The Current State of Chronic Dialysis Treatment in Japan.

Nakai, Shigeru; Shinzato, Takahiro; Sanaka, Tsutomu; Kikuchi, Kenjiro; Kitaoka, Tateki; Shinoda, Takeshi; Yamazaki, Chikao; Sakai, Rumi; Omori, Hiroyuki; Morita, Osamu; Iseki, Kunitoshi; Kubo, Kazuo; Tabei, Kaoru; Masakane, Ikuto; Fushimi, Kiyohide; Wada, Atsushi; Miwa, Naoko; Akiba, Takashi

doi:10.4009/jsdt.35.1155

Cited by 48 publications

(36 citation statements)

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“…The original renal diseases were chronic glomerulonephritis in 198 patients (40.2%), diabetic nephropathy in 138 patients (28.0%), nephrosclerosis in 43 patients (8.7%), polycystic kidney disease in 18 patients (3.7%), gouty kidney in 3 patients (0.6%), and unknown in 98 patients (18.9%). The rates of these diseases were similar to those in the general Japanese population undergoing maintenance dialysis (10).…”

Section: Patientssupporting

confidence: 57%

Frequency of Gouty Arthritis in Patients with End-stage Renal Disease in Japan

et al. 2005

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Objective The purpose of this study was to investigate gouty arthritis in Japanese patients with end-stage renal disease (ESRD).Methods Questionnaires plus patient interviews and reviews of medical records were used to investigate gouty arthritis in 493 Japanese patients with ESRD receiving maintenance dialysis.Results The frequency of gouty arthritis was 4.1% for female patients and 15.4% for male patients greater than 2 years before the start of dialysis, and 0.6% for female patients and 7.7% for male patients less than 2 years before the start of dialysis. After the start of dialysis the frequency was 3.4% for the first 2 years and 1.2% thereafter in male patients, but no gouty arthritis appeared in female patients. Although the annual number of gouty attacks was 2.0±4.2 greater than 2 years before the start of dialysis, and 1.9±6.6 less than 2 years before the start of dialysis, the annual number of attacks decreased significantly after the start of dialysis to 0.2±0.7 in the first 2 years and 0.1±0.6 thereafter.Conclusions The frequency of gouty arthritis in Japanese patients with ESRD is similar to that of patients with hyperuricemia in the general population and it is decreased slightly before dialysis; however, the frequency decreases markedly after dialysis.

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Section: Patientssupporting

confidence: 57%

Frequency of Gouty Arthritis in Patients with End-stage Renal Disease in Japan

et al. 2005

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“…Diabetic nephropathy is the leading cause of end-stage renal disease (ESRD) in Western countries as well as in Japan (Akmal 2001;Collins et al 2006;Nakai et al 2002). Cumulative evidence indicates that genetic susceptibility plays an important role in the development and progression of diabetic nephropathy, and the susceptibility to diabetic nephropathy seems to be determined by multiple genetic and environmental factors (Krolewski et al 1987;Quinn et al 1996;Susztak et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the 3′ UTR in the neurocalcin δ gene affect mRNA stability, and confer susceptibility to diabetic nephropathy

et al. 2007

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Using a large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese type 2 diabetic patients, we have identified a gene encoding neurocalcin delta (NCALD) as a candidate for a susceptibility gene to diabetic nephropathy; the landmark SNP was found in the 3' UTR of NCALD (rs1131863: exon 4 +1340 A vs. G, P = 0.00004, odds ratio = 1.59, 95% CI 1.27-1.98). We also discovered two other SNPs in exon 4 of this gene (+999 T/A, +1307 A/G) that showed absolute linkage disequilibrium to the landmark SNP. Subsequent in vitro functional analysis revealed that synthetic mRNA corresponding to the disease susceptible haplotype (exon 4 +1340 G, +1307 G, +999 A) was degraded faster than mRNA corresponding to the major haplotype (exon 4 +1340 A, +1307 A, +999 T), and allelic mRNA expression of the disease susceptibility allele was significantly lower than that of the major allele in normal kidney tissues. In an experiment using a short interfering RNA targeting NCALD, we found that silencing of the NCALD led to a considerable enhancement of cell migration, accompanied by a significant reduction in E-cadherin expression, and by an elevation of alpha smooth muscle actin expression in cultured renal proximal tubular epithelial cells. We also identified the association of the landmark SNP with the progression of diabetic nephropathy in a 8-year prospective study (A vs. G, P = 0.03, odds ratio = 1.91, 95% CI 1.07-3.42). These results suggest that the NCALD gene is a likely candidate for conferring susceptibility to diabetic nephropathy.

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“…The incidence of end-stage renal disease (ESRD) is high in Okinawa compared to other parts of Japan (1,2). High protein intake, if confirmed, may be one of the explanations for the high incidence of ESRD, since high protein intake has been shown to have a hazardous hemodynamic effect on glomerular filtration (3).…”

Section: Introductionmentioning

confidence: 99%