The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men

Liu, Ming; Shi, Xiaohong; Yang, Fan; Wang, Jian‐Ye; Xu, Yong; Dong, Wei; Yang, Kuo; Zhang, Yaoguang; Wang, Xin; Liang, Siying; Chen, Xin; Sun, Liang; Zhu, Xiaoquan; Zhao, Chengxiao; Zhu, Ling; Tang, Lei; Zheng, Chengchao; Yang, Ze

doi:10.3390/ijerph13020162

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…reported the association of six variants with PCa and their cumulative effect (32). This relationship suggested that men who carried any combination of 1, 2, or >3 risky genotypes had a gradually increased PCa risk.…”

Section: Discussionmentioning

confidence: 97%

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

Beyene

Daremipouran

Apprey

et al. 2020

Cancer Genomics Proteomics

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Background: Prostate cancer (PCa) is a multifactorial disease involving complex interactions between genetic and physiological/environmental factors. Vitamin D receptor (VDR) plays a role in numerous cellular pathways and it has been suggested that VDR genetic variants influence individual susceptibility to PCa. Materials and Methods: Logistic regression analysis was used to assess the association of six VDR single nucleotide polymorphisms (SNPs) and factors such as tanning potential and UV sunlight exposure with PCa risk. Results: Marginal significant interactions were found, with a 2-fold increase risk of PCa between SNP 1 (c.278-69G>A) and sunlight UV exposure [odds ratio (OR)=2.02, 95% confidence intervaI (CI)=1.036-4.36; p=0.05]; and a 4-fold increase risk of PCa between SNP 4 (c.907+75C>T) and tanning potential (OR=4.40, 95% CI=0.89-29.12; p=0.0591). In contrast, SNP 5 (rs731236, TaqI) and tanning potential interaction had a protective effect by reducing the risk of PCa by 55% (β=−0.804; OR=0.448, 95% CI=0.197-9.42; p=0.0427). SNPs 2 (rs61614328) and 6 (rs533037428) did not show any association with PCa even in the presence of UV sunlight exposure. Conclusion: The protective effect of SNP 4 from PCa is lost and modified by tanning potential in African Americans. This finding needs to be verified by larger studies in different ethnic populations. Prostate cancer (PCa) has high incidence as well as high mortality, which makes it an important worldwide health issue (1, 2). Furthermore, PCa etiology is complex, involving many risk factors such as age, vitamin D status, ethnic origin, and family history of PCa (3, 4). Epidemiological studies suggest that PCa risk may at least partly be determined by interactions between the environment and genetic predisposition (5-7). PCa rates are higher in African American men compared to other ethnic groups in the United States (4, 5, 8). Additionally, this group of men are more likely to be diagnosed at a later stage of disease development. PCa risk has been inversely associated with sun exposure. In most individuals, about 90% of circulating levels of 25hydroxyvitamin D are derived from casual sun exposure (9). In the United States, high residential sun exposure has been associated with lower mortality rates and reduced risk for PCa (10, 11). A case-control study by Luscombe et al. found a 3fold increased risk with low lifetime sun exposure (12). Vitamin D is an important candidate implicated in PCa risk and its deficiency has been hypothesized to be a risk factor for PCa (13, 14). Reduced vitamin D levels correlate with established risk factors such as increasing age, African American ethnicity, and residence in northern latitudes (15). Cordera et al. also used diagnostic serum samples from blood to show that the risk of PCa decreased with higher levels of 1,25-dihydroxyvitamin D (6). The physiological and environmental factors that modify the supply of cutaneous vitamin D are levels of UV exposure, skin pigmentation, and polymorphism in the vitamin D receptor (VDR) gene ...

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Section: Discussionmentioning

confidence: 97%

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

Beyene

Daremipouran

Apprey

et al. 2020

Cancer Genomics Proteomics

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“…Furthermore, the interaction between the increased risk of prostate cancer and SNP variation of rs 1447295 was observed by several studies. 17,21 In other disease settings, some studies also found that the T allele of 8q24 rs10090154C>T was involved in the development of colorectal organ tumorigenesis. 30,31 They found that the T allele remained the important predictor in the development of tumorigenesis in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we included a total of 16 papers in our meta-analysis. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] We outline the flowchart of included papers in Figure 1, and the baseline characteristics are provided in Table 1.…”

Section: Eligible Studiesmentioning

confidence: 99%

The 8q24 Rs10090154c>T Gene Variant and Its Association with the Risk of Prostate Cancer: A Systematic Review and Meta-analysis

Prasetyawan¹,

Salsabila²,

Ilmawan³

et al. 2021

Turkiye Klinikleri J Med Sci

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Genetic variation at chromosome 8q24 is considered as the potential biomarker for prostate cancer. We aimed to assess the relation between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer. Material and Methods: A meta-analysis was carried out in January to June 2020 by collecting relevant studies through online databases. The correlation and estimated effect between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer were analyzed using a Z test. Results: A total of 16 relevant studies were selected (16,842 cases and 18,258 controls). In overall, T allele and CT genotype of 8q24 rs10090154C>T gene polymorphism increased the risk of prostate cancer (OR95%CI=1.238 [1.14-1.34], p<0.001; OR95%CI=1.238 [1.14-1.35], p<0.001) while CC genotype and C allele had protective effect (OR95%CI=0.800 [0.74-0.87], p<0.001; OR95%CI=0.808 [0.75-0.88], p<0.001). Subgroup analysis of Caucasian population revealed that T allele of 8q24 rs10090154C>T was associated with increased risk of prostate cancer (OR95%CI=1.285 [1.07-1.54], p<0.001), while C allele had protective effect (OR95%CI=0.778 [0.65-0.93], p=0.007). In Asian population, CT genotype of 8q24 rs10090154C>T was correlated with increased risk of prostate cancer (OR95%CI=1.302 [1.17-1.45], p<0.001), while CC genotype had protective effect (OR95%CI=0.770 [0.64-0.92], p=0.005). Conclusion: Our meta-analysis confirmed that 8q24 RS10090154C>T gene polymorphism had strong association with the risk of prostate cancer.

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“…Although the incidence of prostate cancer in China is lower than that in western developed countries, the number of patients with prostate cancer is huge because of the large population base and increasing age 14. Radical prostatectomy is commonly used in the treatment of early prostate cancer, and patients usually have a good prognosis.…”

Section: Discussionmentioning

confidence: 99%

Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer

Zhao¹,

Fu²

2019

Pak J Med Sci

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Objective: To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods: Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our hospital from November 2014 to August 2015 were selected using random number table method. They were divided into intensity-modulated radiotherapy combined with endocrinotherapy group (observation group) and conventional radiotherapy combined with endocrinotherapy group (control group), 52 each. The serum levels of prostate specific antigen (PSA) and free prostate antigen (f PSA) were measured three months after treatment. The short-term efficacy and toxic and side effects of the patients were observed, and the survival rate was recorded through three-year follow up. Results: The clinical effective rate of the observation group was 92.68%, and that of the control group was 70.73%; there was a significant difference between the two groups (P<0.05). The serum PSA and f PSA levels of the two groups were similar before treatment, but there was no significant difference (P>0.05). The serum PSA and f PSA levels after treatment were significantly lower than before treatment. The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The one-year and three-year survival rates of the two groups were significantly different (90.0 vs. 80.0%, 60.0 vs. 43.3%, P>0.05). Conclusion: Intensity modulated radiotherapy combined with endocrinotherapy was safe and well tolerated in the treatment of middle and advanced prostate cancer. It can improve the short-term efficacy and effectively reduce the serum oncological index concentration of patients. It can be promoted in clinics. doi: https://doi.org/10.12669/pjms.35.5.591 How to cite this:Zhang S, Zhao S, Fu X. Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.591 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men

Cited by 8 publications

References 46 publications

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential

The 8q24 Rs10090154c>T Gene Variant and Its Association with the Risk of Prostate Cancer: A Systematic Review and Meta-analysis

Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer

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