidence that women with perinatal mental illness are at elevated risk for autoimmune disease. 4 , 5 Some authors have postulated that perinatal mental illness is itself an autoimmune disease. 6 Autoimmune diseases are a clinically heterogenous group of disorders defined by an abnormal immunologic reaction to self-antigens resulting in tissue damage and dysfunction of specific organs or entire body systems, including the endocrine, gastrointestinal, liver, neurological, and rheumatological systems.…”

Section: Introductionmentioning

confidence: 99%

“…Studies of the association between perinatal mental illness and autoimmune disease have not considered if women with perinatal and non-perinatal mental illness are differentially vulnerable to autoimmune disease. 4 , 5 Outside of pregnancy, adults with mental illness are at elevated risk of autoimmune diseases, 11 particularly those with brain-reactive antibodies, 12 with mechanisms possibly linked to the sympathetic nervous system and hypothalamic-pituitary-adrenal axis, which regulate immune functioning. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

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Perinatal Mental Illness and Risk of Incident Autoimmune Disease: A Population-Based Propensity-Score Matched Cohort Study

Brown¹,

Wilton²,

Liu³

et al. 2021

CLEP

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Background Studies have demonstrated elevated risk for autoimmune disease associated with perinatal mental illness, but the extent to which this risk is specific to mental illness arising perinatally, and not mental illness generally, is unknown. Our objective was to compare the risk of autoimmune disease in women with mental illness arising within the perinatal period to (1) women with mental illness arising outside the perinatal period and (2) women who did not develop mental illness. Methods We conducted a population-based matched cohort study of women aged 15–49 years with no history of mental illness or autoimmune disease in Ontario, Canada, 1998–2018. The exposed, 60,701 women with mental illness arising between conception and 365 days postpartum were propensity score-matched to (1) 264,864 women with mental illness arising non-perinatally and (2) 469,164 women who did not develop mental illness. Hazard ratios (HR) for autoimmune disease were generated using Cox proportional hazards models. Results The incidence of autoimmune disease was similar among women with mental illness arising perinatally compared to those with mental illness arising non-perinatally (138.4 vs 140.7 per 100,000 person-years; HR 0.98, 95% CI 0.92–1.05), and elevated among women with mental illness arising perinatally compared to those who did not develop mental illness (138.4 vs 88.9 per 100,000 person-years; HR 1.54, 95% CI 1.44–1.64). The HR for the latter comparison was more pronounced for autoimmune disease with brain-reactive antibodies than other autoimmune disease. Conclusion Perinatal mental illness is associated with increased risk of autoimmune disease that is no different than that of mental illness arising non-perinatally. Women with mental illness, regardless of the timing of onset, could benefit from early detection of autoimmune disease.

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“…Grupa tajvanskih autora predlaže ispitivanje koncentracije tiroidnih hormona kod pacijentkinja sa postpartalnom depresijom [21].…”

Section: Diskusijaunclassified

Postpartal depression and thyroid disorders

Jandrić-Kočić¹

2020

Praxis medica

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Introduction: Postpartum depression negatively affects a woman's quality of life and the development of a relationship with her child, which can have far-reaching consequences on the cognitive, behavioral and emotional development of the child. Etiology includes genetic predisposition, sudden hormonal changes, and sociodemographic factors. Case report: A 28-year-old patient, married, mother of a one-month-old boy. She graduated from the High school of economics, unemployed. She appears in the family medicine clinic due to chronic fatigue and bad mood, at the insistence of her husband, who thinks that she needs professional help. She grew up in a harmonious family. He gets along well with his wife, there are no existential problems. It denies previous illnesses. Neat appearance, inconspicuous posture and behavior, psychomotor diskette slowed down, more sparse spontaneous verbalization, slightly compromised volitional instinctual dynamisms, lowered basic mood. In the laboratory findings, hypothyroidism with elevated thyroid peroxidase antibody and antithyreoglobulin antibodies is detected. The thyroid ultrasound verifies the right lobe of 46x14x15mm, the left lobe of 48x13x12mm, inhomogeneous and easily hypoechoic structure. The Edinburgh Postnatal Depression Scale indicates the presence of depression (total score 18). The patient is referred for a consultative examination by a psychiatrist and a nuclear medicine specialist. Psychiatrist indicates the introduction of Sertralin 50 mg tablets (1x1/2 for the first seven days, then 1x1) and Bromasepam tablets 1,5 mg (2x1/2), nuclear specialist Levotiroskin sodium tablets 50 mcg (1x1/2 for 5 days and 1x1 for 2 days). After six months, withdrawal of the symptoms of the disease and exclusion of therapy by a psychiatrist. Conclusion: Autoimmune thyroid disease is a significant and often unrecognized cause of postpartum depression. Early detection and timely therapeutic intervention of these have a significant role in the prevention and successful treatment of postpartum depression.

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Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan

Cited by 14 publications

References 40 publications

Depression and the risk of rheumatoid arthritis

Depression and the risk of rheumatoid arthritis

Perinatal Mental Illness and Risk of Incident Autoimmune Disease: A Population-Based Propensity-Score Matched Cohort Study

Postpartal depression and thyroid disorders

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