METHODS
Study designThis study aimed to determine the association between diabetes and hypertension as the risk factors for AKI in COVID-19 patients. Therefore, we calculated the combined odds ratio (OR) and a 95% confidence interval (95% CI) using a random or fixed-effect model. To ensure the quality of our study, we created a meta-analysis using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist 8 .
Genetic variation at chromosome 8q24 is considered as the potential biomarker for prostate cancer. We aimed to assess the relation between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer. Material and Methods: A meta-analysis was carried out in January to June 2020 by collecting relevant studies through online databases. The correlation and estimated effect between the gene variant of 8q24 rs10090154C>T and the risk of prostate cancer were analyzed using a Z test. Results: A total of 16 relevant studies were selected (16,842 cases and 18,258 controls). In overall, T allele and CT genotype of 8q24 rs10090154C>T gene polymorphism increased the risk of prostate cancer (OR95%CI=1.238 [1.14-1.34], p<0.001; OR95%CI=1.238 [1.14-1.35], p<0.001) while CC genotype and C allele had protective effect (OR95%CI=0.800 [0.74-0.87], p<0.001; OR95%CI=0.808 [0.75-0.88], p<0.001). Subgroup analysis of Caucasian population revealed that T allele of 8q24 rs10090154C>T was associated with increased risk of prostate cancer (OR95%CI=1.285 [1.07-1.54], p<0.001), while C allele had protective effect (OR95%CI=0.778 [0.65-0.93], p=0.007). In Asian population, CT genotype of 8q24 rs10090154C>T was correlated with increased risk of prostate cancer (OR95%CI=1.302 [1.17-1.45], p<0.001), while CC genotype had protective effect (OR95%CI=0.770 [0.64-0.92], p=0.005). Conclusion: Our meta-analysis confirmed that 8q24 RS10090154C>T gene polymorphism had strong association with the risk of prostate cancer.
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