Estimated Protein Intake and Blood Pressure in a Screened Cohort in Okinawa, Japan

Iseki, Kunitoshi; Iseki, Chiho; Itoh, Kazuyoshi; Sanefuji, Miho; Uezono, Keiko; Ikemiya, Yoshiharu; Fukiyama, Koshiro; Kawasaki, Terukazu

doi:10.1291/hypres.26.289

Cited by 15 publications

(14 citation statements)

References 22 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several previous studies reported an inverse association of total protein intake with systolic and/or diastolic blood pressure (1)(2)(3)(4)(5)(6)8). In the present study, total protein intake was inversely associated with both systolic and diastolic blood pressure; after further adjustment for nutritional factors, the association with diastolic blood pressure remained statistically significant.…”

Section: Discussionsupporting

confidence: 67%

“…Compared with previous Japanese and Chinese studies (6,8,9), we had a large number of subjects and conducted a more through adjustment for confounding variables. including alcohol intake.…”

Section: Discussionmentioning

confidence: 99%

“…Total protein intake, estimated with a 24-h dietary recall (1)(2)(3), and measurement of urinary urea nitrogen excretion, a urinary biomarker of protein intake (4,5), were found to be inversely associated with systolic (1,(3)(4)(5) and diastolic (1)(2)(3)(4)(5) blood pressure. A recent Japanese study reported that total protein intake, estimated on the basis of urea nitrogen and creatinine concentrations in spot urine, was inversely associated with diastolic blood pressure among men (6).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS)

Umesawa

Sato

Imano

et al. 2009

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Background: An inverse association between protein intake and blood pressure has been reported in Western countries. However, the evidence is limited for Asians, whose protein sources are different from those in Western populations. Objectives: The objective was to examine the association between protein intake and blood pressure in Japanese adults. Methods: We conducted a population-based, cross-sectional study of 7585 subjects (3499 men and 4086 women) from 40 to 69 y of age living in 5 communities in Japan. Dietary intakes of total, animal, and plant protein were estimated by a single 24-h dietary recall. We then examined the associations between dietary intake of those proteins and blood pressure after adjustment for age, sex, community, body mass index, antihypertensive medication use, ethanol intake, smoking, and dietary intakes of sodium, potassium, and calcium. Results: After adjustment for cardiovascular disease risk factors, a 25.5-g/d increment in total protein intake was associated with a decrease in systolic blood pressure of 1.14 mm Hg (P , 0.001) and in diastolic blood pressure of 0.65 mm Hg (P , 0.001), and a 19.9-g/d increment in animal protein intake was associated with a decrease in systolic blood pressure of 1.09 mm Hg (P , 0.001) and in diastolic blood pressure of 0.41 mm Hg (P ¼ 0.003). A 13.1-g/d increment in plant protein intake was associated with a decrease in diastolic blood pressure of 0.57 mm Hg (P , 0.001). Further adjustment for nutritional factors weakened these associations, but the inverse associations of total protein intake with diastolic blood pressure and of animal protein intake with systolic blood pressure remained statistically significant. Conclusion: Total and animal protein intakes were inversely associated with blood pressure in Japanese adults.

show abstract

Section: Discussionsupporting

confidence: 67%

“…Compared with previous Japanese and Chinese studies (6,8,9), we had a large number of subjects and conducted a more through adjustment for confounding variables. including alcohol intake.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS)

Umesawa

Sato

Imano

et al. 2009

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…14,15 Moreover, the average amount of protein we found in our population is comparable with the values reported in another study using the Maroni formula to estimate the amount of protein intake in a Japanese community-based cohort. 23 Another limitation of this study is that the protein intake we measure is susceptible to fluctuations because it reflects protein intake of only a few days before the urine collection; therefore, we based our protein intake on the average of two 24-h urine collections. In addition, we performed a sensitivity analysis including only individuals with a small difference in protein intake between the first and the second screening rounds.…”

Section: Discussionmentioning

confidence: 99%

High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function

Halbesma¹,

Bakker²,

Jansen³

et al. 2009

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

The long-term effects of higher dietary protein intake on cardiovascular and renal outcomes in the general population are not clear. We analyzed data from 8461 individuals who did not have renal disease and participated in two or three subsequent screenings (6.4-yr follow-up) in a prospective, communitybased cohort study (Prevention of Renal and Vascular ENd-stage Disease [PREVEND]). We calculated daily protein intake from 24-h urinary urea excretion (Maroni formula) and used Cox proportional hazard models to analyze the associations between protein intake, cardiovascular events, and mortality. We used mixed-effects models to investigate the association between protein intake and change in renal function over time. The mean Ϯ SD daily protein intake was 1.20 Ϯ 0.27 g/kg. Protein intake was significantly associated with cardiovascular events during follow-up. The associations seemed U-shaped; compared with intermediate protein intake, individuals with either higher or lower protein intake had higher event rates. All-cause mortality and noncardiovascular mortality also were significantly associated with protein intake; individuals with low protein intake had the highest event rates. We found no association between baseline protein intake and rate of renal function decline during follow-up. In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events.

show abstract

“…1 This inverse association is also found in more recent studies. [2][3][4] However, results have been mixed when animal and plant proteins were examined separately. Cross-sectional studies conducted in rural Japanese 5,6 and Chinese 7,8 populations only found an inverse relationship between animal protein and BP, based on ratios of urinary excretions of sulphate and other animal protein-related amino acids.…”

Section: Introductionmentioning

confidence: 99%

The relationship between dietary protein intake and blood pressure: results from the PREMIER study

Wang

Yancy

et al. 2008

J Hum Hypertens

View full text Add to dashboard Cite

Observational and clinical studies suggest that high protein intake, particularly protein from plant sources, might reduce blood pressure (BP). To examine the association of dietary protein with BP, we analysed data from PREMIER, an 18-month clinical trial (n ¼ 810) that examined the effects of two multi-component lifestyle modifications on BP. We examined the association of protein intake with BP, and in particular the independent relationship of plant and animal protein with BP. Multivariable linear regression analyses were performed with both cross-sectional and longitudinal data. Dietary plant protein was inversely associated with both systolic and diastolic BP in cross-sectional analyses at the 6-month follow-up (P ¼ 0.0045 and 0.0096, respectively). Fruit and vegetable intake was also inversely associated with both systolic and diastolic BP cross-sectionally at 6 months (P ¼ 0.0003 and 0.0157, respectively). In longitudinal analyses, a high intake of plant protein at 6 months was marginally associated with a reduction of both systolic and diastolic BP from baseline to 6 months only (P ¼ 0.0797 and 0.0866, respectively), independent of change in body weight and waist circumference. Furthermore, increased intake of plant protein, and fruits and vegetables was significantly associated with a lower risk of hypertension at 6 but not at 18 months. Results of this study indicate that plant protein had a beneficial effect on BP and was associated with a lower risk of hypertension at 6 months. Our data, in conjunction with other research, suggest that an increased intake of plant protein may be useful as a means to prevent and treat hypertension.

show abstract

Estimated Protein Intake and Blood Pressure in a Screened Cohort in Okinawa, Japan

Cited by 15 publications

References 22 publications

Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS)

Relations between protein intake and blood pressure in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS)

High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function

The relationship between dietary protein intake and blood pressure: results from the PREMIER study

Contact Info

Product

Resources

About