In a comparative study of evil eye (mal de ojo), we demonstrate a methodology appropriate for the study of cultural transmission of beliefs. We studied four diverse populations with historical links to Spain: Puerto Ricans in Connecticut, Mexican Americans in south Texas, Mexicans in Guadalajara, and rural Guatemalans. Using agreement on ideas or themes about evil eye within and across sites, we identify specific ideas that may have persisted through time. The relevance of specific themes was estimated with a cultural consensus analysis. Mal de ojo was widely recognized in each community and higher community prevalence was associated with higher agreement on reported causes, symptoms, and treatments. Each community exhibited a distinct model for ojo, although models were highly similar between sites.