The cystadenoma and related nonfunctional tumors of the pancreas.Pathogenesis, classification, and significance

Glenner, George G.; Mallory, G. Kenneth

doi:10.1002/1097-0142(195609/10)9:5<980::aid-cncr2820090519>3.0.co;2-s

Cited by 68 publications

(6 citation statements)

References 19 publications

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“…The nuclei of carcinoid tumours have a degree of uniformity seldom seen in acinar cell carcinomas, and the fine stippling of the nuclear chromatin of carcinoid tumours is not a feature that I acinar cell neoplasm. Glenner and Mallory (1956) referred to adenomatous hyperplasia of acinar cells but did not find a tumour comparable to the one described by Haberer. They illustrated a microscopic tumour which they called a fibroadenoma; this probably had an acinar cell origin.…”

Section: Discussionmentioning

confidence: 76%

Acinar cell neoplasms of the exocrine pancreas.

Webb¹

1977

J Clin Pathol

121

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SYNOPSIS The pathological features of 12 acinar cell neoplasms of the pancreas are described; these comprise 11 carcinomas, of which seven were pure acinar cell growths and four were mixed acinar and ductal carcinomas, and one adenoma. These tumours occurred in a series of 105 during the period 1962-75. Thrombotic endocarditis developed in three out of the 11 carcinoma cases. The distinctive histological features of these neoplasms and the means of differentiating them from anaplastic carcinomas and certain other carcinomas, for example, islet cell carcinomas, oat cell carcinomas, and carcinoid tumours, are discussed. The poor prognosis of pancreatic cancers is emphasized, and reasons are put forward for believing that future epidemiological studies may need to take account of the histological types of pancreatic carcinoma.

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Section: Discussionmentioning

confidence: 76%

Acinar cell neoplasms of the exocrine pancreas.

Webb¹

1977

J Clin Pathol

121

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“…Based on conventional light microscopy, the histogenesis of the two main types of cystadenoma has not been entirely settled. The prevalent view has been that cystadenoma is derived from the epithelium of the duct system but with some confusion as to the cell of origin, centroacinar or duct cell (Glenner & Mallory 1956, Campbell & Cruickshank 1962Becker, et al 1965, Hodgkinson et a/. 1978.…”

Section: Discussionmentioning

confidence: 99%

Cystadenoma of the pancreas: a histological, histochemical and ultrastructural study of seven cases

Bogomoletz¹,

Adnet²,

Widgren³

et al. 1980

Histopathology

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Seven cases of cystadenoma of the pancreas were examined in detail histologically and histochemically and two variants were identified: a microcyst type lined by glycogen-rich cuboidal epithelium which also secretes some neutral mucins; and macrocystic type lined exclusively by mucus-secreting columnar cells which secrete predominantly sulphated acidic mucins with some neutral mucins. Electron microscopy of two cases of the microcystic variant showed neoplastic cells with an ultrastructure comparable to that of centroacinar cells of the normal exocrine pancreas.

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“…2 On the other hand, pancreatic tumors with mixed differentiation of both exocrine and endocrine components together have also vary rarely been reported. [2][3][4][5][6][7][8][9] These tumors with mixed differentiation have been described by the terms "mixed duct-acinar," "duct-islet," "acinar-islet," or "duct-acinar-islet cell tumors" based on their components. Mixed duct-acinarislet cell tumors such as the one observed in our case are thus especially rare.…”

Section: Discussionmentioning

confidence: 99%

Mixed Duct-Acinar-Islet Cell Tumor of the Pancreas: Report of a Case

Tanakaya¹,

Teramoto

Konaga³

et al. 2001

Surgery Today

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A 72-year-old Japanese woman presented at our hospital complaining of altered consciousness on arising every morning. The laboratory findings showed hypoglycemia and hyperinsulinemia. Abdominal ultrasonography revealed a tumor in the body of the pancreas. With a diagnosis of insulinoma, a surgical excision of the tumor was performed. A light microscopic examination and an immunohistochemical study revealed the tumor to consist of duct, acinar, and islet cell components. Mixed tumors of the pancreas are rare, and their clinical features and pathogenesis remain unclear. A further accumulation of clinical cases as well as a large number of histopathological studies on these rare mixed tumors is needed.

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The cystadenoma and related nonfunctional tumors of the pancreas.Pathogenesis, classification, and significance

Cited by 68 publications

References 19 publications

Acinar cell neoplasms of the exocrine pancreas.

Acinar cell neoplasms of the exocrine pancreas.

Cystadenoma of the pancreas: a histological, histochemical and ultrastructural study of seven cases

Mixed Duct-Acinar-Islet Cell Tumor of the Pancreas: Report of a Case

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