Cystadenoma of the pancreas: a histological, histochemical and ultrastructural study of seven cases

Bogomoletz, W V; Adnet, J. J.; Widgren, S; Stavrou, M; McLaughlin, James E.

doi:10.1111/j.1365-2559.1980.tb02924.x

Cited by 46 publications

(19 citation statements)

References 11 publications

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“…Finally they were also positive for CA 19-9 and occasionally for B 72.3, but negative for CEA (B/itge et al 1986;Shorten et al 1986;Alpert et al 1988;Helpap and Vogel 1989). These results suggest that the cells composing MCA and SOIA are of the same phenotype and are probably derivatives of the centroacinar cell (Lo et al 1977;Bogomoletz et al 1980;Alpert et al 1988).…”

Section: Discussionmentioning

confidence: 96%

“…MCA of the pancreas, as classified by Compagno and Oertel (1978) and described by many other authors (Campbell and Cruickshank 1962;Hodgkinson et al 1978;Bogomoletz et al 1980;Shorten et al 1986;Yamaguchi and Enjoji 1987;Alpert et al 1988;Helpap and Vogel 1989;Pyke et al 1992), presents as a well-circumscribed tumour with a sponge or honeycomb-like cystic cut surface that shows a central, stellate, occasionally calcified scar. This lesion is virtually always benign.…”

Section: Discussionmentioning

confidence: 98%

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Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma

Egawa¹,

Maillet²,

Schröder³

et al. 1994

Vichows Archiv A Pathol Anat

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Serous cystic tumours of the pancreas are uncommon and are usually classified as microcystic adenomas (MCA). As new types of serous cystic tumours of this organ have been reported we reviewed a series of 14 lesions and from macroscopic findings two groups were distinguished: ten tumours revealed the features of MCA, while four were clearly distinct from MCA. Grossly, the latter tumours showed only few cysts which were irregularly assembled in fibrous stroma. On the cut surface, there was neither a central stellate scar nor a circumscribed tumour border, features characterizing MCA. Microscopically, the cysts were lined by cuboidal, non-mucin-producing cells. Immunocytochemical staining for cytokeratins 7, 8, 18 and 19 revealed a ductal phenotype. All non-MCA were found in the head of the pancreas and three of them occurred in men. There were no tumour recurrences or signs or malignant transformation after resection (mean follow-up, 2.9 years). These results suggest that there are serous cystic tumours distinct from MCA which may represent another variant of the category of serous cystic adenomas of the pancreas. We propose the term serous oligocystic and ill-demarcated adenoma (SOIA) for these tumours. It is possible that the recently described macrocystic sybtype of serous cystadenoma and SOIA and variants of the same tumour.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma

Egawa¹,

Maillet²,

Schröder³

et al. 1994

Vichows Archiv A Pathol Anat

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“…The MCN of the pancreas, as classified by Compagno and Oertel (12) and described by many other authors (13)(14)(15)(16)(17)(18), presents as a well circumscribed unilocular or multilocular cystic tumor, which, in Ͼ90% of the cases, is localized in the body and tail of the pancreas of women (18) No other cystic lesions and neoplasms of the pancreas (1) cause problems in the differential diagnosis of MNCs. Thus MNCs can easily be distinguished from intraductal papillary-mucinous neoplasms by their lack of communication with the duct system (21); from solid pseudopapillary neoplasms by their lack of female predominance, pseudocystic degeneration, and cellular features (22)(23)(24); from serous cystic tumors by their lack of serous differentiation (25); from paraampullary duodenal wall cysts by their location in the duodenal wall and submucosa (2,26); and from the recently described acinar cystic transformation (5) and cystic endocrine tumors (27) by their lack of acinar or endocrine cell differentiation, respectively.…”

Section: Discussionmentioning

confidence: 99%

Mucinous Nonneoplastic Cyst of the Pancreas: A Novel Nonneoplastic Cystic Change?

et al. 2002

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Cystic lesions and neoplasms of the pancreas are uncommon, but they are of special interest because they can usually be cured by resection. During the last decade, the spectrum of these tumors has increased considerably. We present a series of five cystic lesions of the pancreas that differ from all categories described so far. The patients affected by these tumors were three men and two women (mean age, 57 y). Four lesions were unifocal and involved the head of the pancreas; one was multifocal and involved the pancreatic head and tail. Grossly, these tumors presented as unilocular or multilocular thin-walled cysts that contained turbid fluid, or, in two cases, blood, and lacked any communication with the duct system. Microscopically, the cysts were lined by cuboidal to columnar mucin-producing cells, supported by a small band of dense fibrous stroma. Immunocytochemically, the epithelial cells were positive for cytokeratins 7, 8, 18, 19, and 20 (except one), and Ca 19-9 but were negative for trypsin, CEA, synaptophysin, chromogranin A, calretinin, and ␣-inhibin. In four of the five lesions, the epithelial cells expressed MUC5AC, and in one of the five, MUC1. MUC2 and MUC6 were not expressed in any of the lesions. The stromal cells lacked the nuclear progesterone positivity that is typical of mucinous cystic neoplasms. During a mean follow-up period of 2 years, there were no recurrences or cases of malignant transformation after resection. The results suggest that these cystic lesions are distinct from mucinous cystic neoplasms, the most important entity in the differential diagnosis. Because they may represent a nonneoplastic cystic change of the pancreas, we propose the descriptive term mucinous nonneoplastic cyst for these tumors of unknown pathogenesis.

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“…It is thought to arise from the centroacinar cells of the pancreas. 1,6,8,9 Rarely does this tumor transform to a malignancy, although it may be associated with pancreatic duct adenocarcinoma. 10 The lesion itself tends to be discovered secondary to compressive symptoms such as gastrointestinal or biliary tract obstruction or incidentally on radiologic examinations.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Fine Needle Aspiration Cytology Diagnosis of Microcystic Adenoma of the Pancreas: Fact or Fiction?

Fitzhugh¹,

Mirani²,

Aisner³

et al. 2008

Acta Cytologica

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Cystadenoma of the pancreas: a histological, histochemical and ultrastructural study of seven cases

Cited by 46 publications

References 11 publications

Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma

Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma

Mucinous Nonneoplastic Cyst of the Pancreas: A Novel Nonneoplastic Cystic Change?

Preoperative Fine Needle Aspiration Cytology Diagnosis of Microcystic Adenoma of the Pancreas: Fact or Fiction?

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