Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention - An overview

Awuchi, Chinaza Godswill; Okpala, Charles Odilichukwu R.

doi:10.31665/jfb.2022.18317

Cited by 18 publications

(6 citation statements)

References 144 publications

(214 reference statements)

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“…Resveratrol (Figure 3) is a polyphenol that occurs in several plants, including peanuts (Awuchi & Okpala, 2022). It inhibits the survival of AML cells via activation of Fas-mediated apoptosis and caspase signaling.…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

Egbuna

Patrick‐Iwuanyanwu

Onyeike

et al. 2023

Food Science & Nutrition

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This systematic review identified various bioactive compounds which have the potential to serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy that arises from the dysregulation of cell differentiation, proliferation, and cell death. The risk factors associated with the onset of AML include long‐term exposure to radiation and chemicals such as benzene, smoking, genetic disorders, blood disorders, advancement in age, and others. Although novel strategies to manage AML, including a refinement of the conventional chemotherapy regimens, hypomethylating agents, and molecular targeted drugs, have been developed in recent years, resistance and relapse remain the main clinical problems. In this study, three databases, PubMed/MEDLINE, ScienceDirect, and Google Scholar, were systematically searched to identify various bioactive compounds with antileukemic properties. A total of 518 articles were identified, out of which 59 were viewed as eligible for the current report. From the data extracted, over 60 bioactive compounds were identified and divided into five major groups: flavonoids, alkaloids, organosulfur compounds, terpenes, and terpenoids, and other known and emerging bioactive compounds. The mechanism of actions of the analyzed individual bioactive molecules differs remarkably and includes disrupting chromatin structure, upregulating the synthesis of certain DNA repair proteins, inducing cell cycle arrest and apoptosis, and inhibiting/regulating Hsp90 activities, DNA methyltransferase 1, and histone deacetylase 1.

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Section: Discussionmentioning

confidence: 99%

Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

Egbuna

Patrick‐Iwuanyanwu

Onyeike

et al. 2023

Food Science & Nutrition

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“…Harm reduction infused into community-based initiatives have been shown to help many with the prevalence of drug abuse and use of NPS. Many community-based initiatives used in many other intervention measures can also be employed to tackle excess use and abuse of NPS [235][236][237][238][239][240]. Fasakin et al [241], Corazza et al, [242], and Johansen et al…”

Section: Community-based Initiatives To Combat Nps and Harm Reduction...mentioning

confidence: 99%

New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions

Awuchi

Aja

Mitaki

et al. 2023

Journal of Chemistry

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Across communities worldwide, various new psychoactive substances (NPSs) continue to emerge, which worsens the challenges to global mental health, drug rules, and public health risks, as well as combats their usage. Specifically, the vast number of NPSs that are currently available, coupled with the rate at which new ones emerge worldwide, increasingly challenges both forensic and clinical testing strategies. The well-established NPS detection techniques include immunoassays, colorimetric tests, mass spectrometric techniques, chromatographic techniques, and hyphenated types. Nonetheless, mitigating drug abuse and NPS usage is achievable through extensive community-based initiatives, with increased focus on harm reduction. Clinically validated and reliable testing of NPS from human samples, along with community-driven solution, such as harm reduction, will be of great importance, especially in combating their prevalence and the use of other illicit synthetic substances. There is a need for continued literature synthesis to reiterate the importance of NPS, given the continuous emergence of illicit substances in the recent years. All these are discussed in this overview, as we performed another look into NPS, from differentiating the major groups and identifying with laboratory testing challenges to community-based initiatives.

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“…In addition to fat (41%), protein (20%), fiber (28%), phenolic compounds, a‐linolenic acid, and mucilage, flaxseed ( Linum usitatissimum ), a plant belonging to the family Linaceae, also contain other important compounds, including a range of bioactive phenols, including flavonoids, lignan, and phenolic acids (Awuchi & Okpala, 2022 ; Egbuna et al, 2021 ). SDG levels (0.6–1.8 g/100 g, or 1%–4% by weight) in flaxseed vary depending on growing method, location of plant development, and duration of cultivation (Kezimana et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions

Noreen

Rehman

Tufail

et al. 2023

Food Science & Nutrition

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Fennel seeds and flaxseed have been traditionally used against many medical ailments due to their medicinal characteristics. The aim of the study was to investigate the health properties of secoisolariciresinol diglucoside (SDG) and anethole from flaxseed and fennel seeds in rats fed with high‐fat diet. Histopathological changes in the heart and liver were also examined. Sixty rats were divided into two main groups. Group I (10 rats) was used as a negative control group and fed on the basal diet only. Group II (50 rats) was fed a hypercholesterolemic diet but not given any drugs during the trial for 2 weeks. This group was further divided into five subgroups (10 rats each). One of them was fed on the basal diet and used as a positive control group. However, the other four subgroups were fed on basal diets and anethole (20 mg/kg/day, orally), SDG (20 mg/kg/day, orally), a mixture of anethole + SDG (10 + 10 mg/kg/day, orally), and atorvastatin (10 mg/kg/day, orally) for 6 weeks. Compared to control, treatment with a combination of anethole + SDG showed a significant (p ≤ .05) improvement in serum levels of triglyceride (TG) (137.88 ± 1.61 mg/dL), total cholesterol‐(TC) (180.12 ± 8.99 mg/dL), LDL‐C (46.40 ± 6.67 mg/dL), VLDL‐C (11.81 ± 1.07 mg/dL), aspartate aminotransferase (AST) (75.97 ± 6.92 U/L), alanine aminotransferase (ALT) (34.83 ± 2.17 U/L), alkaline phosphatase (ALP) (130.65 ± 1.05 U/L), and malondialdehyde (MDA) (30.12 ± 1.89 mmol/g), and improved activities of catalase (70.99 ± 3.29 U/g) and superoxide dismutase (SOD) (35.13 ± 2.53 U/dL) enzymes while SDG and anethole group had relatively less impact. Atorvastatin also improved serum levels of triglyceride, total cholesterol, LDL‐C, and VLDL‐C significantly and rose serum high‐density lipoprotein cholesterol (HDL‐C) levels considerably meanwhile it had a minor but negative impact on AST, ALT, and ALP, and negligible impact on activities of MDA, CAT, and SOD enzymes compared to the positive control group. The study revealed that combining anethole and SDG may improve dyslipidemia, improve lipid profile, decrease risks of chronic heart diseases, increase HDL‐C, and enhance antioxidant enzymes' activities.

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Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention - An overview

Cited by 18 publications

References 144 publications

Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

Phytochemicals and bioactive compounds effective against acute myeloid leukemia: A systematic review

New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions

Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions

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