The Current Landscape of Clinical Studies Focusing on Thyroid Cancer: A Comprehensive Analysis of Study Characteristics and Their Publication Status

Liu, Yihao; Li, Bin; Zheng, Qiuyi; Xu, Jia; Li, Jie; Lai, Fenghua; Lin, Bo; Peng, Sui; Lv, Weiming; Xiao, Hang

doi:10.3389/fendo.2020.575799

Cited by 3 publications

(10 citation statements)

References 29 publications

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“… 39 To increase the transparency of OSCC research execution and reporting, the rules for clinical trial registries need to be standardized. 9 …”

Section: Discussionmentioning

confidence: 99%

“…Although there have been some studies summarizing the characteristics of cancer clinical trials, 9 , 12 there is currently no formal or latest OSCC clinical trial evaluation. At present, doctors still lack a thorough understanding of OSCC clinical research.…”

Section: Introductionmentioning

confidence: 99%

“…10 In 2004, the International Committee of Medical Journal Editors (ICMJE) advocated that clinical trials should be recorded in a public registry before recruiting patients to ensure the transparency of clinical research. 9,11 The website is currently the world's largest clinical trial registration website, including almost all interventional human trials conducted in the United States as well as international studies from 185 countries. 10 Although there have been some studies summarizing the characteristics of cancer clinical trials, 9,12 there is currently no formal or latest OSCC clinical trial evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…9,11 The website is currently the world's largest clinical trial registration website, including almost all interventional human trials conducted in the United States as well as international studies from 185 countries. 10 Although there have been some studies summarizing the characteristics of cancer clinical trials, 9,12 there is currently no formal or latest OSCC clinical trial evaluation. At present, doctors still lack a thorough understanding of OSCC clinical research.…”

Section: Introductionmentioning

confidence: 99%

“…5 Clinical trials have been the foundation of evidence-based medicine and the driving force in the development of medicine. 9 The U.S. Food and Drug Administration Modernization Act (FDAMA) created ClinicalTrials.gov in 1997. FDAMA required the U.S. Department of Health and Human Services (HHS), through the National Institutes of Health (NIH), to establish a registry of clinical trials to provide the public with easy access to clinical trial information.…”

Section: Introductionmentioning

confidence: 99%

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The Current Landscape of Oral Squamous Cell Carcinoma: A Comprehensive Analysis from ClinicalTrials.gov

Zou

Wen

et al. 2022

Cancer Control

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Objective A better understanding of the current characteristics of clinical trials in oral squamous cell carcinoma (OSCC) is important to improve trial design and identify neglected areas of research. The objective is to summarize the current characteristics and publication status of OSCC trials registered on ClinicalTrials.gov. Methods The ClinicalTrials.gov database was searched on November 9, 2020, for trials containing the term “oral squamous cell carcinoma”. We assessed the characteristics of the included trials and searched the publication status of the primary completed trials by using PubMed and Google Scholar. Results Our search identified 325 studies for analysis, including 279 interventional (85.8%) and 46 observational (14.2%) studies. Interventional studies were mostly single-group (50.9%), single-center (57.0%), non-randomized (59.1%), open-label (81.4%), and early-phase (70.6%) trials. The vast majority of the studies (82.8%) focused on the treatment of OSCC. Chemotherapy (36.8%) was the most common treatment, followed by targeted therapy (15.2%) and immunotherapy (15.2%). Furthermore, 58.9% of the primary completed interventional studies were published by January 8, 2021, and the median time to publication was 48.0 months. Studies registered before this study began (HR = 1.69, 95% CI = 1.02–2.80, P = .040) and in phases 1/2 or 2 (HR = 2.10, 95% CI = 1.09–4.06, P = .026) were associated with an improved likelihood of publication. Conclusions OSCC clinical trials usually have small sample size and are open-label and non-randomized studies. Advanced OSCC and immunotherapy-oriented therapy are becoming the focus of current trials. Researchers should perform standardized registration and publish their results in a timely manner.

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“… 39 To increase the transparency of OSCC research execution and reporting, the rules for clinical trial registries need to be standardized. 9 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Current Landscape of Oral Squamous Cell Carcinoma: A Comprehensive Analysis from ClinicalTrials.gov

Zou

Wen

et al. 2022

Cancer Control

Self Cite

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A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

Ravin

Suresh

et al. 2022

World j. otorhinolaryngol.-head neck surg.

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Characteristics of Out-of-Hospital Cardiac Arrest Trials Registered in ClinicalTrials.gov

D’Andria Ursoleo,

Bugo,

Losiggio

et al. 2024

JCM

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Background/Objective: Out-of-hospital cardiac arrest (OHCA) poses a substantial public health concern. A collective evaluation of clinical trials is crucial for understanding systemic trends and progress within a specific research area of interest, ultimately shaping future directions. We performed a comprehensive analysis of the characteristics of trials in the adult OHCA population registered on ClinicalTrials.gov. Methods: Aided by medical subject headings (MeSH), we systematically searched the ClinicalTrials.gov database. Trends over time were assessed with the Cochran–Mantel–Haenszel test. The association between publication year and annual number was assessed with the Pearson correlation coefficient. Results: Out of 152 trials spanning the 2003–2023 period, 29.6% were observational and 70.4% were interventional. Compared with the observational trials, interventional trials were more often randomized (RCT) and achieved full publication status in 84% of cases (p = 0.03). The primary focus of interventional trials was “procedures” (43%), “devices” (23%), and “drugs” (21%). Observational studies focused on “biomarkers” (16%) and “diagnostic test” (13%) (p < 0.001). A decrement in the number of interventional trials with a sample size ≥100 patients across three temporal study points was observed. Nevertheless, published studies predominantly had a sample size ≥100 patients (76%), in contrast to unpublished trials (p ≤ 0.001). An increase in the number of interventional studies funded by the “academic/university” sector was also recorded. Conclusions: Clinical trials on OHCA primarily involved interventions aimed at treatment and were more often randomized, single-center, with small (<100) sample sizes, and funded by the “academic/university” sector.

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The Current Landscape of Clinical Studies Focusing on Thyroid Cancer: A Comprehensive Analysis of Study Characteristics and Their Publication Status

Cited by 3 publications

References 29 publications

The Current Landscape of Oral Squamous Cell Carcinoma: A Comprehensive Analysis from ClinicalTrials.gov

The Current Landscape of Oral Squamous Cell Carcinoma: A Comprehensive Analysis from ClinicalTrials.gov

A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

Characteristics of Out-of-Hospital Cardiac Arrest Trials Registered in ClinicalTrials.gov

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