A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

Xu, Katherine; Ravin, Emma De; Suresh, Neeraj; Brody, Robert M.; Rajasekaran, Karthik

doi:10.1002/wjo2.80

World j. otorhinolaryngol.-head neck surg.

2022

DOI: 10.1002/wjo2.80

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A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

Katherine Xu

Emma De Ravin

Neeraj Suresh

et al.

Abstract: Objective: Although standard of care for primary nasopharyngeal carcinoma (NPC) is chemoradiotherapy, there remains no consensus on management of recurrent or metastatic disease. We characterized recent clinical trials on NPC to assess trends in NPC treatment and establish promising areas for future research.

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2024

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Racial Disparities in Nasopharyngeal Carcinoma Characteristics and Survival

Yu,

Xu,

Chen

et al. 2024

Ear Nose Throat J

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Objective: To investigate and compare the distribution of histological subtypes, stage at presentation, and survival outcomes among Chinese American, Non-Hispanic White, and African American patients with nasopharyngeal carcinoma (NPC). Materials and methods: We identified Chinese American, Non-Hispanic White, and African American patients with NPC who were diagnosed between 2010 and 2017. Statistical analyses were conducted using the chi-square test, propensity score matching, Kaplan-Meier analysis, and multivariate Cox proportional hazards models. Results: A total of 1646 eligible patients with NPC were included. Non-Hispanic White accounted for 1049 (63.7%), African Americans for 265 (16.1%), and Chinese Americans for 332 (20.2%), and their median age at diagnosis was 59, 55, and 53 years, respectively ( P < .001). Chinese Americans most frequently harbored undifferentiated non-keratinizing squamous cell carcinoma subtype (n = 134, 40.4%) than Non-Hispanic White (n = 164, 15.6%) or African American patients (n = 44, 16.7%) ( P < .001). Histological subtype distribution was similar between Non-Hispanic White and African American patients ( P = .338). African American patients had the highest rate of stage III to IV disease (n = 206, 77.7%) compared to Non-Hispanic White (n = 704, 67.1%) and Chinese American patients (n = 210, 63.2%) ( P = .009). No significant difference in stage distribution was observed between Chinese American and Non-Hispanic White patients ( P = .494). Non-Hispanic White patients [hazard ratio (HR) 1.344, 95% confidence interval (CI) 1.007-1.479, P = .045] and African American patients (HR 2.314, 95% CI 1.405-3.813, P < .001) had significantly worse overall survival compared to Chinese American patients. However, race was not associated with NPC-specific survival in the multivariate analysis. Similar results were found after propensity score matching. Conclusions: Race influences the distribution of histological subtypes, stage at presentation, and survival outcomes in NPC.

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Racial Disparities in Nasopharyngeal Carcinoma Characteristics and Survival

Yu,

Xu,

Chen

et al. 2024

Ear Nose Throat J

View full text Add to dashboard Cite

show abstract

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A comprehensive review and characterization of nasopharyngeal carcinoma clinical trials

Cited by 1 publication

References 20 publications

Racial Disparities in Nasopharyngeal Carcinoma Characteristics and Survival

Racial Disparities in Nasopharyngeal Carcinoma Characteristics and Survival

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