The Curative Treatment by Radiotherapy Alone of Stage I Non-Small Cell Carcinoma of the Lung

Gauden, Stan; Ramsay, Jonathan; Tripcony, Lee

doi:10.1378/chest.108.5.1278

Cited by 139 publications

(66 citation statements)

References 17 publications

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“…First, survival time was in most cases inferior compared to prospective or retrospective investigations in the literature [10,16,22,23,26]. Second, we found a strikingly high number of patients who were treated with doses in the range of 50 to < 60 Gy.…”

Section: Discussionmentioning

confidence: 54%

Survival of Patients in Clinical Stages I–IIIb of Non-Small-Cell Lung Cancer Treated with Radiation Therapy Alone

et al. 2004

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Section: Discussionmentioning

confidence: 54%

Survival of Patients in Clinical Stages I–IIIb of Non-Small-Cell Lung Cancer Treated with Radiation Therapy Alone

et al. 2004

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“…Although some studies suggested better survival rates with increasing doses of radiation (10,14,20), others did not (7,11). Some studies showed that histologic type (22) and initial response to radiation (12) were associated with improved patient survival. None of the studies however, included an untreated control group.…”

Section: Discussionmentioning

confidence: 99%

“…Several retrospective analyses have reported the outcomes of patients treated with RT alone but did not include a control group (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). These studies showed that the prognosis of these patients is poor, with a 20% (range 13-39%) 5-year lung cancer-specific survival rate.…”

mentioning

confidence: 99%

Effectiveness of Radiation Therapy for Elderly Patients with Unresected Stage I and II Non–Small Cell Lung Cancer

Wisnivesky

Halm

Bonomi

et al. 2010

Am J Respir Crit Care Med

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Rationale: Radiotherapy (RT) is considered the standard treatment for patients with stage I or II non-small lung cancer who are not surgical candidates because of comorbities or preferences against surgery. Objectives: To compare the outcomes of patients treated with RT alone with those who were untreated to assess the effect of RT on survival. Methods: Using the Surveillance, Epidemiology and End Results (SEER) registry linked to Medicare files, we identified 6,065 unresected patients with histologically confirmed stage I and stage II non-small cell lung cancer, diagnosed between 1992 and 2002. We used propensity score methods and instrumental variable analysis to control for the possible effects of known as well as unmeasured confounders. Measurements and Main Results: Overall, 59% of patients received RT. The overall and lung cancer-specific survival of unresected patients treated with RT was significantly better compared with the untreated cases (P , 0.0001 for both comparisons). RT was associated with a 6-month improvement in median overall survival. Propensity score analyses showed that RT was associated with improved overall (hazard ratio, 0.74; 95% confidence interval, 0.70-0.78) and lung cancer-specific survival (hazard ratio, 0.73; 95% confidence interval, 0.69-0.78). Instrumental variable analysis also indicated improved outcomes among patients treated with RT. Conclusions: RT improves survival of elderly patients with unresected stage I or II lung cancer. These results should be confirmed in prospective trials.

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“…Many studies have demonstrated the prognostic factors of radiotherapy for early stages, including radiation dose [14], tumor size [15], nodal status [16]. There is only one study that shows the differences in survival based on the histological subtype, however, squamous cell carcinomas are known to have better results [17].…”

Section: Discussionmentioning

confidence: 99%

Clinical patterns and treatment outcome of elderly patients in clinical stage IB/II non‐small cell lung cancer

Okamoto¹,

Maruyama²,

Fukushima³

et al. 2004

Journal of Surgical Oncology

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The Curative Treatment by Radiotherapy Alone of Stage I Non-Small Cell Carcinoma of the Lung

Cited by 139 publications

References 17 publications

Survival of Patients in Clinical Stages I–IIIb of Non-Small-Cell Lung Cancer Treated with Radiation Therapy Alone

Survival of Patients in Clinical Stages I–IIIb of Non-Small-Cell Lung Cancer Treated with Radiation Therapy Alone

Effectiveness of Radiation Therapy for Elderly Patients with Unresected Stage I and II Non–Small Cell Lung Cancer

Clinical patterns and treatment outcome of elderly patients in clinical stage IB/II non‐small cell lung cancer

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