The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene

Evaluation of <i>Moringa oleifera</i> Leaf Extract on Alcohol-induced Hepatotoxicity

“…Increased lipid peroxidation under ethanol treated conditions of rats left without pre or post treatment was due to increased oxidative stress as a result of depletion of the antioxidant scavenger system which might have resulted in changes in the cellular metabolism of the liver 14 . The observed decreased in the level of serum vitamin C (an antioxidant) in alcohol treated group only could be as a result of increased utilization of this antioxidant in scavenging the free radicals generated or produced during acute alcohol induction 17 . Pretreatment of rats with the extract at the different doses administered resulted in significant increase in the levels of vitamin C. This indicates that the extract was able to raise the vitamin C levels of the pretreated animals, and increased the ability to combat produced free radicals.…”

In vitro protective effect of Schisandra chinensis extract against carbon tetrachlorideinduced hepatotoxicity in common carp (Cyprinus carpio)

“…The biochemical mechanism involved in the development of CCl 4 hepatotoxicity has long been investigated: it is now generally believed that the formation of reactive trichloromethyl radicals (CCl 3 ) from CCl 4 by CYP 450 is a crucial factor in the pathogenesis of CCl 4 hepatotoxicity (Ip and Ko, 1996). In the presence of oxygen, CCl 3 is quickly transformed into trichloromethyl peroxyl radical (CCl 3 O 2 ), CCl 3 O 2  binds covalently to cellular proteins or lipids, and initiates the lipid peroxidation in the cellular membrane (Levine and Reinhardt, 1983) resulting in the leakage of cellular enzymes (LDH, GPT and GOT) and finally cell apoptosis and necrosis (Manibusan et al, 2007).…”

The Effects of Butylated Hydroxyl Toluene on the Total Anti̇oxi̇dant Status/ Total Oxi̇dant Stress and Bi̇ochemi̇cal Parameters in Rats

“…[31] Devi et al [32] determined an increase in the serum protein level, and the www.wjpps.com In a study with different BHT doses, the serum ALT, AST and GGT activities were found to be increased, whereas the total protein and albumin levels were found to be decreased. This outcome was observed in a dose-dependent manner and was maximum in the 1000 mg/kg group.…”