The current outlook of human papillomavirus and its association with digestive tract cancer

Urrego, Isabel Cristina Almonacid; Urrego, Carmen Cecilia Almonacid; Arango, Sonia Marcela Rosas; Rojas, Edith del Carmen Hernández; Devia, Johanna Lizeth González

doi:10.22335/rlct.v13i1.1292

Cited by 4 publications

(2 citation statements)

References 76 publications

(87 reference statements)

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“…With increasingly predisposing factors, it was found that HPV might play an oncogenic role in these pathologies . Different types of HPV have large different association with epithelial tumor, and genotype distribution is related with the degree of differentiation of EC . In studies published, HPV6, 11, 16, 18, 24, 25, 26 31, 32, 33, 35, 39,42, 43, 45, 51, 52, 56, 58, 59, 66, 70, and 82 had been detected in EC tissue samples. ,− These studies were very consistent in suggesting the link between esophageal cancer and HPV infection, and literature information was summarized in Table .…”

Section: Discussionmentioning

confidence: 85%

Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line

Zhang

Pan

et al. 2021

Chem. Res. Toxicol.

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The relationship between human papillomavirus (HPV) and esophageal cancer (EC) has been controversial, which may be caused by the difference in geographic regions of sample origin. Thus, we conducted a case-control study to find that HPV increased the risk of esophageal cancer, and the HPV18 detection rate is the highest (24.2%) among patients with EC, suggesting that HPV18 could be the most risk subtype of HPV infected. We then identified high-risk HPV18 and N-methyl-N′-nitro-N-nitroso-guanidine (MNNG) to establish a model on the viral etiology cooperating with environmental carcinogens. Het-1A cells containing HPV18 were continuously exposed to MNNG or not; then the morphological phenotype and function assays were performed in 25th passage cells. MNNG promoted the proliferation and invasion abilities and inhibited apoptosis both in Het-1A-HPV18 and control group. However, the Het-1A-HPV18 had a stronger change in phenotypic features and formed more transformed foci in soft agar. Further, Western blot found p53 and p21 were down-regulated, and expression of c-Myc, MMP-2, and MMP-9 and Bcl-2/Bax ratio were up-regulated. Our results revealed that MNNG was easier to induce malignant transformation of Het-1A cells transfected with HPV18. It is good evidence for the close relationship between HPV and the etiology of EC, providing foundation for further study in molecular mechanism and specific intervention targets.

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Section: Discussionmentioning

confidence: 85%

Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line

Zhang

Pan

et al. 2021

Chem. Res. Toxicol.

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“…[ 5 ] Moreover, it is associated with colon, cervix, rectum, anus, vulva and oropharynx cancers. [ 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

Using theory of reasoned action to reduce high-risk sexual behaviors among patients with HPV: A randomized controlled trial

Zare

Pourgholamamiji

Shahsavari

et al. 2023

J Edu Health Promot

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BACKGROUND: Sexually transmitted diseases are a major health problem in all countries. Human papillomavirus (HPV) infection is the most common viral sexually transmitted disease in both genders. High-risk sexual behaviors (HRSBs) are among the major risk factors for HPV infection. Lack of knowledge can contribute to HRSBs and hence, education can potentially reduce HRSB risk. This is a study using theory of reasoned action to reduce the high-risk sexual behaviors among patients with HPV. MATERIALS AND METHODS: This study was a two-grouped, randomized, controlled trial. The educational program was developed based on the results of a survey into the most important components of the theory of reasoned action contributing to HRSBs among 100 patients recruited from Razi hospital, Tehran, Iran. Then, 110 patients from the same hospital were consecutively recruited and randomly allocated to a control ( n = 55) and an intervention ( n = 55) group. Then, each participant in the intervention group was provided with the developed educational program. Their counterparts in the control group solely received routine care services. Three months after the first educational session, HRSBs were reassessed in both groups. Data were analyzed via the SPSS software (v. 21.0). RESULTS: After the intervention, the mean score of HRSBs significantly decreased in the intervention group ( P < 0.001) but did not significantly change in the control group ( P = 0.70). The post-test mean score of HRSBs in the intervention group was significantly less than the control group ( P = 0.015). CONCLUSION: Education based on the theory of reasoned action is effective in significantly reducing HRSBs. Nurses can develop and use educational interventions based on this theory to reduce HRSBs and HPV infection.

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Acuerdos Bilaterales De Comercio y el Mercado de Servicios en Colombia. Década de 1990. ( Bilateral Trade Agreements and Services Sector in Colombia. 1990´s )

Pérez-Toro

2021

SSRN Journal

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The current outlook of human papillomavirus and its association with digestive tract cancer

Cited by 4 publications

References 76 publications

Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line

Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line

Using theory of reasoned action to reduce high-risk sexual behaviors among patients with HPV: A randomized controlled trial

Acuerdos Bilaterales De Comercio y el Mercado de Servicios en Colombia. Década de 1990. ( Bilateral Trade Agreements and Services Sector in Colombia. 1990´s )

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