The Current State of Topical Burn Treatments: a Review

Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications

“…On the one hand, silver binds to some amino acids, denaturating proteins, as well as to surface membranes, causing proton leaks that ultimately lead to cell death by a non-specific biocide mechanism. On the other hand, sulfadiazine moiety acts like a typical sulfonamide, inhibiting bacterial DHPS and affecting folic acid synthesis [39].…”

Spatiotemporal distribution and speciation of silver nanoparticles in the healing wound

“…A new generation of Ag-based dressings have been designed, consisting of biocompatible scaffolds (meshes, foams, gels or composites) impregnated with Ag as soluble salts, AgCl, microcristalline Ag sulfadiazine, or as a metallic film. 11,12 One of the most promising approaches bases on metallic Ag nanoparticles (AgNPs). 13 The nanoparticulate forms of Ag exhibit unique physico-chemical properties such as nanometric size, crystal structures and enhanced surface reactivity, which can be specifically designed for an improved stability in biological media, 10,14 enhanced affinity for cellular membranes to favour the uptake, and calibrated dissolution for delivery of the ion to intracellular targets.…”

Current approaches of nanomedicines in the market and various stage of clinical translation

“…With a median particle size of about 150 nm, Sebashells exhibits plasmon resonance with strong absorption at 800 nm and can selectively destroy sebaceous glands, delivered to target sites by mechanical vibration 167 . Acticoat, a silver nanocrystal-coated polyethylene net for burn treatments, can release silver ions to kill microbes via a variety of mechanism including blocking the cell respiration pathway, interfering with components of the microbial electron transport system, and producing DNA damage 168 .…”