The cross‐sectional associations between objectively measured sedentary time and cardiometabolic health markers in adults – a systematic review with meta‐analysis component

Abstract

Sedentary time is viewed as an independent risk factor for adverse cardiometabolic health (CMH). No systematic review and meta-analysis on the cross-sectional associations between objectively measured sedentary time and CMH markers has been conducted. PubMed, Scopus and Web of Science Core Collection were searched for papers that examined the cross-sectional association between objectively measured sedentary time and CMH markers in adults. Forty-six papers met the inclusion criteria. The included papers had a combined sample size of 70,576 and an age range of 18-87 years. To examine the effect of increased levels of sedentary time on CMH markers, data on effect sizes and moderators were extracted, where possible. By pooling the unadjusted data from the included papers, increased sedentary time was shown to have a significant detrimental association with fasting glucose (Δ = 0.12, 95% confidence interval [CI]: 0.02, 0.23), fasting insulin (Δ = 0.19, 95% CI: 0.06, 0.32), triglycerides (Δ = 0.25, 95% CI: 0.14, 0.37), high-density lipoprotein cholesterol (Δ = -0.20, 95% CI: -0.28, -0.13) and waist circumference (Δ = 0.25, 95% CI: 0.15, 0.35). How sedentary time was quantified and the device used to measure sedentary time significantly influence the size of the effect reported. Future interventions focused on both decreasing sedentary time and increasing physical activity may be the most effective strategy to improve CMH.

Sedentary behavior in everyday life relates negatively to mood: An ambulatory assessment study

“…Although this decision might have maximized the effects of interest, we cannot generalize our findings to other populations; thus, additional investigations are warranted. Third, Powell et al questioned the validity of detecting sedentariness by a single sensor systems. Thus, we applied a custom‐developed multisensor system with accelerometers at hip, chest, and thigh to enable precise detection of body posture.…”

Relationship Between Sitting Time, Physical Activity, and Metabolic Syndrome Among Adults Depending on Body Mass Index (BMI)

“…However, these associations turned out to be insignificant after corrections for fitness and moderate-to-vigorous PA. Analysis of cross-sectional studies conducted by Powell et al [ 64 ] showed, however, that increased sedentary time had a significant detrimental association with waist circumference, fasting glucose, triglycerides, and HDL cholesterol. However, a meta-analysis conducted by Wirth et al [ 28 ] in older people showed that waist circumference was positively associated with sedentary behavior in 7 cross-sectional studies and 1 prospective observational study, which is consistent with the results of our research.…”

Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

“…Considerable evidence suggests that sedentary time affects health outcomes regardless of physical activity4. Especially, many previous studies showed that cardiovascular disease and its risk factors are associated with sedentary time 3 , 15 – 17 ) . This study was conducted to determine the associations of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus in a large Japanese population according to age and sex.…”