The current use and evolving landscape of nutraceuticals

Chopra, Avijeet; Lordan, Ronan; Horbańczuk, Olaf K.; Atanasov, Atanas G.; Chopra, Ishveen; Horbańczuk, J.O.; Jóźwik, Artur; Huang, Linfang; Pirgozliev, V.; Banach, Maciej; Battino, Maurizio; Arkells, Nicolas

doi:10.1016/j.phrs.2021.106001

Cited by 80 publications

(57 citation statements)

References 68 publications

(89 reference statements)

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“…The market for dietary supplements that promise to boost cognitive functioning is consistently growing (Chopra et al, 2022). The freely-accessible catecholamine precursor L-Tyrosine has increasingly gained attention in (cognitive) neuroscience.…”

Section: Introductionmentioning

confidence: 99%

A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting

Mathar

Abdoust

Tuszus

et al. 2022

Preprint

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Supplementation with the catecholamine precursor L-Tyrosine might enhance cognitive performance, but overall findings are mixed. Here, we investigate the effect of a single dose of tyrosine (2g) vs. placebo on two key aspects of catecholamine-dependent decision-making: model-based reinforcement learning (2-step task) and temporal discounting, using a double-blind, placebo-controlled, within-subject design (n=28 healthy male participants). We leveraged drift diffusion models in a hierarchical Bayesian framework to jointly model participants' choices and response times in both tasks. Furthermore, comprehensive autonomic monitoring (heart rate, heart rate variability, pupillometry, spontaneous eye-blink rate) was performed both pre- and post-supplementation, to explore potential physiological effects of supplementation. Across tasks, tyrosine consistently reduced participants' RTs without deteriorating task-performance. Diffusion modeling linked this effect to attenuated decision-thresholds in both tasks and further revealed increased model-based control (2-step task) and (if anything) attenuated temporal discounting. On the physiological level, participants pupil dilation was predictive of the individual degree of temporal discounting. Tyrosine supplementation reduced physiological arousal as revealed by increases in pupil dilation variability and reductions in hear rate. Supplementation-related changes in physiological arousal predicted individual changes in temporal discounting. Our findings provide first evidence that tyrosine supplementation might impact psychophysiological parameters, and suggest that modeling approaches based on sequential sampling models can yield novel insights into latent cognitive processes modulated by amino-acid supplementation.

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Section: Introductionmentioning

confidence: 99%

A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting

Mathar

Abdoust

Tuszus

et al. 2022

Preprint

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“…The interest in natural products and nutraceuticals has increased because people are more interested in their bodies, health, and aging [7,[38][39][40]. In the same way, the Kombucha market is growing and becoming quite famous globally, including family businesses (small businesses), which have gained considerable prominence in this field.…”

Section: Kombucha Market and Safetymentioning

confidence: 99%

Kombucha: Perceptions and Future Prospects

Batista

Penas

Pintado

et al. 2022

Foods

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Background: Kombucha is an increasingly consumed product classified as a nutraceutical. Legislative efforts about these products remain confusing and without global harmonization. This natural product has been developed to improve or promote physical and mental health. However, it needs regulatory guidelines to control the production and guarantee the product’s efficacy and safety. Aim: The study intends to draw attention to the need for regulatory guidelines and the potential of this product in the market and peoples’ health. Key findings and conclusions: The lack of regulation and the low level of literacy about this product can limit its development, marketing, and impact on health. Thus, it is essential to highlight the potential value of this product and invest in its development and marketing. Likewise, it is important to spread awareness among the population of these products and their impacts on people’s health. Thus, this study focuses on a pertinent theme and alerts to the need for legislation for these products, to draw attention to the inexistent legislative control and the consequent need for regulatory guidelines for better and safer production and consumption.

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“…Table 1 shows the major classes of functional foods, from the nutraceutical context, and their associated bioactive components/effects. The functional food classification would include beverages (Nutraceutical beverages) (Saeed et al, 2019;Dí az et al, 2020;Bulman et al, 2021), fermented foods (Islam et al, 2019;Vasilean et al, 2021;Yun et al, 2021), fruits (Ellis, 2021;Lim et al, 2021), herbs and spices (Ahmad et al, 2020;Pandey et al, 2022;Chopra et al, 2022), honey (Anfang et al, 2018;Grüter, 2020;Berenbaum and Calla, 2021;Martinez-Armenta et al, 2021), legumes (Barman et al, 2018;Carrera et al, 2021), nuts (Del Gobbo et al, 2015;ARS, 2019;Ros et al, 2021), seafood (fishes) (Te ´ lessy, 2019; Ashraf et al, 2020;Ellis, 2021), seeds (Kawakami et al, 2015;Khosravi-Boroujeni et al, 2017;Robertson, 2017;Suryapal et al, 2021), vegetables (Saiwal et al, 2019;Arya et al, 2019), as well as whole grains (Priebe and McMonagle, 2016;Kelly et al, 2017;Zabolotneva et al, 2022), which will be further discussed in this section. Further illustrating the abovementioned, some vegetables with their associated nutraceutical potentials are presented in Table 2, in terms of plant species, image display, common cultivars and parts commonly used.…”

Section: Common Functional Foods From the Nutraceutical Context And T...mentioning

confidence: 99%

Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention - An overview

Awuchi¹,

Okpala

2022

JFB

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Nutraceuticals play wide range of important roles, from health promotion, increasing life expectancy, maintaining body cell integrity, to reducing the risks of many diseases. As consumers continue to be attracted to nutraceuticals, such as superfoods, vegetables, fruits, high-protein foods, eating healthy intertwines with finding the right balance. Nowadays, the nutraceutical industries are among the many that target to meet the growing and dynamic consumers’ expectations. Adding to their increasing interest and general acceptability, consumers continue to be attracted to nutraceuticals. How nutraceuticals, especially functional foods, etc., help in tackling health challenges increase the interest among several researchers in this subject area, and given the ever-growing need across communities around the globe for healthy living, strengthens the need for continued synthesis of published information to supplement existing knowledge. This overview, therefore, discusses natural nutraceuticals, especially functional foods, their major bioactive components, formulation, health benefits for disease prevention.

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The current use and evolving landscape of nutraceuticals

Cited by 80 publications

References 68 publications

A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting

A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting

Kombucha: Perceptions and Future Prospects

Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention - An overview

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