2019
DOI: 10.1093/toxsci/kfz176
|View full text |Cite
|
Sign up to set email alerts
|

The Customizable E-cigarette Resistance Influences Toxicological Outcomes: Lung Degeneration, Inflammation, and Oxidative Stress-Induced in a Rat Model

Abstract: Despite the knowledge gap regarding the risk-benefit ratio of the electronic cigarette (e-cig), its use has grown exponentially, even in teenagers. E-cig vapor contains carcinogenic compounds (eg, formaldehyde, acetaldehyde, and acrolein) and free radicals, especially reactive oxygen species (ROS) that cause toxicological effects, including DNA damage. The role of e-cig voltage customization on molecule generation has been reported, but the effects of the resistance on e-cig emissions and toxicity are unknown.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
42
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 37 publications
(42 citation statements)
references
References 73 publications
0
42
0
Order By: Relevance
“…As the manufacturing variation in coils increases, the potential adverse consequences of changes in HPHC emissions also increases. It has been reported that coils with lower resistance values may have higher negative health impacts [ 23 , 24 , 25 , 27 ]. Therefore, it is essential to develop a full understanding of the manufacturing variation in coil resistance associated with electronic cigarettes.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As the manufacturing variation in coils increases, the potential adverse consequences of changes in HPHC emissions also increases. It has been reported that coils with lower resistance values may have higher negative health impacts [ 23 , 24 , 25 , 27 ]. Therefore, it is essential to develop a full understanding of the manufacturing variation in coil resistance associated with electronic cigarettes.…”
Section: Discussionmentioning
confidence: 99%
“…Their research also reported that vapor generated by coils with lower resistances has a higher negative impact on cell viability. The same research group [ 24 ] also showed in a separate work in 2019 that the production of selected aldehydes increased as coil resistance decreased from 1.5 (Ω) to 0.25 (Ω). The effects of the aerosols generated by the two coils on Sprague–Dawley rats was studied.…”
Section: Introductionmentioning
confidence: 96%
“…S. et al used two identical devices containing the same e-liquid (PG/VG ratio, nicotine concentration, and flavors) but equipped with two different coils (1.5 and 0.25 ohm) to obtain total wattages of 8 ± 2 W and 40 ± 5 W, respectively. Aerosols generated at higher wattage induced a much more robust inflammatory response in rats compared to aerosols generated at lower wattage [117], suggesting that device characteristics are key factors that affect inflammation induced by e-cigarette aerosols.…”
Section: Inflammationmentioning
confidence: 98%
“…NNK in turn can be metabolised to methyldiazohydroxide, which can methylate DNA, and to pyridyl-butyl derivatives, which can also form DNA adducts, and to formaldehyde, which like other aldehydes can form cyclic 1,N2-propano-dG DNA adducts, including γ-hydroxy-1,N2-propano-deoxyguanosines, leading to DNA damage and tumorigenesis (Lee et al 2018). Two reports from a separate research group have also proposed an increase in cancer risk following EC exposure in rats as a consequence of both free radical and reactive oxygen species generation leading to oxidative DNA damage (increase in pulmonary 8-oxo-dG DNA adducts) and a reduction in expression levels of antioxidant enzymes (catalase, superoxide dismutase, NAD(P)H quinone reductase) (Canistro et al 2017;Cirillo et al 2019). In addition, these authors demonstrated an increase in cytochrome P450 activities including those involved in activation of chemical procarcinogens (CYP1A1/2, CYP2B1/2, CYP3A1/2) and a decrease in enzymes involved in carcinogen detoxification (UDPGT, GST).…”
Section: What Are the Adverse Effects Of E-cigarettes?mentioning
confidence: 99%
“…2017; Cirillo et al . 2019). In addition, these authors demonstrated an increase in cytochrome P450 activities including those involved in activation of chemical procarcinogens (CYP1A1/2, CYP2B1/2, CYP3A1/2) and a decrease in enzymes involved in carcinogen detoxification (UDPGT, GST).…”
Section: Introductionmentioning
confidence: 99%