The current role of amphotericin B lipid complex in managing systemic fungal infections

Chu, Patrick; Sadullah, Shalal

doi:10.1185/03007990903379077

Cited by 16 publications

(16 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ergosterol is an important component of fungal membranes and serves the same function as cholesterol in animal cells. When ergosterol content decreases in fungal plasma membranes, AmB-binding sites might decrease, leading to AmB resistance [42], [43]. If this is indeed the mechanism for AmB resistance after PDR5 deletion, our results imply that Pdr5p is involved in ergosterol homeostasis.…”

Section: Discussionmentioning

confidence: 74%

Antagonistic Changes in Sensitivity to Antifungal Drugs by Mutations of an Important ABC Transporter Gene in a Fungal Pathogen

et al. 2010

View full text Add to dashboard Cite

Fungal pathogens can be lethal, especially among immunocompromised populations, such as patients with AIDS and recipients of tissue transplantation or chemotherapy. Prolonged usage of antifungal reagents can lead to drug resistance and treatment failure. Understanding mechanisms that underlie drug resistance by pathogenic microorganisms is thus vital for dealing with this emerging issue. In this study, we show that dramatic sequence changes in PDR5, an ABC (ATP-binding cassette) efflux transporter protein gene in an opportunistic fungal pathogen, caused the organism to become hypersensitive to azole, a widely used antifungal drug. Surprisingly, the same mutations conferred growth advantages to the organism on polyenes, which are also commonly used antimycotics. Our results indicate that Pdr5p might be important for ergosterol homeostasis. The observed remarkable sequence divergence in the PDR5 gene in yeast strain YJM789 may represent an interesting case of adaptive loss of gene function with significant clinical implications.

show abstract

Section: Discussionmentioning

confidence: 74%

Antagonistic Changes in Sensitivity to Antifungal Drugs by Mutations of an Important ABC Transporter Gene in a Fungal Pathogen

et al. 2010

View full text Add to dashboard Cite

show abstract

“…They have been used to deliver biomolecules that are difficult to administer, either because of hydrophobicity (e.g., amphotericin B) or because of rapid degradation in vivo (oligonucleotides) 107. Encapsulation in liposomes can also mitigate drug toxicity 108, 109. Numerous functionalities can be built into liposomes by tailoring membrane chemistry or excipients; examples include prolonged circulating times (PEG ligands on the membrane), cell‐specific targeting (antibody ligands on the membrane), functionality to encourage endocytosis (proteins on the membrane), magnetic field guidance (superparamagnetic nanoparticles in the interior), or imaging (magnetically or optically active nanoparticles in the interior).…”

Section: Near‐ir Triggeringmentioning

confidence: 99%

Remotely Triggerable Drug Delivery Systems

2010

View full text Add to dashboard Cite

Triggerable drug delivery systems enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity. Recently, a number of new materials have been developed that exhibit sensitivity to visible light, near-infrared (NIR) light, ultrasound, or magnetic fields. This responsiveness can be triggered remotely to provide flexible control of dose magnitude and timing. Here we review triggerable materials that range in scale from nano to macro, and are activated by a range of stimuli.

show abstract

“…The development of lipid-based preparation of amphotericin B agents such as abelcet and and liposomal preparation of amphotericin B agents (AmBisome) have shown broad spectrum activity of amphotericin B while reducing adverse events. 31 These nanoformulations have been found to be superior in terms of efficacy and safety than their conventional counterparts. Smart drug delivery systems are being envisioned that will have the capability to detect and treat an infection, nutrient deficiency, or other health problems even before symptoms are evident.…”

Section: Drug Deliverymentioning

confidence: 99%

Nanotechnology developments: opportunities for animal health and production

2012

View full text Add to dashboard Cite

Nanotechnology has opened up new vistas for applications in molecular biology, biotechnology and almost all the disciplines of veterinary and animal sciences. Excellence in animal health and production can be achieved by translation of this newer technology to create effective services and products for animals. The ability to manufacture and manipulate matter on the nanoscale has offered opportunities for application in diverse areas of animal sciences. Nanosensors, nanovaccines, adjuvants, gene delivery and smart drug delivery methods have the potential to revolutionize animal health and production. There can be numerous applications of the nanomaterials for disease diagnosis, treatment, drug delivery, animal nutrition, animal breeding, reproduction, tissue engineering and value addition to animal products. This paper reviews the recent developments in nanotechnology research and opportunities for application in animal sciences.

show abstract

The current role of amphotericin B lipid complex in managing systemic fungal infections

Cited by 16 publications

References 58 publications

Antagonistic Changes in Sensitivity to Antifungal Drugs by Mutations of an Important ABC Transporter Gene in a Fungal Pathogen

Antagonistic Changes in Sensitivity to Antifungal Drugs by Mutations of an Important ABC Transporter Gene in a Fungal Pathogen

Remotely Triggerable Drug Delivery Systems

Nanotechnology developments: opportunities for animal health and production

Contact Info

Product

Resources

About